CECLOR SUMMARY
Ceclor® (Cefaclor, USP) is a semisynthetic cephalosporin antibiotic for oral administration.
Ceclor is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms:
Otitis media
caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenes Note: (beta)-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to cefaclor despite apparent in vitro susceptibility of some BLNAR strains.
Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes Note: (beta)-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to cefaclor despite apparent in vitro susceptibility of some BLNAR strains.
Pharyngitis and Tonsillitis, caused by Streptococcus pyogenes Note: Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Ceclor is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of Ceclor in the subsequent prevention of rheumatic fever are not available at present.
Urinary tract infections, including pyelonephritis and cystitis, caused by Escherichia coli, Proteus mirabilis, Klebsiella spp., and coagulase-negative staphylococci
Skin and skin structure infections
caused by Staphylococcus aureus and Streptococcus pyogenes
Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to cefaclor.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ceclor and other antibacterial drugs, Ceclor should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
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NEWS HIGHLIGHTS
Published Studies Related to Ceclor (Cefaclor)
Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. [2010.01.08] BACKGROUND AND AIMS: In rodents, cephalosporin antibiotics can mimic peptones and stimulate release of cholecystokinin (CCK), a hormone that slows gastric emptying. The rate of gastric emptying is a major determinant of postprandial blood glucose and insulin concentrations. We therefore evaluated the effect of orally administered cefaclor on plasma CCK and gastric emptying, as well as postprandial glycemic and insulinemic responses, in healthy humans... CONCLUSION: Cefaclor, when given before a meal in the form of a capsule, does not stimulate CCK release or slow gastric emptying in healthy humans.
[Comparative study on cefdinir and cefaclor in the treatment of patients with mild to moderate bacterial community acquired pneumonia.] [2004.11.17] OBJECTIVE: To evaluate the efficacy and safety of cefdinir in the treatment of patients with mild to moderate bacterial community acquired pneumonia (CAP)... CONCLUSION: cefdinir is safe and effective, shorten the course of treatment in the treatment of mild to moderate bacterial community acquired pneumonia.
Clarithromycin suspension: bioequivalence studies on two different strengths. [2004.09] Two studies were performed in different groups of volunteers, with the aim to prove the bioequivalence of test (Klaromin) and reference clarithromycin (CAS 81103-11-9) suspensions containing in 5 mL either 125 mg (study 1) or 250 mg (study 2) of the drug, administered as an oral dose of 10 mL...
Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet. [2004.04] This randomized, six-treatment, six-period, six sequence, single dose, crossover pharmacokinetic study assessed the effect of different types of food on the bioavailability of 500-mg cefaclor extended release tablet in 23 healthy male volunteers. A single dose of cefaclor extended release 500-mg tablet was administered at six occasions: after overnight fasting, after two vegetarian (high-fat and low-fat), two non-vegetarian (high-fat and low-fat) and rice diets...
Cefaclor AF vs Clarithromycin in acute exacerbation of chronic bronchitis (B3M-PK-AJBG). [2003.08] OBJECTIVE: To compare the efficacy and safety of Cefaclor AF vs Clarithromycin in the treatment of acute exacerbation of chronic bronchitis in adult subjects... CONCLUSIONS: The above results show that both Cefaclor AF and Clarithromycin are equally effective and safe in the treatment of acute exacerbation of chronic bronchitis in adult patients.
Clinical Trials Related to Ceclor (Cefaclor)
Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use [Recruiting]
This study is designed to look at healthcare utilization following the removal of tonsils
and adenoids in pediatric patients who are not given an antibiotic following surgery.
Patients Response to Early Switch To Oral:Osteomyelitis Study [Not yet recruiting]
Based on the current literature, investigators hypothesize that patients with osteomyelitis
who are treated with the standard approach of intravenous antibiotics for the full duration
of therapy will have the same clinical outcomes as patients treated with the experimental
approach of intravenous antibiotics with early switch to oral antibiotics.
The primary objective of this study is to compare patients with osteomyelitis treated with
the standard approach of intravenous antibiotics for the full duration of therapy versus
patients treated with intravenous antibiotics with an early switch to oral antibiotics in
relation to clinical outcomes at 12 months after discontinuation of antibiotic therapy.
Secondary objectives of the study include the evaluation of adverse events related to the
use of antibiotics as well as the cost of care evaluated from the hospital perspective.
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria [Completed]
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an
antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with
chronic bronchitis experiencing rapid onset of worsening of symptoms caused by bacteria.
Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder? [Recruiting]
During the laparoscopic cholecystectomy for acute cholecystitis, most surgeons routinely use
the postoperative antibiotics after surgery. However, there is no consensus regarding the
actual need of postoperative antibiotics in these cases and the use of postoperative
antibiotics remains controversial.
Investigators will compare the surgical outcomes after laparoscopic cholecystectomy to the
patients who has no evidence of systemic infection, according to the usage of postoperative
antibiotics or not. The investigators expect that the routine use of postoperative
antibiotics after laparoscopic cholecystectomy for acute cholecystitis gallbladder will have
no effects on the postoperative morbidity.
Use of Antibacterial Cement in Infected Dentin [Completed]
Dental materials with antibacterial properties can prevent the harmful effects caused by
oral cariogenic bacteria. This double-blind controlled clinical trial evaluated the
performance of antibacterial cement for sealing infected dentin in atraumatic restorations
of primary molars.
Reports of Suspected Ceclor (Cefaclor) Side Effects
Drug Hypersensitivity (13),
NO Adverse Event (4),
Erythema (1),
Loss of Consciousness (1),
Fibromyalgia (1),
Rash (1)
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Ceclor has an overall score of 1. The effectiveness score is 2 and the side effect score is 3. The scores are on ten point scale: 10 - best, 1 - worst.
| Ceclor review by care giver of 6 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | Ear infection |
Dosage & duration: | | I can't remember (dosage frequency: 2x/daily) for the period of 3 days |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | My son had an allergic reaction. He broke out in sever hives all over his body |
Side effects: | | Time - let them go away on their own |
Comments: | | n/a |
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| Ceclor review by 57 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | Extremely Severe Side Effects | | Treatment Info |
Condition / reason: | | upper respiratory infection on vacation |
Dosage & duration: | | 250 mg 3 x day taken 3 x for the period of 1 day |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | none - ended up in emergency room |
Side effects: | | Skin rash over entire body, delirium, incapacitating bone/muscle/joint pain, anaphylactic symptoms |
Comments: | | Went to urgent care while on vacation for upper respiratory infection. Was given Ceclor even though I am allergic to penicillin, but I was unfamiliar with drug and away from my regular pharmacist. Don't know if I felt better (cold/cough - wise) becasue my drug reaction was so severe I was in bed for days. |
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Page last updated: 2010-10-05
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