NEWS HIGHLIGHTSMedia Articles Related to Chlorphen Mal Pseudoeph (Chlorpheniramine / Pseudoephedrine)
Relief From Ragweed Allergy Symptoms Offered By Once-A-Day Pill
Source: Allergy News From Medical News Today [2013.05.10]
An international team of researchers, led by physician-scientists at Johns Hopkins, reports that a once-daily tablet containing a high dose of a key ragweed pollen protein effectively blocks the runny noses, sneezes, nasal congestion and itchy eyes experienced by ragweed allergy sufferers...
Children May Be Protected Against Developing Allergy If Parents Clean Pacifiers By Sucking Them
Source: Allergy News From Medical News Today [2013.05.10]
Swedish researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, report that a simple habit may give significant protection against allergy development, namely, the parental sucking on the baby's pacifier. Allergies are very common in industrialized countries...
Electricity May Be The Key To A Successful Vaccine Against Dust Mite Allergy
Source: Allergy News From Medical News Today [2013.05.09]
A new type of DNA vaccine technology could be enhanced with an electric charge during vaccination to help prevent dust mite allergies. The finding was published in Immunology Letters and details how a new type of DNA vaccine is effective in mice against dust mite allergies...
Chalk Dust Can Contain Milk Protein, Triggering Respiratory Symptoms In Children With Milk Allergy
Source: Respiratory / Asthma News From Medical News Today [2013.05.06]
Many of today's school teachers opt for dustless chalk to keep hands and classrooms clean. But according to a study published in the May issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), this choice in chalk may cause allergy and asthma symptoms in students that have a milk allergy...
Study: Suck Your Child's Pacifier to Cut Allergy Risk (CME/CE)
Source: MedPage Today Allergy & Immunology [2013.05.06]
(MedPage Today) -- Parents who suck on their child's pacifier to clean it may be inadvertently reducing that child's risk of developing allergies, researchers found.
Clinical Trials Related to Chlorphen Mal Pseudoeph (Chlorpheniramine / Pseudoephedrine)
Study of AHIST in Seasonal Allergic Rhinitis Patients [Not yet recruiting]
Objectives:
A) To gather pharmacodynamic measurements and assess blood levels of the active ingredients
in AHIST over the dosage interval period of 12 hours.
Hypothesis: Hysteresis curves plotting each active ingredient's blood levels over a 12-hour
dosage interval will substantiate S5 Symptom Diary scores (IE: evidentiary therapeutic
window data);
B) To report subjective scores by subjects rating the efficacy of a single dose AHIST in
relieving nasal congestion, rhinorrhea, nasal itching, sneezing, and post-nasal drip over a
12-hour dosage interval.
Hypothesis: Greater than 66% of subjects will document clinically significant relief over a
12-hour period from one dose of AHIST;
C) Report any side effects or adverse drug reactions and rate the severity of any incidence.
Hypothesis: Not more than one patient will have an adverse event significant enough to
warrant withdrawal; side effects will be mild with the most frequently reported side effect
occurring in less than 10% of patients—drowsiness.
Efficacy and Safety Assessment of an Anti-Cold Preparation in the Symptomatic Treatment of Common Cold and Flu-Like Syndrome [Recruiting]
Evaluation of Efficacy and Safety of Oral Solution Resfenol in Reducing Symptoms of Common Cold And Flu [Not yet recruiting]
This study aimed to evaluate the efficacy and safety of the oral solution of paracetamol,
chlorpheniramine maleate and phenylephrine hydrochloride in reducing symptoms of flu and the
common cold. There will be a randomized, double-blind, placebo-controlled trial. Will be
included 216 subjects, male or female, aged greater than 12 and less than or equal to 60
years, irrespective of color and / or race with symptoms of recent onset, for more than 6
hours and less than 48 hours length, characterizing Common Cold and / or Influenza.
After clinical evaluation and laboratory research subjects will be randomized to receive
active drug or placebo, 10 ml oral solution every 6 hours for 48 hours. The follow-up visits
will be held on 2 (24 hours after first intervention) and in 3 days (48 hours after first
intervention).
The outcomes to assess the effectiveness so far consist of the scores of symptoms and to
assess the safety of the drug will be accompanied by the emergence of adverse events.
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects [Recruiting]
Paracetamol overdose is the leading cause of acute liver failure in the Western World.
N-acetylcysteine (NAC) has been the antidote of choice for over 30 years but its use is
associated with adverse effects in 40% of cases. Patients characteristically experience
nausea, vomiting and an anaphylactoid ('pseudo-allergic') syndrome. This reaction is
clinically similar to true anaphylaxis (allergic reaction) including flushing, rash,
constriction of airways, and a fall in blood pressure, but occurs via a different mechanism.
Although treatable, these reactions lead to patient distress, commonly cause confusion among
treating physicians, and lead to significant delays in antidote administration. The
aetiology of these adverse reactions to NAC remains unclear. We hypothesise: i) these
reactions result from a dose-dependent release of the chemical histamine, causing dilatation
of blood vessels (vasodilatation) and the anaphylactoid syndrome; ii) paracetamol conversely
exerts a protective effect on the reaction, with a less severe reaction observed in the
presence of higher paracetamol concentrations. We will investigate the mechanisms underlying
adverse reactions to NAC in the human forearm model, examining the role of histamine and
other markers involved in the inflammatory process. The wider significance is an improved
understanding of this poorly delineated phenomenon, with implications for other medications
associated with similar reactions, such as non-steroidal anti-inflammatory drugs and opioids
such as morphine.
A One Year Trial Evaluating the Safety and Efficacy of the ALK House Dust Mite Allergy Tablet [Not yet recruiting]
The primary aim of this trial is to evaluate the efficacy of the ALK house dust mite tablet
given once daily compared to a placebo tablet in the treatment of house dut mite allergic
rhinits.
Additionally the secondary objective of the trial is to evaluate the safety and tolarability
of the ALK house dust mite tablet.
Immunotherapy has been shown to provide therapeutic benefits to subjects with house dust
mite induced allergy. This trial is planned to investigate if clinically relevant
improvements in rhinitis symptoms and with less use of symptomatic medication can be
obtained in subjects with a history of poor didease control despite of use of symptomatic
medications.
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