NEWS HIGHLIGHTSMedia Articles Related to Celontin (Methsuximide)
Implanted Device Predicts Epilepsy Seizures In Humans
Source: Epilepsy News From Medical News Today [2013.05.02]
For the first time, a small device implanted in the brain has accurately predicted the onset of seizures in some adults who have epilepsy that doesn't respond to drugs, according to a small proof-of-concept study published Online First in The Lancet Neurology...
Implanted Device May Predict Epilepsy Seizures, Study Suggests
Source: MedicineNet Seizure Specialty [2013.05.02]
Title: Implanted Device May Predict Epilepsy Seizures, Study Suggests
Category: Health News
Created: 5/2/2013 10:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM
Experimental Treatment For Rare Pediatric 'Pretzel Syndrome' Halts Intractable Seizures
Source: Epilepsy News From Medical News Today [2013.04.26]
With a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully treated with a drug that modifies the disease process, minimizing seizures and improving receptive language...
TBI Increases Odds For Depression, Behavior Impulsivity, PTSD In Patients With Nonepileptic Seizures
Source: Epilepsy News From Medical News Today [2013.04.10]
A new study by a Rhode Island Hospital researcher has found that traumatic brain injury (TBI) can significantly increase the odds of having major depression, personality impulsivity and post-traumatic stress disorder (PTSD) in patients with psychogenic nonepileptic seizures (PNES). The paper, by W. Curt LaFrance Jr., M.D., M.P.H...
Prolonged Seizures In Children And Developmental Delays
Source: Epilepsy News From Medical News Today [2013.04.10]
Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus (CSE) - a seizure lasting longer than thirty minutes...
Published Studies Related to Celontin (Methsuximide)
Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. [2001.03]
The efficacy and safety of methsuximide (MSM) was evaluated in children with intractable epilepsies in a prospective uncontrolled study. MSM was added to the therapeutic regimen of 112 children with intractable epilepsy under inpatient conditions, all of whom were therapeutically refractory to various first-line antiepileptic drugs (AED) or combinations of other AED...
Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. [2000.05]
PURPOSE: To determine whether methsuximide (MSM) affects lamotrigine (LTG) blood levels and whether any change is of clinical significance... CONCLUSIONS: Although MSM is a valuable add-on, broad-spectrum drug when used in combination with LTG, adjustment of the LTG dose may be necessary when MSM is started or stopped, to allow for the fact that MSM lowers LTG blood levels.
Serum protein binding of desmethyl-methsuximide. [1999.07]
Serum protein binding of desmethyl-methsuximide (DM-MSM) in serum from 23 patients on polytherapy were determined using ultrafiltration and high-performance liquid chromatography. Desmethyl-methsuximide, The active metabolite of methsuximide (MSM), was found to have a moderate protein binding ranging between 45% and 60%..
Methsuximide therapy of juvenile myoclonic epilepsy. [1996.03]
Currently valproic acid is considered to be the drug of first choice for juvenile myoclonic epilepsy (JME) resulting in a 70-90% control rate for all seizure types associated with JME. In those situations where valproic acid fails to control seizure activity, results in unacceptable side-effects, or is declined due to potential side-effects, an alternative effective monotherapy would be desirable...
Methsuximide for intractable childhood seizures. [1991.02]
Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency... Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.
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