CENTANY SUMMARY
CENTANY™
(mupirocin ointment),2%
Each gram of Centany (mupirocin ointment),2% contains 20 mg mupirocin in a soft white ointment base consisting of castor oil, oleyl alcohol, hard fat (Softisan® 378) and propylene glycol monostearate. Mupirocin is a naturally occurring antibiotic.
Centany (mupirocin ointment),2% is indicated for the topical treatment of impetigo due to: Staphylococcus aureus and Streptococcus pyogenes.
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NEWS HIGHLIGHTSMedia Articles Related to Centany (Mupirocin Topical)
mupirocin, mupirocin calcium, Bactroban, Bactroban Nasal, Centany
Source: MedicineNet Atopic Dermatitis Specialty [2009.02.19]
Title: mupirocin, mupirocin calcium, Bactroban, Bactroban Nasal, Centany
Category: Medications
Created: 12/31/1997
Last Editorial Review: 2/19/2009
Published Studies Related to Centany (Mupirocin Topical)
Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis. [2008.09]
OBJECTIVES/HYPOTHESIS: To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection. STUDY DESIGN: Prospective open-label pilot study... CONCLUSIONS: Nasal Lavage with 0.05% Mupirocin may represent an effective and well tolerated alternative treatment for postsurgical recalcitrant CRS.
A RANDOMIZED CONTROLLED TRIAL COMPARING MUPIROCIN VERSUS POLYSPORIN TRIPLEa FOR THE PREVENTION OF CATHETER-RELATED INFECTIONS IN PERITONEAL DIALYSIS PATIENTS (THE MP3 STUDY). [2008.01]
BACKGROUND: Peritonitis remains the most serious complication of peritoneal dialysis (PD). Gram-positive organisms are among the most common causes of PD peritonitis; however, recent trends show increasing rates of gram-negative and fungal infections.Discussion: The results of this study will help determine if the use of P3 is superior to mupirocin ointment in the prevention of catheter-related infections and will help guide evidence-based best practices.
Effect of once-a-week vs thrice-a-week application of mupirocin on methicillin and mupirocin resistance in peritoneal dialysis patients: three years of experience. [2008]
INTRODUCTION: The application of mupirocin to the exit-site in peritoneal dialysis (PD) patients decreases peritonitis and exit-site infection (ESI) considerably. However, long-term application of mupirocin may result in the development of methicillin- and mupirocin-resistant strains. In this study, we aimed to investigate the effect of once-a-week vs. thrice-a-week application of mupirocin on mupirocin and methicillin resistance in PD patients... CONCLUSION: The thrice-a-week application of mupirocin seems to be more efficient when compared to once-a-week application of mupirocin. Long-term application of mupirocin may cause the development of mupirocin- and methicillin-resistant strains, especially in CNS, which results in a difficulty for struggling against infections.
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. [2007.01.15]
BACKGROUND: Eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage may reduce the risk of MRSA infection and prevent transmission of the organism to other patients... CONCLUSIONS: Treatment with topical mupirocin, chlorhexidine gluconate washes, oral rifampin, and doxycycline for 7 days was safe and effective in eradicating MRSA colonization in hospitalized patients for at least 3 months.
Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. [2005.05]
The clinical usefulness of hemodialysis catheters is limited by increased infectious morbidity and mortality... The effectiveness of honey against antibiotic-resistant microorganisms and its low likelihood of selecting for further resistant strains suggest that this agent may represent a satisfactory alternative means of chemoprophylaxis in patients with central venous catheters.
Clinical Trials Related to Centany (Mupirocin Topical)
Prophylaxis With Intranasal Mupirocin for Prevention of S. Aureus Infections [Completed]
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on
subsequent Staphylococcus aureus infection, a prospective randomized trial was performed
particularly including patients with predisposing risk factors for S. aureus infections.
Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis [Not yet recruiting]
Catheter-related infection, namely exit site infection and peritonitis, is the commonest
complication of peritoneal dialysis. This complication causes significant morbidity and
mortality in patients requiring peritoneal dialysis. Topical application of mupirocin 2%
cream was first proven to be effective in reduction of staphylococcus-related catheter
infection in 1990s. Subsequent randomized trial published in 2005 showed that gentamicin
cream was superior to mupirocin 2% cream in reducing both Gram's positive and Gram's
negative related catheter infection. However, a retrospective report published in 2007 puts
the use of prophylactic antibiotic cream into a question. It reported an emergency of
non-tuberculous mycobacterial infection in a dialysis center in Hong Kong after practising
prophylactic application of gentamicin cream at the catheter exit site. The following
prospective, randomized and open-label study aims to find out an optimal regimen of topical
antibiotic prophylaxis in patients requiring peritoneal dialysis.
Preventing Staphylococcal (Staph) Infection [Recruiting]
Use of Ointments in Prevention of Catheter Related Infections in PD [Recruiting]
Peritoneal dialysis (PD) is used for the treatment of end-stage renal disease in
approximately 25% of patients requiring dialysis in Canada. The most common complication is
bacterial infection or ‘peritonitis’. Peritonitis causes severe acute abdominal pain and may
lead to failure of peritoneal dialysis treatment, hospitalization or death, particularly if
left untreated. Amongst the strategies used to prevent peritonitis, patients are instructed
on the regular use of a prophylactic ointment around the point where the catheter exits from
the body. At the present time most centers in Canada routinely prescribe mupirocin ointment
for use at the exit site, however newer ointments have become available. One such ointment
is Polysporin Triple. The aim of this study is to determine if catheter related infections
can be significantly reduced by the routine application of Polysporin Triple in comparison to
mupirocin ointment. A multi-centre, randomized, double blind, controlled study is proposed.
Participants will be randomized to either mupirocin or Polysporin Triple and followed for 18
months or until the first catheter related infection, death or catheter removal. The
difference in catheter related infection rates will be compared between the two groups. We
anticipate the results of this study will allow clinicians to prescribe the ointment most
likely to reduce infections. By doing so this will reduce the complication rate associated
with peritoneal dialysis and, ultimately improve survival.
Prophylaxis Prior to Cataract Surgery Conjunctival Flora and Optimal Ocular Sterilization Technique Prior to Cataract Surgery [Completed]
The purpose of this study is to evaluate the conjunctival flora prior to cataract or
vitrectomy surgery comparing mupirocin ointment applied to the conjunctiva along with
standard ocular sterilization vs. standard ocular sterilization alone.
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