Chlordiazepoxide hydrochloride is the prototype for the benzodiazepine compounds. It is a versatile therapeutic agent of proven value for the relief of anxiety. Chlordiazepoxide hydrochloride is among the safer of the effective psychopharmacologic compounds available, as demonstrated by extensive clinical evidence.
Chlordiazepoxide HCl capsules USP are indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectiveness of chlordiazepoxide HCl capsules USP in long term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Published Studies Related to Chlordiazepoxide
A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol
withdrawal in a double blind design... CONCLUSION: Lorazepam is more effective than chlordiazepoxide in alcohol
Gabapentin versus chlordiazepoxide for outpatient alcohol detoxification
individuals randomized to treatment with gabapentin or chlordiazepoxide... CONCLUSIONS: In ambulatory veterans with symptoms of alcohol withdrawal,
A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. [2009.05]
CONCLUSIONS: With the treatment schedule used in this study, lorazepam is as effective as the more traditional drug chlordiazepoxide in attenuating uncomplicated alcohol withdrawal. Lorazepam, therefore, could be used with confidence when liver disease or the inability to determine liver function status renders chlordiazepoxide therapy problematic. The absence of clinically significant withdrawal complications with lorazepam in this large study contrasts with findings from previously published studies and suggests that higher doses of lorazepam than those formerly used may be necessary during alcohol withdrawal.
A double-blind randomized placebo-controlled trial of lofexidine in alcohol withdrawal: lofexidine is not a useful adjunct to chlordiazepoxide. [2001.09]
Lofexidine is an alpha-adrenoceptor agonist which has proved useful in opiate withdrawal and which, through its attenuation of noradrenergic activity, might be a valuable adjunct in the management of alcohol withdrawal. The objective of this study was to compare the clinical effectiveness and patient retention with adjunctive lofexidine versus placebo in the treatment of alcohol withdrawal under chlordiazepoxide cover...
The comparison of the effects of multi and single doses of buspirone, chlordiazepoxide and hydroxyzine on psychomotor function and EEG. 
This study compares the effects of buspirone (5 mg), chlordiazepoxide (5 mg), hydroxyzine (10 mg) and placebo on psychomotor function and EEG, when taken thrice daily for a period of two weeks, with those after a single dose administration... Spectral analysis of the EEG did not distinguish between the multi and single dosage schedules regarding the respective drugs in the low doses administered.
Clinical Trials Related to Chlordiazepoxide
Pioglitazone as an Adjunct for Moderate to Severe Depressive Disorder [Recruiting]
The purpose of this study is to determine whether Pioglitazone as an adjunct to Citalopram
is effective in treatment of moderate to severe depression
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation [Completed]
This study aims mainly to investigate the effects of two approaches to control blood pressure
in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume
control (by strict dietary salt restriction and persistent ultrafiltration) without using
antihypertensive drugs on cardiac structure and inflammation.
Results Of Patient Rated Asthma Control Test In Comparison To Diary Card Data [Completed]
The majority of asthma patients are not well controlled, despite the availability of asthma
medication that could effectively treat the disease. In this study uncontrolled patients who
are steroid-naive or on low dose inhaled corticosteroids will be treated with
Salmeterol/Fluticasone combination (SFC) 50/250 µg bd. The asthma control test (ACT) will be
used to detect differences in the level of asthma control during treatment. The study aims to
show a correlation between improvements of ACT und the level of asthma control which will be
reached by the patients.
The aim of the study is to show that most of symptomatic asthma patients can reach 'well
controlled asthma' with SFC. We get information about ACT in daily practice and physicians
are trained to use the asthma control test as a screening tool and for follow up of asthma
management. Correlations are expected between the improvements in ACT, Quality of Life and
asthma control according to the Gaining Optimal Asthma controL (GOAL) criteria.
Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study [Recruiting]
In a prospective and randomized study protocol, three different blood pressure regulating
agents (nitroprusside, nitroglycerine, sevoflurane) will be compared concerning their effect
on the cerebral oxygen balance between both hemispheres during aortic coarctation repair.
Cerebral and somatic saturation will be monitored non-invasively and continuously via
optical sensors applied to the right and left forehead and the somatic regions. Arterial
blood pressure, central venous pressure, heart rate and systemic saturation will be recorded
continuously. Intermittently, arterial and venous blood gas analysis will be performed at 6
definite time intervals. The study ends at the end of the operation.
Effect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 Diabetes [Recruiting]
This study in Germany is designed to compare the effects of twice-daily exenatide plus
metformin and twice-daily premixed human insulin aspart plus metformin with respect to
glycemic control, as measured by HbA1c, combined with the percentage of patients with at
least one treatment-emergent hypoglycemic episode. Patients will be treated with study
therapy for approximately 26 weeks.
Reports of Suspected Chlordiazepoxide Side Effects
Completed Suicide (11),
Toxicity TO Various Agents (11),
Drug Abuse (7),
Pneumonia Haemophilus (6),
Respiratory Acidosis (6),
Respiratory Failure (6),
Cardio-Respiratory Arrest (5),
Accidental Death (4),
Headache (4), more >>
Page last updated: 2014-11-30