CATAPRES SUMMARY
Catapres®
(clonidine hydrochloride USP)
CATAPRES® (clonidine hydrochloride USP) is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.
CATAPRES® (clonidine hydrochloride USP) is indicated in the treatment of hypertension. CATAPRES may be employed alone or concomitantly with other antihypertensive agents.
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NEWS HIGHLIGHTSMedia Articles Related to Catapres (Clonidine)
Addrenex Pharmaceuticals Files SNDA Submission For Clonicel To Treat ADHD
Source: ADHD News From Medical News Today [2009.10.04]
Addrenex Pharmaceuticals and Sciele Pharma, Inc., a Shionogi company announced that Addrenex has submitted a supplemental New Drug Application (sNDA) to the United States Food and Drug Administration (FDA) for Clonicel (modified-release clonidine) to treat attention deficit hyperactivity disorder (ADHD). The submission is based on the successful completion of Phase III clinical trials demonstrating statistical significance when Clonicel was used to treat ADHD in children and adolescents.
Published Studies Related to Catapres (Clonidine)
Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. [2009.08]
BACKGROUND: Caudal block is a common technique for paediatric analgesia but with the disadvantage of short duration of action after single injection. Caudal dexmedetomidine and clonidine could offer significant analgesic benefits. We compared the analgesic effects and side-effects of dexmedetomidine and clonidine added to bupivacaine in paediatric patients undergoing lower abdominal surgeries... CONCLUSIONS: Addition of dexmedetomidine or clonidine to caudal bupivacaine significantly promoted analgesia in children undergoing lower abdominal surgeries with no significant advantage of dexmedetomidine over clonidine and without an increase in incidence of side-effects.
[Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children] [2009.07]
OBJECTIVE: Children with Tourette's syndrome (TS) have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children... CONCLUSIONS: Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.
Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not. [2009.07]
BACKGROUND: Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia. However, nefopam alone is insufficient; it will thus need to be combined with another drug. Clonidine and alfentanil each reduce the shivering threshold. This study, therefore, tested the hypothesis that nefopam, combined either with clonidine or alfentanil, synergistically reduces the shivering threshold... CONCLUSIONS: Nefopam and alfentanil additively reduce the shivering threshold, but nefopam and clonidine do not.
Effects of epidural clonidine and neostigmine following intrathecal labour analgesia: a randomised, double-blind, placebo-controlled trial. [2009.07]
BACKGROUND: The limited duration of spinal labour analgesia combined with problems associated with maintenance of epidural analgesia, have prompted the search for combinations that could prolong spinal analgesia. A randomised, double-blind trial was carried out to test the hypotheses (a) that initial spinal labour analgesia is prolonged by administering clonidine and neostigmine epidurally whilst (b) the hourly local anaesthetic consumption is reduced... CONCLUSION: Epidural administration of neostigmine 500 microg and clonidine 75 microg, following the intrathecal injection of ropivacaine and sufentanil, prolongs analgesia and reduces hourly ropivacaine consumption.
Unilateral spinal anaesthesia for outpatient surgery: a comparison between hyperbaric bupivacaine and bupivacaine-clonidine combination. [2009.07]
BACKGROUND: Low-dose hyperbaric bupivacaine has been used to produce unilateral spinal anaesthesia for outpatient surgery. Unilateral spinal anaesthesia is associated with reduction of hypotension, faster recovery and increased patient satisfaction.
Clinical Trials Related to Catapres (Clonidine)
Clonidine Versus Midazolam for Premedication [Completed]
alpha2-agonists like clonidine offer several useful effects that make these drugs an
interesting alternative to benzodiazepines for pharmacological premedication. We therefore
sought to determine the effect of pre-anesthetic medication with clonidine vs. midazolam in a
randomized, double-blind, placebo controlled study. Effects of pre-anesthetic medication were
assessed on (1) bispectral index (BIS),(2) sedation score and visual analog scales for
anxiety and pain, (3) neuropsychologic tests to assess cognitive function and (4) circulating
stress hormones.
Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome [Completed]
To test the hypothesis that the combination of the tincture of opium (DTO) and clonidine will
be more effective in treating infants with neonatal abstinence syndrome (opioid withdrawal)
than tincture of opium (DTO) alone.
Clonidine Versus Adenosine to Treat Neuropathic Pain [Active, not recruiting]
Clonidine in Attention Deficit Hyperactivity Disorder (ADHD) in Children [Completed]
The purpose of this study is to determine the safety and efficacy of clonidine alone or in
combination with methylphenidate for children 7-12 years of age with attention-deficit,
hyperactivity disorder.
Study Evaluating the Safety and Efficacy of CLONICEL® to Treat Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD) [Active, not recruiting]
The purpose of this study is to determine whether CLONICEL® (clonidine HCl sustained release)
is a safe and effective treatment for children and adolescents with attention deficit
hyperactivity disorder (ADHD).
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Catapres has an overall score of 5.67. The effectiveness score is 4 and the side effect score is 8.67. The scores are on ten point scale: 10 - best, 1 - worst.
| | Catapres review by 45 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | High Blood pressure |
| Dosage & duration: | | Catapres 150 ug; betaloc 47.5mg taken daily for the period of have been taking approximately 2 years |
| Other conditions: | | Rosacea |
| Other drugs taken: | | Betaloc (Metoprolol) | | |
Reported Results |
| Benefits: | | Catapres was initially effective at reducing my blood pressure on it's own, but there was reduced effectiveness over time. For this reason I began taking Betaloc in addition to catapres (daily). Taking these two drugs together has resulted in good blood pressure control with a fairly low dose of each drug.
A side benefit of taking catapres has been that it helps to control my Rosacea symptoms. I have had the reason for this explained to me, but cannot recal the details (has something to do with Catapres effect on the sympathetic nervous system). |
| Side effects: | | I experience slight sedation after taking Catapres which is helpful for me as a light sleeper. I believe I experience some slight lethargy that is ongoing, but not troublesome. When I first started taking Catapres I got a very dry mouth, but this quickly went away. I have experienced no other side effects that I am aware of. |
| Comments: | | I'm not sure what this question means, and may have already answered it. I am taking Catapres and Betaloc for longstanding essential hypertension. I have noticed that when I take these two drugs together their individual effectiveness is amplified. I have been cautioned by my doctor that it is important not to suddenly stop taking this drug combination as this could cause a heart attack. |
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| | Catapres review by 59 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Hot Flashes |
| Dosage & duration: | | 0.1 mg taken 1x a day at bedtime for the period of Once |
| Other conditions: | | Hypothyroidism |
| Other drugs taken: | | Synthroid | | |
Reported Results |
| Benefits: | | It was supposed to stop the hot flashes that were keeping me awake at night. |
| Side effects: | | Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes. |
| Comments: | | I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine |
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| | Catapres review by 59 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Hot Flashes |
| Dosage & duration: | | 0.1 mg taken 1x a day at bedtime for the period of Once |
| Other conditions: | | Hypothyroidism |
| Other drugs taken: | | Synthroid | | |
Reported Results |
| Benefits: | | It was supposed to stop the hot flashes that were keeping me awake at night. |
| Side effects: | | Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes. |
| Comments: | | I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine |
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Page last updated: 2009-10-20
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