DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Catapres (Clonidine Hydrochloride) - Summary

 
 



CATAPRES SUMMARY

Catapres®
(clonidine hydrochloride USP)

CATAPRES® (clonidine hydrochloride USP) is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.

CATAPRES® (clonidine hydrochloride USP) is indicated in the treatment of hypertension. CATAPRES may be employed alone or concomitantly with other antihypertensive agents.


See all Catapres indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Catapres (Clonidine)

ACC: Aspirin, Clonidine Don't Cut Postop MIs (CME/CE)
Source: MedPage Today Surgery [2014.03.31]
WASHINGTON (MedPage Today) -- The search must continue for a therapy that will lessen the risk of myocardial infarction following noncardiac surgery, following disappointing results from a large randomized trial.

more news >>

Published Studies Related to Catapres (Clonidine)

Clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts. [2012]
BACKGROUND: Impulsivity refers to a wide spectrum of actions characterized by quick and nonplanned reactions to external and internal stimuli, without taking into account the possible negative consequences for the individual or others, and decision-making is one of the biologically dissociated impulsive behaviors...

The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal. [2012]
BACKGROUND: The management of withdrawal absorbs substantial clinical efforts in opioid dependence (OD)... CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Preliminary results elucidate neurobiological mechanisms of OD and support the utility of controlled studies on a novel VLNTX + low-dose clonidine combination for the management of opioid withdrawal.

Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial. [2011.10.10]
PURPOSE: Therapies for breast cancer may induce hot flashes that can affect quality of life. We undertook a double-blind, placebo-controlled trial with the primary objective of comparing the average daily hot flash scores in the twelfth week among patients treated with venlafaxine, clonidine, and placebo. Additional analyses of the hot flash score over the full 12 weeks of treatment were performed... CONCLUSION: Venlafaxine and clonidine are effective treatments in the management of hot flashes in patients with breast cancer. Venlafaxine resulted in a more immediate reduction of hot flash scores when compared with clonidine; however, hot flash scores at week 12 were lower in the clonidine group than in the venlafaxine group.

Addition of clonidine to a continuous patient-controlled epidural infusion of low-concentration levobupivacaine plus sufentanil in primiparous women during labour. [2011.09]
We studied the potentiation of analgesia for labour by the addition of clonidine to epidural low-concentration levobupivacaine with sufentanil in a randomised, double-blinded study. We enrolled primiparous women who were in spontaneous labour...

Supplementation of retrobulbar block with clonidine in vitreoretinal surgery: effect on postoperative pain. [2011.08]
STUDY OBJECTIVE: To evaluate the effect of clonidine when added to local anesthetics on duration of postoperative analgesia during retrobulbar block... CONCLUSIONS: The addition of clonidine 0.5 mug/kg to the local anesthetics of a retrobulbar block for vitreoretinal surgery decreases the frequency of postoperative pain and prolongs the time of analgesia. Copyright (c) 2011 Elsevier Inc. All rights reserved.

more studies >>

Clinical Trials Related to Catapres (Clonidine)

Use of Transdermal Clonidine in Trauma Patients [Recruiting]
This study will attempt to learn how to better treat trauma patients with delirium who are on a breathing machine. Delirium, also known as acute, temporary brain dysfunction, is a common reason why ventilated patients can not be weaned from the breathing machine even though their lungs may be healthy enough to breathe without the machine. The study hopes to show that by decreasing the patient's delirium it will lead to quicker weaning from the breathing machine and possibly a quicker overall recovery as well. Patients enrolled in this study will be treated with Clonidine or placebo. Clonidine is a drug that produces significant calming effects, decreases anxiety, and reduces pain, but with a lower incidence of delirium than other medications used in the ICU for this purpose. Clonidine is not approved by the Federal Food and Drug Administration for treatment of delirium, but is commonly used for this purpose.

Epidural Fentanyl-bupivacaine Versus Clonidine-bupivacaine for Breakthrough Pain in Advanced Labor [Not yet recruiting]
Epidural analgesia is widely regarding as the most effective analgesic strategy for labor pain. Modern practice is to utilize dilute local anesthetics as a continuous infusion along with an opioid, e. g., our common "recipe" of 12 ml/hr of 0. 0625% bupivacaine with 2 micrograms/ml fentanyl, after the initial dose to maintain patient comfort until delivery. This dose of the infusion often provides adequate comfort without interfering with the mobility of the patient and her ability to effectively push during delivery. However, this low dose epidural infusion strategy often results in recurrence of pain after an initial pain free period.

This breakthrough pain is treated by administering small boluses of analgesics via the epidural catheter. The pain occurring in labor is initially of visceral origin and is mediated by pain fibers originating from the low thoracic and upper lumbar segments of the spinal cord. As labor progresses to the late first phase (also known as transitional stage), pain sensations originating from the distension of the pelvic floor, vagina and perineum adds a somatic component to labor pain. This type of breakthrough pain is often difficult to treat.

Although requests from patients to alleviate late stage breakthrough pain are common, no one knows the most effective strategy for pain management in this stage of labor. This study is designed to compare the efficacy of two treatments for controlling late first stage breakthrough pain during labor with an epidural infusion in place: clonidine-bupivacaine versus fentanyl-bupivacaine.

Women who have labor epidural analgesia in place will be enrolled to be randomized if and when they present with breakthrough pain in the late first stage or second stage of labor (≥ 8 cm dilated). They will receive 8 ml of a solution containing 10 mg bupivacaine and 75 micrograms of either fentanyl (an opioid or "narcotic") or clonidine (an "alpha-2 agonist known to be effective as an epidural analgesic).

Pain relief, labor progress and outcome will be assessed to compare fentanyl versus clonidine.

It is the hypothesis of this study that clonidine added to bupivacaine is a better analgesic than fentanyl added to bupivacaine for breakthrough pain in advanced labor.

The Use of Clonidine in Pain and Anxiety Associated With Acute Burn Injury in Children [Recruiting]
Some of the children who suffer acute burn injury do not have adequate pain and anxiety management with the current regimen of scheduled opiates (morphine) and benzodiazepines (lorazepam). Other children have significant side effects or contraindications, such as constipation or over sedation, when taking these medications. Clonidine is known to reduce the need for morphine in the management of postoperative pain. The addition of clonidine to the pharmacological treatment of burn wound pain offers a possible adjunct to the standard opiate and benzodiazepines regimen. Clonidine has been used in children in both on a short-term basis (such as postoperative pain management) and on a long-term basis (such as the treatment of attention deficit hyperactivity disorder (ADHD)). This study tests the hypothesis that clonidine in a dose of 5 ug/kilo every 8 hours will be a useful adjunct to the management of pain and anxiety in the acutely burned child. All children will be treated by protocol with morphine (0. 03mg/kilo) q4hr prn pain and lorazepam (0. 03 mg/kilo) q 4 hours prn anxiety. In addition, after informed consent is obtained the children will be randomized to the addition clonidine or placebo. Pain and anxiety will be assessed using standard instruments blind to the medication being used on a daily basis Also the total dose of morphine and lorazepam during the 10 days of added clonidine or placebo will be recorded.. The pain rating, anxiety ratings, total morphine dose, and total lorazepam dose will be compared between the placebo and clonidine groups with a Student's t test. Once the blind is broken the child will be allowed to remain on the clonidine if it is beneficial. The second year of the grant will expand the age groups down to younger children and also begin to gain information about the effect of clonidine on the hypermetabolic state secondary to burn injury.

PeriOperative ISchemic Evaluation-2 Trial [Recruiting]
Major surgeries not involving the heart are common, and major heart problems during or after such surgeries represent a large population health problem. Few treatments to prevent heart problems around the time of surgery have been tested. There is encouraging data suggesting that small doses of Acetyl-Salicylic Acid (ASA) and Clonidine, which are two medications, given individually for a short period before and after major surgeries may prevent major heart problems. The POISE-2 Trial is a large international study to test if ASA and Clonidine can prevent heart attacks and deaths from heart problems around the time of surgery.

Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients [Recruiting]
Hot flashes present a considerable problem for many breast cancer patients; these symptoms may be intensified by hormonal therapies, such as aromatase inhibitors. This study examines the value of solifenacin (a muscarinic acetylcholine receptor antagonist) in reducing hot flashes, compared with clonidine (a medication often used for treating hot flashes).

more trials >>

Reports of Suspected Catapres (Clonidine) Side Effects

Hypertension (8)Weight Decreased (7)Hair Texture Abnormal (7)DRY Mouth (7)Decreased Appetite (7)Hypotension (7)Anxiety (7)Drug Ineffective (6)Headache (6)Blood Pressure Increased (6)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Catapres has an overall score of 6.75. The effectiveness score is 5.50 and the side effect score is 8.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Catapres review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   one tab twice daily taken twice daily for the period of since 2007 to current
Other conditions:   hot flashes
Other drugs taken:   lisinopril/hctz 20-12.5 tab
  
Reported Results
Benefits:   (clonidine)It assisted in lowering my blood pressure by causing me to have a more voluminous (not more frequent)urination,when urged.Also,it aided in- depressing my agonizing hot flashes.They came at sequential intervals at time of menses and would last in that manner until completion of menses.Thereafter,they were intermitten daily.
Side effects:   If this is the side effect.It would be, soon after taking the meds,There is a timed-released drowsy effect that occurs,within a matter of 15-20 minutes.This is the only so-called side effect that I've experienced.But,I guess,it is a matter of where you are and what's on your agenda during this side-effect.
Comments:   I'm not completely sure what to write here,that would consist of fifty words.I take (Clonidine)-0.1mg 1 tab twice daily and (Lisinopril/HCTZ)-20mgs.12.5 1tab,twice daily.I've learned to take them with food.Earlier,when introduced to these meds,upon attending a Drs. appointment and having my blood pressure checked,the reading would be high and I felt no internal or external symptoms.The inquiry would be have you taken your meds? and I had.So,it was suggested that I try administering them with food.Thereafter,no more high readings and entered a normalized phase.

 

Catapres review by 59 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Hot Flashes
Dosage & duration:   0.1 mg taken 1x a day at bedtime for the period of Once
Other conditions:   Hypothyroidism
Other drugs taken:   Synthroid
  
Reported Results
Benefits:   It was supposed to stop the hot flashes that were keeping me awake at night.
Side effects:   Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes.
Comments:   I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine

 

Catapres review by 59 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Hot Flashes
Dosage & duration:   0.1 mg taken 1x a day at bedtime for the period of Once
Other conditions:   Hypothyroidism
Other drugs taken:   Synthroid
  
Reported Results
Benefits:   It was supposed to stop the hot flashes that were keeping me awake at night.
Side effects:   Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes.
Comments:   I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine

See all Catapres reviews / ratings >>

Page last updated: 2014-03-31

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2012