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Chlorthalidone (Chlorthalidone) - Drug Interactions, Contraindications, Overdosage, etc

 
 



Drug/Laboratory Test Interactions

Chlorthalidone and related drugs may decrease serum PBI levels without signs of thyroid disturbance.

OVERDOSAGE

Symptoms of acute overdosage include nausea, weakness, dizziness, and disturbances of electrolyte balance. The oral LD50 of the drug in the mouse and the rat is more than 25,000 mg/kg body weight. The minimum lethal dose (MLD) in humans has not been established. There is no specific antidote, but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium, administered with caution.

CONTRAINDICATIONS

Anuria.

Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.

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