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Cardura (Doxazosin Mesylate) - Summary

 
 



CARDURA SUMMARY

CARDURA® (doxazosin mesylate) is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors.

CARDURA® (doxazosin mesylate) is indicated for the following:

A. Benign Prostatic Hyperplasia (BPH)

CARDURA is indicated for the treatment of both the urinary outflow obstruction and obstructive and irritative symptoms associated with BPH: obstructive symptoms (hesitation, intermittency, dribbling, weak urinary stream, incomplete emptying of the bladder) and irritative symptoms (nocturia, daytime frequency, urgency, burning). CARDURA may be used in all BPH patients whether hypertensive or normotensive. In patients with hypertension and BPH, both conditions were effectively treated with CARDURA monotherapy. CARDURA provides rapid improvement in symptoms and urinary flow rate in 66–71% of patients. Sustained improvements with CARDURA were seen in patients treated for up to 14 weeks in double blind studies and up to 2 years in open-label studies.

B. Hypertension

CARDURA (doxazosin mesylate) is also indicated for the treatment of hypertension. CARDURA may be used alone or in combination with diuretics, beta-adrenergic blocking agents, calcium channel blockers or angiotensin-converting enzyme inhibitors.


See all Cardura indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Cardura (Doxazosin)

Long-term effects of doxazosin, finasteride, and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score [IPSS]-QoL) over 4 years... CONCLUSIONS: QoL of men treated with doxazosin, finasteride, and

Effect of doxazosin gastrointestinal therapeutic system 4 mg vs tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms: a prospective, multicenter, randomized, open, parallel study. [2011.09]
OBJECTIVE: To compare the efficacy of the doxazosin gastrointestinal therapeutic system (doxazosin-GITS) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)... CONCLUSION: In Chinese patients with LUTS/BPH, doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Tamsulosin and doxazosin as adjunctive therapy following shock-wave lithotripsy of renal calculi: randomized controlled trial. [2011.08.12]
Alpha-blockers have been established as medical expulsive therapy for urolithiasis. We aimed to assess the effect of tamsulosin and doxazosin as adjunctive therapy following SWL for renal calculi... The side-effects of these agents are common and should be weighted against the benefits of their usage.

An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia. [2011.07]
This study sought to investigate the clinical efficacy and safety of combined oral therapy with sildenafil and doxazosin GITS compared to sildenafil monotherapy in treating Chinese patients with erectile dysfunction (ED) and lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH/LUTS)...

[Kidney-tonifying and dampness-expelling Chinese herbal medicine combined with doxazosin for the treatment of chronic epididymitis]. [2010.12]
OBJECTIVE: To study the clinical effects of kidney-tonifying and dampness-expelling Chinese herbal medicine combined with doxazosin in the treatment of chronic epididymitis... CONCLUSION: Either doxazosin alone or kidney-tonifying and dampness-expelling Chinese herbal decoction combined with doxazosin is obviously effective on chronic epididymitis, but the combined medication produces an even better efficacy.

more studies >>

Clinical Trials Related to Cardura (Doxazosin)

The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine [Recruiting]
Human Laboratory Trial of Doxazosin for Cocaine Dependence: Accumulating evidence implicates noradrenergic (NE) systems in mediating the effects of stimulants (1-8). Mice lacking NE £\

- 1 receptor mice show reduced sensitivity to cocaine and amphetamine (8, 9). Local depletion

of prefrontal cortex (PFC) NE reduced rewarding effects of amphetamine and reduced amphetamine-induced dopamine (DA) release in the PFC and accumbens (7), suggesting that PFC NE contributes to the rewarding effects of stimulants. Treatment with the NE Æ’Ă‘-1 antagonist prazosin has been shown to antagonize a variety of effects produced by cocaine and amphetamine. In rats, prazosin (1-2 mg/kg) significantly attenuated the locomotor activating effects produced by cocaine (10-12) and for amphetamine (4, 13, 14). Similar findings have been observed for the discriminative stimulus effects produced by cocaine and amphetamine in mice (15) and for food-maintained responding in pigeons (16). More recently, prazosin (0. 3 mg/kg) reduced reinstatement of extinguished cocaine-seeking behavior in rats without affecting responding for food, suggesting that prazosin my blunt the motivational effects of drug cues (5). Clinical Experience with Alpha-1 Adrenergic Antagonists: Prazosin is a prototypical antagonist at NE Ă‚Â£\-1 receptors. When first released the medication was thought to produce relaxation of smooth muscles in the vasculature. Since then however it has been determined that prazosin antagonizes norepinephrine and this mediates the antihypertensive effect (17). The medication has been assessed extensively for the treatment of hypertension (18). The initial dose is 1mg two or three times per day. The usual dose range is 6mg/day to 15mg/day, with some patients requiring up to 40mg/day in divided doses. The most common side effects are: dizziness 10. 3%, headache 7. 8%, drowsiness 7. 6%, lack of energy 6. 9%, weakness 6. 5%, palpitations 5. 3%, and nausea 4. 9%. In most instances side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug. More recently, prazosin has been successfully used to treat post traumatic stress disorder (19, 20). For this indication, prazosin was initiated at 1mg at bedtime and increased as needed to control symptoms to up to 15mg at bedtime by day 28. This approach resulted in no change in systolic and diastolic blood pressure compared to pretreatment measurements. Several subjects reported transient dizziness upon standing (9/14 in the prazosin group and 6/15 in the placebo group), but none reported syncope. Prazosin has a relatively short elimination half-life of 3. 5 h (21). Longer-lasting cogeners (e. g. terazosin and doxazosin) are available, but there is no experience using these medications as treatments for cocaine dependence. The purpose of this study is to evaluate the effects of doxazosin on the cardiovascular and subjective effects of cocaine in a human laboratory study. Doxazosin was selected because it has a longer elimination half-life (22h) compared to terazosin (12h). The side-effect profile of doxazosin closely resembles that of prazosin.

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) [Recruiting]
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). The investigators hypothesize that doxazosin will attenuate the cardiovascular and subjective response to MDMA.

The Efficacy of Doxazosin for Cocaine Users [Recruiting]
Doxazosin, an alpha 1-adrenergic receptor may play an important role in cocaine addiction in human. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine addicts.

Phenoxybenzamine Versus Doxazosin in PCC Patients [Recruiting]

- Rationale: The optimal preoperative medical management for patients with a

pheochromocytoma is currently unknown. In particular, there is no agreement with respect to whether phenoxybenzamine or doxazosin is the optimal alfa-adrenoreceptor antagonist to be administered before surgical resection of a pheochromocytoma. We hypothesized that the competitive alfa1-antagonist doxazosin is superior to the non-competitive alfa1- and alfa2-antagonist phenoxybenzamine.

- Objective: comparing effects of preoperative treatment with either phenoxybenzamine or

doxazosin on intraoperative hemodynamic control in patients undergoing surgical resection of a pheochromocytoma.

- Study design: Randomised controlled open-label trial.

- Study population: 18 - 55 yr old. Adult patients with a recently diagnosed benign

pheochromocytoma.

- Intervention: Patients are randomised to receive oral treatment with either

phenoxybenzamine or doxazosin preoperatively.

- Main study parameters/endpoints: The main study parameter is defined as the frequency

of intraoperative blood pressure episodes outside the predefined target range after pretreatment with either phenoxybenzamine or doxazosin.

In this multicenter trial, we compare the effects of two commonly used drugs in patients being medically prepared for resection of a benign pheochromocytoma. Participants are not subjected to an experimental treatment of any kind, as we merely aim to describe in detail the perioperative course in general and, in particular, the intraoperative hemodynamic control in patients treated preoperatively with either phenoxybenzamine or doxazosin. A routine diagnostic work-up for pheochromocytoma will be performed in all participants. One extra blood sample (volume: 48,5 mL) is drawn before start of the study medication, and participants need to record their symptoms in a diary. In addition, patients who are pretreated in the outpatient clinic monitor their blood pressure and pulse rate at home with an automated device. Treatment with an alfa-adrenoreceptor antagonist is initiated at least

2 - 3 weeks prior to surgery. Patients who are admitted to the hospital for pretreatment

with an alfa-adrenoreceptor antagonist have their blood pressure and pulse rate measured by the nursing staff. The final site visit is planned at 30 days after surgery, in line with current practice.

Pharmacogenetics of Doxazosin for Cocaine Dependence [Recruiting]
Doxazosin, an alpha 1-adrenergic receptor antagonist, may play an important role in cocaine addiction in humans. This study will evaluate to what extent the prospective screening for catecholamine related polymorphisms for alpha 1 NE receptor/transporter, COMT and DBH as main targets predict the treatment efficacy of doxazosin for cocaine-using behavior.

more trials >>

Reports of Suspected Cardura (Doxazosin) Side Effects

Syncope (14)Blood Pressure Increased (11)Hypotension (10)Dyspnoea (9)Drug Ineffective (8)Headache (8)Cerebrovascular Accident (7)Prostatic Disorder (7)Anxiety (7)Hypertension (7)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Cardura has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Cardura review by 49 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Problems with my prostate
Dosage & duration:   2mg taken daily for the period of 45 days
Other conditions:   none
Other drugs taken:   Prevacid
  
Reported Results
Benefits:   Reduced prostate pain.
Side effects:   None that I am aware of.
Comments:   I took this medication to reduce pain I was experiencing with my prostate. It took about two to three weeks after which the pain was significantly reduced. I was also experiencing a sense of tightness in this area that it eliminated.

See all Cardura reviews / ratings >>

Page last updated: 2013-02-10

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