Media Articles Related to Ceprotin (Protein C)
Consuming too much wheat flour and animal protein could have profound effects on kidney health
Source: Hypertension News From Medical News Today [2013.11.12]
Three new studies suggest that controlling dietary acid intake could help improve kidney health. Results of these studies will be presented at ASN Kidney Week 2013 November 5-10 at the Georgia World Congress Center in Atlanta, GA.A diet rich in wheat flour and animal protein produces an acidic environment in the body that worsens with age as kidney function declines.
Newly identified protein could be a cancer key
Source: Biology / Biochemistry News From Medical News Today [2013.11.01]
Scientists at the University of Dundee have identified a protein that could be key in the fight against cancer.Researchers in the College of Life Sciences at Dundee have demonstrated that cancer cells need a protein called Bod1 to grow and divide. When this protein is removed cancer cells lose control of cell division and die.
Discovery Of Defective Regulatory Protein Could Increase Efficacy Of Promising Cystic Fibrosis Drug
Source: Cystic Fibrosis News From Medical News Today [2013.03.26]
A little more than a year after the FDA approved Kalydeco (Vx-770), the first drug of its kind to treat the underlying cause of cystic fibrosis, University of Missouri researchers believe they have found exactly how this drug works and how to improve its effectiveness in the future.
Alternate pathway for drug development to fight HIV
Source: Genetics News From Medical News Today [2013.11.27]
A collaborative team led by a Northeastern University professor may have altered the way we look at drug development for HIV by uncovering some unusual properties of a human protein called APOBEC3G (A3G).In an article published in Nature Chemistry, Prof.
Notch signaling pathway keeps immature T cells on the right track
Source: Cancer / Oncology News From Medical News Today [2013.11.26]
The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. T cells are immune cells that are made in the thymus, a small organ situated under the breastbone near the heart.
Published Studies Related to Ceprotin (Protein C)
Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. [2011.09]
Chronic wounds arising from orthopedic surgery present a major clinical challenge. Osteomyelitis may develop from polymicrobial infection, which can be unresponsive to treatment and lead to amputation...
A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. [2011.08]
OBJECTIVE: To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma. BACKGROUND: Hyperinflammation and acute coagulopathy of trauma predict increased mortality. High catecholamine levels can directly damage the endothelium and may be associated with enhanced endothelial glycocalyx degradation, evidenced by high circulating syndecan-1... CONCLUSIONS: In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality.
Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. [2011.04.15]
RATIONALE: Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe direct lung injury may decrease mortality. OBJECTIVES: Determine the clinical benefit of administering an rSP-C-based synthetic surfactant to patients with severe direct lung injury due to pneumonia or aspiration... CONCLUSIONS: In this study, rSP-C-based surfactant was of no clinical benefit to patients with severe direct lung injury. The unexpected lack of improvement in oxygenation, coupled with the results of in vitro tests, suggest that the administered suspension may have had insufficient surface activity to achieve clinical benefit.
Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism. 
INTRODUCTION: There are no published data on the status of endogenous activated protein C (APC) in pulmonary embolism (PE), and no data on the effect of drotrecogin alfa (activated) (DAA) given in addition to therapeutic dose enoxaparin... CONCLUSIONS: In patients with acute submassive PE endogenous APC levels are low. DAA infusion enhances the inhibition of fibrin formation. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00191724.
Combination of activated protein C and topical negative pressure rapidly
regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic
Chronic wounds arising from orthopedic surgery present a major clinical
challenge. Osteomyelitis may develop from polymicrobial infection, which can be
unresponsive to treatment and lead to amputation...
Clinical Trials Related to Ceprotin (Protein C)
Ceprotin Treatment Registry [Recruiting]