CIALIS SUMMARY
CIALIS® (tadalafil), an oral treatment for erectile dysfunction, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
CIALIS is indicated for the treatment of erectile dysfunction.
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NEWS HIGHLIGHTSMedia Articles Related to Cialis (Tadalafil)
Specialists Available To Discuss Worldwide Epidemic Of Heart Disease Among South Asians
Source: Cardiovascular / Cardiology News From Medical News Today [2010.02.03]
Growing evidence shows that people of South Asian descent-regardless of where they live now-are at significantly higher risk of heart disease. As we approach American Heart Month, the team of physicians and researchers at the South Asian Heart Center at El Camino Hospital are available to discuss this epidemic, and what strategies are being used successfully to combat it...
Enrolments For The RACGP Specialist Pathway Open On 1 February! Australia
Source: Primary Care / General Practice News From Medical News Today [2010.01.29]
The Royal Australian College of General Practitioners (RACGP) is pleased to announce that from Monday, 1 February 2010 the college can formally take enrolments for the RACGP Specialist Pathway...
New Use for Active Ingredient of Cialis
Source: MedicineNet Pulmonary Hypertension Specialty [2009.06.01]
Title: New Use for Active Ingredient of Cialis
Category: Health News
Created: 6/1/2009
Last Editorial Review: 6/1/2009
Cancer Research UK Launches Groundbreaking Research Centre In Cambridge, UK
Source: Health News from Medical News Today [2010.02.04]
The launch of a centre puts Cambridge at the forefront of cancer research, bringing benefits to patients in the South East. The Cambridge Cancer Centre is a major new research collaboration which exists though a unique partnership between Cancer Research UK, Cambridge University, Cambridge University Hospitals NHS Foundation Trust and Cambridge University Health Partners. The Centre will be funded by Cancer Research UK to the tune of £2 million a year and is the latest in a specialist network of similar initiatives across the UK...
Tiny Constraints In Heart Blood Flow: A Better Sign Of Blood Vessel Narrowing And Early Coronary Artery Disease
Source: Cardiovascular / Cardiology News From Medical News Today [2010.02.04]
Cardiologists and heart imaging specialists at 15 medical centers in eight countries, and led by researchers at Johns Hopkins, have enrolled the first dozen patients in a year-long investigation to learn whether the subtle squeezing of blood flow through the inner layers of the heart is better than traditional SPECT nuclear imaging tests and other diagnostic radiology procedure...
Published Studies Related to Cialis (Tadalafil)
Randomized Placebo-Controlled Crossover Trial of Tadalafil in Raynaud's Phenomenon Secondary to Systemic Sclerosis. [2009.10]
OBJECTIVE: Raynaud's phenomenon (RP) is an important clinical feature of systemic sclerosis (SSc) for which consistently effective therapies are lacking. The study was designed to assess the safety, tolerability, and efficacy of tadalafil, a selective, long acting type V cyclic GMP phosphodiesterase (PDE-5) inhibitor, in this clinical syndrome... CONCLUSION: Tadalafil appears to be safe and well tolerated but lacks efficacy in comparison to placebo as a treatment for RP secondary to SSc.
[Chronic PDE-5 inhibition in patients with erectile dysfunction : New treatment approach using once daily Tadalafil.] [2009.09.09]
Erectile dysfunction (ED) is often associated with increased cardiovascular risk. There is increasing evidence suggesting that dysfunction of the vascular endothelium with reduced bioavailability of nitric oxide (NO) may be the pathogenetic link between ED and cardiovascular disease... Interestingly in a pilot study of on-demand versus chronic administration of Tadalafil for 4 weeks, only regular dosing improved several markers of endothelial function.
Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. [2009.08.15]
RATIONALE: Whether pulmonary hypertension at high altitude limits exercise capacity remains uncertain. OBJECTIVES: To gain further insight into the pathophysiology of hypoxia induced pulmonary hypertension and the resulting reduction in exercise capacity, we investigated if the reduction in hypoxic pulmonary vasoconstrictive response with corticosteroids or phosphodiesterase-5 inhibition improves exercise capacity... CONCLUSIONS: Corticosteroids, but not phosphodiesterase-5 inhibition, partially prevented the limitation of exercise capacity in subjects with intense hypoxic pulmonary vasoconstriction at high altitude.
Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily. [2009.07]
An efficacy study of tadalafil (5 mg once daily) for treating erectile dysfunction included sexual satisfaction and psychosocial outcome measures such as Treatment satisfaction (THX) domain of Sexual Life Quality Questionnaire, Self-Esteem And Relationship (SEAR) questionnaire, Sexual Encounter Profile questions 4 (SEP4; hardness satisfaction) and 5 (SEP5; overall satisfaction), intercourse satisfaction (IS) and overall satisfaction (OS) domains of International Index of Erectile Function (IIEF), and partner SEP question 3 (pSEP3)...
Impact on erectile function and sexual quality of life of couples: a double-blind, randomized, placebo-controlled trial of tadalafil taken once daily. [2009.05]
CONCLUSIONS: Tadalafil 5 mg once daily significantly improved EF and sexual quality of life for men with ED. In addition, the sexual quality of life of the female partners of the men treated with tadalafil was significantly improved.
Clinical Trials Related to Cialis (Tadalafil)
Study of Tadalafil for the Treatment of Diabetic Patients With Symptoms of Upset Stomach and Delayed Stomach Emptying [Completed]
The purposes of this study are to determine whether an experimental drug known as tadalafil
can reduce symptoms of dyspepsia (fullness after eating, inability to finish a regular meal,
bloating, discomfort or pain in the upper abdomen, belching after meals, nausea, vomiting) in
diabetic patients, and/or reduce the amount of time the stomach takes to empty the contents
of a standard meal. The safety of tadalafil given once daily for 8 weeks in this population
will also be studied.
Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia [Active, not recruiting]
This is a randomized, double-blind, placebo-controlled, parallel-design, multinational,
12-week study to compare the efficacy, dose response, and safety of tadalafil once a day
versus placebo in men with signs and symptoms of benign prostatic hyperplasia, including
lower urinary tract symptoms.
PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension [Completed]
Study the Safety and Effectiveness of Tadalafil in Men With Problems Getting or Maintaining an Erection When Taken Prior to Desiring an Erection [Completed]
Study to determine how safe and effective tadalafil is for Japanese men taking it when they
need to get and keep an erection.
A Study to Evaluate the Efficacy and Safety of 2.5mg and 5mg Tadalafil Given Once a Day to Men With Erectile Dysfunction [Completed]
This is a multicenter, randomized, double blind, placebo-controlled, parallel design study to
evaluate the efficacy and safety of 2. 5mg and 5mg tadalafil taken once daily in men with
erectile dysfunction.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 5 ratings/reviews, Cialis has an overall score of 8.20. The effectiveness score is 9.20 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Cialis review by 59 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | impotence |
| Dosage & duration: | | 20mg taken 5 days for the period of 5 days |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Cialis taken as prescribed. Had immediate postitive effect as promised, strong, long-lasting erection. Intercourse possible for long period of time- approx 2 days. Had no side-effects at all. Am very satisfied and recommend. |
| Side effects: | | No side effects at all. No headache, gastro-intestinal disturbances or other. |
| Comments: | | Took tadalafil 20 mg in the evening after meal. Had erection approx 30 min later. Erection lasted for 2 days- had never experienced such long-lasting erection. |
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| | Cialis review by 41 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Erectile dysfunction |
| Dosage & duration: | | 20mg taken 1pill a few hours before sexual activity for the period of still using it |
| Other conditions: | | unfit and overweight |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Increased confidence, more frequent sex, renewed intimacy with partner. |
| Side effects: | | Blocked sinus, headaches and backpain. Cialis was prescribed to be taken before sex. Because the drug can be effective for up to 36 hours taking another pill even 24 hours later increased the side effects substantially. |
| Comments: | | The treatment was to take Cialis before expected sexual activity. The timing wasn't essential due to the long lasting effect of the drug. |
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| | Cialis review by 53 year old male patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | ED |
| Dosage & duration: | | 20 mg taken as needed for the period of two weeks |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Long lasting erection |
| Side effects: | | achy joints similar to flu symptoms during the next couple of days after taking. Not bad, but definitely annoying. Aspirin helps relieve, but I did not like having to take a pill to counteract another pill. I do not have the same symptom with Viagra. |
| Comments: | | Taken as needed for ED. It is effective in as little as 30 minutes. Time depends if taken on empty stomach or after a meal. |
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Page last updated: 2010-02-04
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