Cefadroxil (Cefadroxil Hemihydrate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Gastrointestinal

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS). Dyspepsia, nausea and vomiting have been reported rarely. Diarrhea has also occurred.

Hypersensitivity

Allergies (in the form of rash, urticaria, angioedema, and pruritus) have been observed. These reactions usually subsided upon discontinuation of the drug. Anaphylaxis has also been reported.

Other

Other reactions have included hepatic dysfunction including cholestasis and elevations in serum transaminase, genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Agranulocytosis, thrombocytopenia,idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia have been rarely reported.

In addition to the adverse reactions listed above which have been observed in patients treated with cefadroxil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs’ test, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated bilirubin, elevated LDH, eosinophilia, pancytopenia, neutropenia.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced (see DOSAGE AND ADMINISTRATION and OVERDOSAGE). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO CEFADROXIL

Possible Cefadroxil side effects / adverse reactions in 36 year old female

Reported by a individual with unspecified qualification from Sweden on 2007-06-25

Patient: 36 year old female

Reactions: Vomiting, Nausea, Pregnancy Induced Hypertension, Antepartum Haemorrhage, Platelet Aggregation Decreased, Activated Partial Thromboplastin Time Prolonged, Caesarean Section, Drug Exposure During Pregnancy, Proteinuria, Bleeding Time Prolonged, Haemorrhagic Diathesis, Anaemia of Pregnancy, PRE-Eclampsia, Thrombocytopenia, Epistaxis

Adverse event resulted in: hospitalization

Suspect drug(s):
Paroxetine Hydrochloride
    Indication: Depression

Buspirone (Formulation Unknown) (Buspirone)

Iron Supplements Tablet (Iron Supplements)
    Dosage: oral
    Administration route: Oral
    Indication: Anaemia

Pindolol
    Dosage: 10 mg/ per day
    Indication: Hypertension

Venofer
    Indication: Anaemia

Cefadroxil
    Dosage: 1 gram(s) / see dosage text

Desmopressin Acetate

Possible Cefadroxil side effects / adverse reactions in 36 year old female

Reported by a consumer/non-health professional from Sweden on 2007-06-26

Patient: 36 year old female

Reactions: Vomiting, Nausea, Anaemia, Nitrite Urine Present, Drug Exposure During Pregnancy, Proteinuria, Haemorrhagic Diathesis, PRE-Eclampsia, Thrombocytopenia, Hypertension, Epistaxis

Adverse event resulted in: hospitalization

Suspect drug(s):
Paroxetine HCL
    Indication: Depression

Buspirone
    Dosage: 60mg per day

FE 2+ Supplement
    Administration route: Oral

Pindolol
    Dosage: 10mg per day
    Indication: Hypertension

Venofer

Cefadroxil
    Dosage: 1g see dosage text

Desmopressin

Possible Cefadroxil side effects / adverse reactions in 61 year old male

Reported by a health professional (non-physician/pharmacist) from Finland on 2007-07-05

Patient: 61 year old male

Reactions: Metabolic Acidosis, Hyperkalaemia, Renal Failure Acute

Adverse event resulted in: life threatening event

Suspect drug(s):
Cefadroxil

Other drugs received by patient: Warfarin Sodium; Ramipril; Digoxin; Spironolactone; Metoprolol Succinate