NEWS HIGHLIGHTSMedia Articles Related to Chemet (Succimer)
Yale Researchers Succeed In Repairing Brain Damage Caused By Chronic Stress, Lead Poisoning, Potential Implications For Bipolar Disorder
Source: Bipolar News From Medical News Today [2009.09.10]
Yale University researchers report in the Proceedings of the National Academy of Sciences (September 7-11 edition) that damage to the brain caused by chronic stress or lead poisoning can be repaired by blocking a key molecular pathway. Research shows that rats exposed to chronic stress develop damage to the prefrontal cortex. This is an area of the brain essential to working memory, impulse control and the ability to stay focused on tasks.
Chelation Therapy Drug Found Safe And Beneficial For Children With Autism
Source: Autism News From Medical News Today [2009.11.06]
Two studies published by the Southwest College of Naturopathic Medicine in the October issue of BMC Clinical Pharmacology investigated the use of oral dimercaptosuccinic acid (DMSA), a prescription medicine approved by the FDA for treating lead poisoning, and used off-label in these studies for treating heavy metal toxicity in children with autism. In the investigations, DMSA was given to 65 children with autism (ages 3 -8 years) to determine its effects.
Yale Researchers Repair Brain Damage Caused By Chronic Stress Work Has Implications For Bipolar Disorder, PTSD
Source: Bipolar News From Medical News Today [2009.09.09]
Damage to the brain caused by chronic stress or lead poisoning can be repaired by blocking a key molecular pathway, Yale University researchers report in the September 7-11 edition of the Proceedings of the National Academy of Sciences. Rats subjected to chronic stress develop damage to the prefrontal cortex, an area of the brain crucial to working memory, impulse control and the ability to stay focused on tasks.
Published Studies Related to Chemet (Succimer)
Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead. [2007.05]
This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnati enrolled in a randomized, placebo-controlled, double blind clinical trial...
Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead. [2007.03.31]
This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnati enrolled in a randomized, placebo-controlled, double blind clinical trial...
Effect of succimer on growth of preschool children with moderate blood lead levels. [2004.02]
Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 microg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial...
The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. [2001.05.10]
BACKGROUND: Thousands of children, especially poor children living in deteriorated urban housing, are exposed to enough lead to produce cognitive impairment. It is not known whether treatment to reduce blood lead levels prevents or reduces such impairment... CONCLUSIONS: Treatment with succimer lowered blood lead levels but did not improve scores on tests of cognition, behavior, or neuropsychological function in children with blood lead levels below 45 microg per deciliter. Since succimer is as effective as any lead chelator currently available, chelation therapy is not indicated for children with these blood lead levels.
A comparison of two dosing regimens of succimer in children with chronic lead poisoning. [1999.02]
There is limited information defining the optimal dosing regimen of succimer in the treatment of children with chronic lead poisoning. It is typically administered as a five day course of high dose therapy (1,050 mg/m2/day) followed by 14 days of low dose therapy (700 mg/m2/day)... Because of the small size of this study, other studies are warranted.
Clinical Trials Related to Chemet (Succimer)
Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children [Completed]
OBJECTIVES:
Compare growth of lead-poisoned children receiving succimer (dimercaptosuccinic acid; DMSA)
plus standard treatment to those receiving standard treatment only.
The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning [Completed]
Lead poisoning remains a common disease among children despite successful public health
efforts that reduced its prevalence. Our study was designed to test the hypothesis that
lead-poisoning children (BLLs: 100-440µg/L) who were given DMSA and multi-nutrients would have
a greater fall than children of other groups at 12 weeks of follow-up.
Mercury Chelation to Treat Autism [Recruiting]
This study will examine whether DMSA, an oral chelating agent that removes mercury and other
metals from the body, is beneficial for children with autism. DMSA is commonly used to treat
autism, although it has never been tested in a controlled study and there is no proof that it
helps children with the disorder. Support for its use is based on single-case reports of
benefits of chelation with DMSA. This study will help determine whether or not DMSA is useful
for treating autism.
Children between 4 and 10 years of age with autism spectrum disorder who weigh at least 33
pounds, who have detectable, but not toxic, levels of mercury or lead in the blood, and who
have not previously received chelation therapy may be eligible for this study.
Participants complete a medical history, behavioral and psychological assessment and physical
examination. Blood, hair, urine and stool samples are collected for testing.
Because DMSA can remove minerals the body needs, such as zinc and iron, as well as the toxic
lead and mercury, participants take a daily multivitamin supplement starting 1 month before
beginning chelation therapy and continuing for the duration of treatment. After 1 month of
the supplementation regimen, the children are assigned to receive DMSA or placebo for 12
weeks, divided into six 2-week cycles. They take the assigned drug 3 times a day on days 1, 2
and 3 of each cycle and continue the multivitamin every day.
The children are seen in the clinic immediately before and after the first, third and sixth
cycles. At each checkup, the parent or guardian answers a set of questions about the child's
autism symptoms, physical health and medication side effects. Blood, urine and stool samples
are collected for laboratory testing.
Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old [Recruiting]
The purpose of this study is to demonstrate the equivalence of the therapeutic efficacy of
cefixime by mouth (PO) 10 days (d) and ceftriaxone intravenous (IV) 4d followed by cefixime
PO 6d on renal scars 6 months after a first acute pyelonephritis episode.
The investigators hypothesize that treatment with cefixime PO will allow no more renal scars
than IV treatment of pyelonephritis in infants and children less than 3 years old, 6 months
after the first episode. If it is true, treatment will no longer need hospitalisation and the
advantages for children, families and the health system will be very important.
Antibiotic Prophylaxis in Children With Pyelonephritis [Recruiting]
Children who present with pyelonephritis undergo many investigations, and long term care to
prevent renal damage. The focus is primarily on preventing renal failure however along the
way and particularly with children, other issues arise which impact their lives, as well as
their family's lives. Parents are concerned about subjecting their children to invasive
procedures and long term antibiotic use, particularly if they are not sure of the benefit.
This study seeks to provide information on the impact of investigation and long term
antibiotic treatment in reference to long term health and quality of life in children who
present with febrile urinary tract infections in the absence of anatomic abnormalities.
|
