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Chlordiazepoxide and Amitriptyline (Chlordiazepoxide / Amitriptyline Hydrochloride) - Indications and Dosage

 
 



INDICATIONS AND USAGE

Chlordiazepoxide and amitriptyline hydrochloride tablets are indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

The therapeutic response to chlordiazepoxide and amitriptyline hydrochloride tablets occurs earlier and with fewer treatment failures than when either amitriptyline or chlordiazepoxide is used alone.

Symptoms likely to respond in the first week of treatment include: insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation and anorexia.

DOSAGE AND ADMINISTRATION

Optimum dosage varies with the severity of the symptoms and the response of the individual patient. When a satisfactory response is obtained, dosage should be reduced to the smallest amount needed to maintain the remission. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient. In general, lower dosages are recommended for elderly patients.

Chlordiazepoxide and amitriptyline hydrochloride tablets are recommended in an initial dosage of 3 or 4 tablets daily in divided doses; this may be increased to 6 tablets daily as required. Some patients respond to smaller doses and can be maintained on 2 tablets daily.

Chlordiazepoxide and amitriptyline hydrochloride tablets in an initial dosage of three or four tablets daily in divided doses may be satisfactory in patients who do not tolerate higher doses.

HOW SUPPLIED

Chlordiazepoxide and amitriptyline hydrochloride tablets are supplied as follows:

5 mg/ 12.5 mg tablets are peach colored, round, film coated tablets debossed “PAR” on one side and “265” on the other side. They are available in bottles of 100’s (NDC 49884-265-01).

10 mg/ 25 mg tablets are white, round, film coated tablets debossed “PAR” on one side and “266” on the other side. They are available in bottles of 100’s (NDC 49884-266-01).

Store at 25°C (77°F); excursions permitted to 15° – 30°C (59° - 86 °F). Store in a dry place.

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