DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Carteolol (Carteolol Hydrochloride Ophthalmic) - Description and Clinical Pharmacology

 
 



Rx only

FOR USE IN THE EYES ONLY

DESCRIPTION

Carteolol Hydrochloride Ophthalmic Solution USP, 1%, is a nonselective beta-adrenoceptor blocking agent for ophthalmic use. Carteolol hydrochloride is represented by the following structural formula:

                                                      C16H24N2O3•HCl                                       Mol. Wt. 328.84

Chemical Name: (±)-5-[3-[(1, 1-dimethylethyl) amino]-2-hydroxypropoxy]-3, 4-dihydro-2(1 H)-quinolinone monohydrochloride.

Each mL of sterile solution contains:

ACTIVE: Carteolol Hydrochloride 10 mg (1%), INACTIVES: Sodium Chloride, Monobasic and Dibasic Sodium Phosphate, Purified Water. PRESERVATIVE ADDED: Benzalkonium Chloride 0.005%. The product has a pH range of 6.2 - 7.2.

CLINICAL PHARMACOLOGY

Carteolol is a nonselective beta-adrenergic blocking agent with associated intrinsic sympathomimetic activity and without significant membrane-stabilizing activity.

Carteolol hydrochloride reduces normal and elevated intraocular pressure (lOP) whether or not accompanied by glaucoma. The exact mechanism of the ocular hypotensive effect of beta-blockers has not been definitely demonstrated.

In general, beta-adrenergic blockers reduce cardiac output in patients in good and poor cardiovascular health. In patients with severe impairment of myocardial function, beta-blockers may inhibit the sympathetic stimulation necessary to maintain adequate cardiac function. Beta-adrenergic blockers may also increase airway resistance in the bronchi and bronchioles due to unopposed parasympathetic activity.

Given topically twice daily in controlled domestic clinical trials ranging from 1.5 to 3 months, carteolol hydrochloride ophthalmic solution USP, 1% produced a median percent reduction of IOP 22% to 25%. No significant effects were noted on corneal sensitivity, tear secretion, or pupil size.

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017