CAVERJECT SUMMARY
CAVERJECT contains alprostadil as the naturally occurring form of prostaglandin E1(PGE1).
CAVERJECT (CAVERJECT IMPULSE, CAVERJECT Sterile Powder, and CAVERJECT Injection) is indicated for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Intracavernosal CAVERJECT is also indicated as an adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.
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NEWS HIGHLIGHTS
Published Studies Related to Caverject (Alprostadil)
Long-term, multicenter study of the safety and efficacy of topical alprostadil cream in male patients with erectile dysfunction. [2009.02]
INTRODUCTION: Alprostadil is approved for treatment of male erectile dysfunction (ED) by injection or urethral insertion. Topical delivery of alprostadil offers an improved alternative. AIM: To evaluate the long-term safety and efficacy of topical alprostadil cream... CONCLUSIONS: Topical alprostadil cream was considered effective and safe by most patients and their partners, with most AEs limited to the application site. Dose adjustment to 300 mcg alprostadil facilitated the greatest improvement in erectile function in the majority of patients. A separate report will integrate patient data from the open-label extension and prior double-blind studies.
[Effects of alprostadil and ulinastatin on inflammatory response and lung injury after cardiopulmonary bypass in pediatric patients with congenital heart diseases] [2008.11.11]
OBJECTIVE: To investigate the therapeutic effects of alprostadil (Lipo-PGE1) and Ulinastatin on inflammatory response and lung injury after cardiopulmonary bypass (CPB) in pediatric patients with congenital heart diseases... CONCLUSION: Decreasing the inflammatory response after CPB, alprostadil and ulinastatin used during CPB effectively reduce the pulmonary injury via inhibition of the neutrophil activation and cytokines release.
Injection therapy for the treatment of erectile dysfunction: a comparison between alprostadil and a combination of vasoactive intestinal polypeptide and phentolamine mesilate. [2007.10]
OBJECTIVE: To compare two injectable treatments, alprostadil 5-20 microg powder for injection and a combination of vasoactive intestinal polypeptide (VIP) and phentolamine in patients with erectile dysfunction (ED)... CONCLUSIONS: VIP/phentolamine and alprostadil were effective treatments for ED, however the VIP/phentolamine combination was preferred by more patients, which may be because it was much less likely to cause pain.
Effects of pentoxifylline and alprostadil on ocular hemodynamics in healthy humans. [2007.02]
PURPOSE: Alprostadil, a prostaglandin (PG)E(1) analogue and pentoxifylline, an alkylxanthine derivate, have been shown to exert vasodilatory effects in several vascular beds. The purpose of the present study was to investigate the effect of PGE(1) and pentoxifylline on the ocular circulation... CONCLUSIONS: PGE(1) did not alter the parameters of retinal or choroidal circulation in healthy subjects. Pentoxifylline increased FPA, but did not change choroidal blood flow as measured with laser Doppler flowmetry and did not affect retinal blood flow parameters. Accordingly, neither pentoxifylline nor PGE(1) appears to be suitable to improve ocular blood flow in healthy subjects. Whether long-term treatment with alprostadil would improve choroidal blood flow in patients with vascular disease remains to be established.
[Intraurethrally applicated alprostadil for the treatment of organic erectile dysfunction in practice: a multicenter clinical monitoring study (noninterventional investigation)] [2007]
In a multicenter clinical monitoring study (observation of use investigation according to 67.6 of the German Drug Law), which was conducted between 2003 and 2005 in 105 urological practices in 314 patients with organic erectile dysfunction (ED), efficacy, safety, convenience and acceptance of intraurethral administered alprostadil (CAS 745-65-3; MUSE - Medicated Urethral System for Erection) was studied...
Clinical Trials Related to Caverject (Alprostadil)
The Use of Prostaglandin E1 in Head and Neck Microsurgery [Recruiting]
Prostaglandin E1 (PGE1 )has been shown to have vasodilatation and anti-thrombosis effects,
so it is used by some surgeons after microsurgery to keep the patency of the anastomosed
small vessels. However, PGE 1 may also causes some complications, like pleural effusion or
deep vein thrombosis. Therefore, it remains uncertain whether a routine use of PGE 1 after
head and neck microsurgery is justified. We aim to test the hypothesis that PGE 1 increases
postoperative vessel patency rate in patients undergoing head and neck microsurgery, with a
comparable complication rate as the control group.
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure [Recruiting]
This pilot study is a randomized, placebo-controlled, clinical trial to test the safety of
using the intravenous form of Prostaglandin E1 (PGE1) in an inhaled form for treatment of
hypoxemic respiratory failure in term newborns. The study will enroll 50 infants diagnosed
with hypoxemic respiratory failure at nine NICHD Neonatal Research Network sites, and
randomly assign them to receive one dose over a 72-hour period of either high concentration
PGE1 (300 ng/kg/min), low concentration PGE1 (150 ng/kg/min), or placebo (normal saline, the
diluent for the drug). In addition to determining the safety, optimal dose, and duration of
the therapy, this pilot trial will evaluate the feasibility of conducting a larger,
multi-center randomized, blinded placebo-controlled trial.
Alprostadil in Macular Degeneration Study (AIMS) [Recruiting]
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV [Recruiting]
The study is to confirmedly show a superior effect of Alprostadil compared to placebo on the
rate of complete healing of ischemic necroses and ulcerations.
Prostaglandin E1 (Liprostin) Treatment With Lower Limb Angioplasty for Peripheral Arterial Occlusive Disease [Recruiting]
This is the first clinical research trial in which intravenous Prostaglandin E1 (PGE1 is a
vasoactive hormone) will be used as supportive treatment along with the angioplasty
procedure to treat or open up a blocked artery within one lower limb or the most affected of
two limbs in subjects with Peripheral Arterial Occlusive Disease.
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Page last updated: 2009-10-20
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