NEWS HIGHLIGHTSMedia Articles Related to Celontin (Methsuximide)
Increased Risk Of Seizures Faced By Current Cigarette Smokers
Source: Health News from Medical News Today [2009.11.19]
A recent study determined there is a significant risk of seizure for individuals who currently smoke cigarettes. Boston-based researchers from Brigham and Women's Hospital and Harvard Medical School also found that long-term, moderate intake of caffeine or alcohol does not increase the chance of having a seizure or developing epilepsy.
Improved Understanding Of Why Seizures Occur With Alcohol Withdrawal
Source: Epilepsy News From Medical News Today [2009.10.19]
Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long-term or chronic drinking habit. Researchers have shown that the flow of calcium ions into brain cells via voltage-gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures.
Gene Mutation Linked to Fever-Induced Seizures
Source: MedicineNet Seizure Specialty [2009.09.21]
Title: Gene Mutation Linked to Fever-Induced Seizures
Category: Health News
Created: 9/18/2009 2:10:00 PM
Last Editorial Review: 9/21/2009
Febrile Seizures And Severe Epilepsy In Infants Traced To A Sodium Channel Gene Mutation
Source: Epilepsy News From Medical News Today [2009.09.20]
Mutations in the SCN9A sodium channel gene are a cause of febrile seizures and contribute to a severe form of epilepsy in infants 6 months and younger, report researchers from the University of Utah, University of Antwerp, and University of Washington.
Febrile Seizures
Source: MedicineNet Pediatric Epilepsy Surgery Specialty [2008.05.09]
Title: Febrile Seizures
Category: Diseases and Conditions
Created: 5/9/2008
Last Editorial Review: 5/9/2008
Published Studies Related to Celontin (Methsuximide)
Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. [2001.03]
The efficacy and safety of methsuximide (MSM) was evaluated in children with intractable epilepsies in a prospective uncontrolled study. MSM was added to the therapeutic regimen of 112 children with intractable epilepsy under inpatient conditions, all of whom were therapeutically refractory to various first-line antiepileptic drugs (AED) or combinations of other AED...
Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. [2000.05]
PURPOSE: To determine whether methsuximide (MSM) affects lamotrigine (LTG) blood levels and whether any change is of clinical significance... CONCLUSIONS: Although MSM is a valuable add-on, broad-spectrum drug when used in combination with LTG, adjustment of the LTG dose may be necessary when MSM is started or stopped, to allow for the fact that MSM lowers LTG blood levels.
Serum protein binding of desmethyl-methsuximide. [1999.07]
Serum protein binding of desmethyl-methsuximide (DM-MSM) in serum from 23 patients on polytherapy were determined using ultrafiltration and high-performance liquid chromatography. Desmethyl-methsuximide, The active metabolite of methsuximide (MSM), was found to have a moderate protein binding ranging between 45% and 60%..
Methsuximide therapy of juvenile myoclonic epilepsy. [1996.03]
Currently valproic acid is considered to be the drug of first choice for juvenile myoclonic epilepsy (JME) resulting in a 70-90% control rate for all seizure types associated with JME. In those situations where valproic acid fails to control seizure activity, results in unacceptable side-effects, or is declined due to potential side-effects, an alternative effective monotherapy would be desirable...
Methsuximide for intractable childhood seizures. [1991.02]
Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency... Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.
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