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Cefazolin (Cefazolin Sodium) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The following reactions have been reported:

Gastrointestinal: Diarrhea, oral candidiasis (oral thrush), vomiting, nausea, stomach cramps, anorexia, and pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see  WARNINGS). Nausea and vomiting have been reported rarely.

Allergic: Anaphylaxis, eosinophilia, itching, drug fever, skin rash, Stevens-Johnson syndrome.

Hematologic: Neutropenia, leukopenia, thrombocytopenia, thrombocythemia.

Hepatic: Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been observed. As with other cephalosporins, reports of hepatitis have been received.

Renal: As with other cephalosporins, reports of increased BUN and creatinine levels, as well as renal failure, have been received.

Local Reactions: Rare instances of phlebitis have been reported at site of injection. Pain at the site of injection after intramuscular administration has occurred infrequently. Some induration has occurred.

Other Reactions: Genital and anal pruritus (including vulvar pruritus, genital moniliasis, and vaginitis).
   Cephalosporin-class Adverse Reactions

In addition to the adverse reactions listed above that have been observed in patients treated with cefazolin, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Adverse Reactions: Allergic reactions, urticaria, serum sickness-like reaction, erythema multiforme, toxic epidermal necrolysis, colitis, renal dysfunction, toxic nephropathy, abdominal pain, reversible hyperactivity, hypertonia, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhage, and superinfection.

Altered Laboratory Tests: Prolonged prothrombin time, positive direct Coomb’s test, false-positive test for urinary glucose, elevated bilirubin, elevated LDH, increased creatinine, pancytopenia, and agranulocytosis.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (See  DOSAGE AND ADMINISTRATION). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.




REPORTS OF SUSPECTED CEFAZOLIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Cefazolin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Cefazolin side effects / adverse reactions in 24 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2011-10-03

Patient: 24 year old male

Reactions: Drug Eruption, Ear Haemorrhage, Symblepharon, Conjunctivitis, Tear Discolouration, Periorbital Haematoma, DRY Eye, Epistaxis

Suspect drug(s):
Cefazolin



Possible Cefazolin side effects / adverse reactions in 15 year old male

Reported by a health professional (non-physician/pharmacist) from Singapore on 2011-10-05

Patient: 15 year old male

Reactions: Periorbital Oedema

Suspect drug(s):
Ciprobay 100 Infusion 100 Mg/50 ML

Amoxicillin

Cefazolin

Erythromycin

Clindamycin

Vancomycin



Possible Cefazolin side effects / adverse reactions in 45 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-07

Patient: 45 year old male weighing 80.0 kg (176.0 pounds)

Reactions: Respiratory Disorder, Skin Exfoliation, Effusion, Petechiae, Pyrexia, Erythema, LIP Erosion, Multi-Organ Failure, Skin Lesion, Erythema Multiforme, Blister, Pneumonia, Retinal Haemorrhage, Toxic Epidermal Necrolysis, Rash, Skin Plaque, Nikolsky's Sign, Staphylococcal Infection, Ocular Hyperaemia, Scrotal Ulcer, Skin Erosion, Blood Pressure Decreased

Adverse event resulted in: death

Suspect drug(s):
Meropenem
    Dosage: .5g per day
    Indication: Infection
    Start date: 2009-08-16
    End date: 2009-08-20

Cefazolin
    Dosage: 1g per day
    Start date: 2009-07-31
    End date: 2009-07-31

Piperacillin Sodium
    Dosage: 2g per day
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-07-31
    End date: 2009-07-31

Piperacillin Sodium
    Dosage: 4g per day
    Start date: 2009-08-01
    End date: 2009-08-10

Phenytoin Sodium CAP
    Dosage: 125mg per day
    Start date: 2009-08-20
    End date: 2009-08-20

Zantac
    Dosage: 200mg per day
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-07-25
    End date: 2009-08-13

Meropenem
    Dosage: .5g per day
    Start date: 2009-08-24
    End date: 2009-08-24

Cefazolin
    Dosage: 2g twice per day
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-07-25
    End date: 2009-07-30

Meropenem
    Dosage: 1g per day
    Start date: 2009-08-21
    End date: 2009-08-23

Phenytoin Sodium CAP
    Dosage: 250mg per day
    Indication: Grand MAL Convulsion
    Start date: 2009-08-15
    End date: 2009-08-19

Firstcin
    Dosage: 1g per day
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-08-11
    End date: 2009-08-11

Firstcin
    Dosage: .5g per day
    Start date: 2009-08-12
    End date: 2009-08-14

Other drugs received by patient: Bisolvon; Vitaject; Elemenmic; Coniel; Nafamostat Mesilate; Heparin Sodium; Methoxamine Hydrochloride; Nicardipine HCL; Calcium Carbonate; Midazolam HCL; Norepinephrine Bitartrate; Vitamedin; Unknown; Bisolvon; Unknown; Propofol; Potassium Chloride; Midazolam HCL; Heparin Sodium; Millisrol (Japan); Furosemide; Furosemide; Ephedrine Hydrochloride; NEO-Minophagen-C; Elaspol; Midazolam HCL; Hicaliq; Vitaject; Heparin Sodium; Buprenorphine HCL; Midazolam HCL; Heparin Sodium; Urso 250; LAC B; Biofermin; Stadol; Dobutrex; Pantol; Pantol; Hicaliq; Elemenmic; Urso 250; Lendormin; Dopamine HCL; Ketalar; Stadol; Neoamiyu; Neoamiyu; Heparin Sodium; Unknown; Nicardipine HCL



See index of all Cefazolin side effect reports >>

Drug label data at the top of this Page last updated: 2012-04-12

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