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Cardura XL (Doxazosin Mesylate) - Summary

 
 



CARDURA XL SUMMARY

CARDURA® XL
(doxazosin mesylate extended release tablets)

CARDURA XL (doxazosin mesylate extended release tablets) contains doxazosin mesylate which is a quinazoline compound with the chemical name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate.

CARDURA XL is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

CARDURA XL is not indicated for the treatment of hypertension.


See all Cardura XL indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Cardura XL (Doxazosin)

Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Source: MedicineNet Prostatitis Specialty [2012.02.29]
Title: Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Category: MedicineNet Quiz
Created: 2/7/2012 3:29:00 PM
Last Editorial Review: 2/29/2012 6:25:09 PM

Benign Prostatic Hyperplasia
Source: MedicineNet Saw Palmetto Specialty [2008.06.23]
Title: Benign Prostatic Hyperplasia
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 6/23/2008

more news >>

Published Studies Related to Cardura XL (Doxazosin)

Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy. [2014]
Inventory during 4 years... CONCLUSIONS: This study significantly extends understanding of the effects of

Long-term effects of doxazosin, finasteride, and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score [IPSS]-QoL) over 4 years... CONCLUSIONS: QoL of men treated with doxazosin, finasteride, and

Long-term effects of doxazosin, finasteride and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score-QoL) during 4 years... CONCLUSIONS: The quality of life of men treated with doxazosin, finasteride, and

Effect of doxazosin gastrointestinal therapeutic system 4 mg vs tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms: a prospective, multicenter, randomized, open, parallel study. [2011.09]
OBJECTIVE: To compare the efficacy of the doxazosin gastrointestinal therapeutic system (doxazosin-GITS) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)... CONCLUSION: In Chinese patients with LUTS/BPH, doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Tamsulosin and doxazosin as adjunctive therapy following shock-wave lithotripsy of renal calculi: randomized controlled trial. [2011.08.12]
Alpha-blockers have been established as medical expulsive therapy for urolithiasis. We aimed to assess the effect of tamsulosin and doxazosin as adjunctive therapy following SWL for renal calculi... The side-effects of these agents are common and should be weighted against the benefits of their usage.

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Clinical Trials Related to Cardura XL (Doxazosin)

The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine [Recruiting]
Human Laboratory Trial of Doxazosin for Cocaine Dependence: Accumulating evidence implicates noradrenergic (NE) systems in mediating the effects of stimulants (1-8). Mice lacking NE £\

- 1 receptor mice show reduced sensitivity to cocaine and amphetamine (8, 9). Local depletion

of prefrontal cortex (PFC) NE reduced rewarding effects of amphetamine and reduced amphetamine-induced dopamine (DA) release in the PFC and accumbens (7), suggesting that PFC NE contributes to the rewarding effects of stimulants. Treatment with the NE ƒÑ-1 antagonist prazosin has been shown to antagonize a variety of effects produced by cocaine and amphetamine. In rats, prazosin (1-2 mg/kg) significantly attenuated the locomotor activating effects produced by cocaine (10-12) and for amphetamine (4, 13, 14). Similar findings have been observed for the discriminative stimulus effects produced by cocaine and amphetamine in mice (15) and for food-maintained responding in pigeons (16). More recently, prazosin (0. 3 mg/kg) reduced reinstatement of extinguished cocaine-seeking behavior in rats without affecting responding for food, suggesting that prazosin my blunt the motivational effects of drug cues (5). Clinical Experience with Alpha-1 Adrenergic Antagonists: Prazosin is a prototypical antagonist at NE £\-1 receptors. When first released the medication was thought to produce relaxation of smooth muscles in the vasculature. Since then however it has been determined that prazosin antagonizes norepinephrine and this mediates the antihypertensive effect (17). The medication has been assessed extensively for the treatment of hypertension (18). The initial dose is 1mg two or three times per day. The usual dose range is 6mg/day to 15mg/day, with some patients requiring up to 40mg/day in divided doses. The most common side effects are: dizziness 10. 3%, headache 7. 8%, drowsiness 7. 6%, lack of energy 6. 9%, weakness 6. 5%, palpitations 5. 3%, and nausea 4. 9%. In most instances side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug. More recently, prazosin has been successfully used to treat post traumatic stress disorder (19, 20). For this indication, prazosin was initiated at 1mg at bedtime and increased as needed to control symptoms to up to 15mg at bedtime by day 28. This approach resulted in no change in systolic and diastolic blood pressure compared to pretreatment measurements. Several subjects reported transient dizziness upon standing (9/14 in the prazosin group and 6/15 in the placebo group), but none reported syncope. Prazosin has a relatively short elimination half-life of 3. 5 h (21). Longer-lasting cogeners (e. g. terazosin and doxazosin) are available, but there is no experience using these medications as treatments for cocaine dependence. The purpose of this study is to evaluate the effects of doxazosin on the cardiovascular and subjective effects of cocaine in a human laboratory study. Doxazosin was selected because it has a longer elimination half-life (22h) compared to terazosin (12h). The side-effect profile of doxazosin closely resembles that of prazosin.

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) [Recruiting]
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). The investigators hypothesize that doxazosin will attenuate the cardiovascular and subjective response to MDMA.

The Efficacy of Doxazosin for Cocaine Users [Recruiting]
Doxazosin, an alpha 1-adrenergic receptor may play an important role in cocaine addiction in human. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine addicts.

Doxazosin for Psychostimulant Dependence [Recruiting]
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder. Thus, the investigators wish to study whether a blood pressure drug thought to reduce drug craving through its interaction at

particular adrenergic receptors - doxazosin - can delay relapse relative to placebo in

psychostimulant dependent participants who attain 2 weeks of abstinence. Our hypothesis is that doxazosin will prolong abstinence relative to placebo in psychostimulant dependent participants.

Effects Of Doxazosin Gastrointestinal Therapeutic System On Ambulatory Blood Pressure And Cardiovascular Risk Factors In Uncontrolled Hypertensive Patients [Completed]
The primary objective was to determine the effects of the Gastrointestinal Therapeutic System (GITS) formulation of Doxazosin when used in combination therapy with the 5 major classes of antihypertensive agents as measure by 24-hour diastolic blood pressure.

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PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Cardura XL has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Cardura XL review by 65 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   BPH
Dosage & duration:   2 mg taken 1/day for the period of still do
Other conditions:   none
Other drugs taken:   Flomax before switching to Cardura
  
Reported Results
Benefits:   Increased urinary flow w/o the side effects of Flomax (decreased erectile strength). Available strengths are more varied with Cardura, thus effectiveness can be achieved with minimal dosage.
Side effects:   None with Cardura. I switched from Flomax because the minimum dosage of 4 mg reduced libido and erectile strength. Not completely, but "half-mast" so to speak.
Comments:   1 2mg tablet at night. Must be taken at the same time as effects last only 22-24 hours. This medication is also used to lower blood pressure, but at the dosage I am taking, my BP remains in the normal range of 75-80.

See all Cardura XL reviews / ratings >>

Page last updated: 2014-11-30

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