Chlordiazepoxide and Amitriptyline (Chlordiazepoxide / Amitriptyline Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions to chlordiazepoxide and amitriptyline hydrochloride are those associated with the use of either component alone. Most frequently reported were drowsiness, dry mouth, constipation, blurred vision, dizziness and bloating. Other side effects occurring less commonly included vivid dreams, impotence, tremor, confusion and nasal congestion. Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness and lethargy, have been reported as side effects of treatment with both chlordiazepoxide and amitriptyline hydrochloride tablets and amitriptyline tablets.

Granulocytopenia, jaundice and hepatic dysfunction of uncertain etiology have also been observed rarely with chlordiazepoxide and amitriptyline hydrochloride. When treatment with chlordiazepoxide and amitriptyline hydrochloride is prolonged, periodic blood counts and liver function tests are advisable.

Note: Included in the listing which follows are adverse reactions which have not been reported with chlordiazepoxide and amitriptyline hydrochloride. However, they are included because they have been reported during therapy with one or both of the components or closely related drugs.

Cardiovascular: hypotension, hypertension, tachycardia, palpitations, myocardial infarction, arrhythmias, heart block, stroke

Psychiatric: euphoria, apprehension, poor concentration, delusions, hallucinations, hypomania and increased or decreased libido

Neurologic: incoordination, ataxia, numbness, tingling and paresthesias of the extremities, extrapyramidal symptoms, syncope, changes in EEG patterns

Anticholinergic: disturbance of accommodation, paralytic ileus, urinary retention, dilatation of urinary tract

Allergic: skin rash, urticaria, photosensitization, edema of face and tongue, pruritus

Hematologic: bone marrow depression including agranulocytosis, eosinophilia, purpura, thrombocytopenia

Gastrointestinal: nausea, epigastric distress, vomiting, anorexia, stomatitis, peculiar taste, diarrhea, black tongue

Endocrine: testicular swelling and gynecomastia in the male, breast enlargement, galactorrhea and minor menstrual irregularities in the female, elevation and lowering of blood sugar levels, and syndrome of inappropriate ADH (antidiuretic hormone) secretion

Other: headache, weight gain or loss, increased perspiration, urinary frequency, mydriasis, jaundice, alopecia, parotid swelling

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO CHLORDIAZEPOXIDE AND AMITRIPTYLINE

Possible Chlordiazepoxide and Amitriptyline side effects / adverse reactions in 39 year old male

Reported by a health professional (non-physician/pharmacist) from Australia on 2007-06-28

Patient: 39 year old male

Reactions: Electrocardiogram QT Prolonged, Electrocardiogram ST-T Change, Brugada Syndrome, Sudden Death

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Chlordiazepoxide and Amitriptyline
    Dosage: 200 mg, daily, unk
    Indication: Bipolar Disorder
    End date: 2006-01-01

Haloperidol
    Dosage: 10 mg, tid, unk
    Indication: Bipolar Disorder
    End date: 2006-01-01

Lithium Carbonate
    Dosage: 200 mg, bid, unk
    Indication: Bipolar Disorder
    End date: 2006-01-01

Valproate Sodium
    Dosage: 500 mg, bid, unk
    Indication: Bipolar Disorder
    End date: 2006-01-01