Media Articles Related to Ceprotin (Protein C)
Protein controls both alcohol craving and organ damage
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.02.16]
Study suggests targeting RGS6 protein might allow treatment of alcoholism and simultaneously prevent alcohol-induced heart and liver damageWhat if there was a drug that could simultaneously curb...
New insight into a fragile protein linked to cancer and autism
Source: Autism News From Medical News Today [2015.02.20]
In recent years, scientists have found a surprising connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical...
Treatments to stop Alzheimer's step closer as scientists discover key inhibitor molecule
Source: Biology / Biochemistry News From Medical News Today [2015.02.18]
Scientists have identified a molecule that breaks the cycle of protein clumping that kills brain cells in Alzheimer's disease. They say it should be possible to find more like it.
Spanish scientists modify with pulsed light the protein that causes most allergies to milk
Source: Allergy News From Medical News Today [2015.02.06]
The investigators, who belong to the University of Granada and the Azti-Tecnalia technology centre, have artificially modified a type of lactose protein called beta-lactoglobulinThese are the...
New protein detonates 'invincible' bacteria from within
Source: MRSA / Drug Resistance News From Medical News Today [2015.01.31]
Tel Aviv University researchers identify protein capable of neutralizing antibiotic-resistant bacterial cellsAntibiotic-resistant infections are on the rise, foiling efforts to reduce death rates...
Published Studies Related to Ceprotin (Protein C)
Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. [2011.09]
Chronic wounds arising from orthopedic surgery present a major clinical challenge. Osteomyelitis may develop from polymicrobial infection, which can be unresponsive to treatment and lead to amputation...
A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. [2011.08]
OBJECTIVE: To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma. BACKGROUND: Hyperinflammation and acute coagulopathy of trauma predict increased mortality. High catecholamine levels can directly damage the endothelium and may be associated with enhanced endothelial glycocalyx degradation, evidenced by high circulating syndecan-1... CONCLUSIONS: In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality.
Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. [2011.04.15]
RATIONALE: Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe direct lung injury may decrease mortality. OBJECTIVES: Determine the clinical benefit of administering an rSP-C-based synthetic surfactant to patients with severe direct lung injury due to pneumonia or aspiration... CONCLUSIONS: In this study, rSP-C-based surfactant was of no clinical benefit to patients with severe direct lung injury. The unexpected lack of improvement in oxygenation, coupled with the results of in vitro tests, suggest that the administered suspension may have had insufficient surface activity to achieve clinical benefit.
Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism. 
INTRODUCTION: There are no published data on the status of endogenous activated protein C (APC) in pulmonary embolism (PE), and no data on the effect of drotrecogin alfa (activated) (DAA) given in addition to therapeutic dose enoxaparin... CONCLUSIONS: In patients with acute submassive PE endogenous APC levels are low. DAA infusion enhances the inhibition of fibrin formation. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00191724.
Combination of activated protein C and topical negative pressure rapidly
regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic
Chronic wounds arising from orthopedic surgery present a major clinical
challenge. Osteomyelitis may develop from polymicrobial infection, which can be
unresponsive to treatment and lead to amputation...
Clinical Trials Related to Ceprotin (Protein C)
Ceprotin Treatment Registry [Recruiting]
Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. [Recruiting]
The purpose of this study is to investigate the effects on systemic hemodynamics,
microcirculation and organ function of human Protein C concentrate in patients with sepsis
and septic shock.
Activated Protein C and Corticosteroids for Human Septic Shock [Recruiting]
This study aims at comparing the efficacy and safety of recombinant human activated protein
C to that of low dose of corticosteroids and at investigating the interaction between these
drugs in the management of septic shock
Safety Evaluation of 3K3A-APC in Ischemic Stroke [Recruiting]
The purpose of this study is to evaluate the safety, pharmacokinetics (PK) and preliminary
efficacy of multiple ascending intravenous doses of 3K3A-APC, a Recombinant Variant of Human
activated protein C (APC), in in the treatment of acute ischemic stroke following treatment
with recombinant tissue plasminogen activator (tPA).
Effect of APC and Epo on the Inflammatory Response During Sepsis [Recruiting]