NEWS HIGHLIGHTSMedia Articles Related to Cardura XL (Doxazosin)
doxazosin mesylate, Cardura
Source: MedicineNet Benign Prostatic Hyperplasia Specialty [2009.02.20]
Title: doxazosin mesylate, Cardura
Category: Medications
Created: 12/31/1997
Last Editorial Review: 2/20/2009
Effects Of Once-Daily Tadalafil On Erectile Function In Men With Erectile Dysfunction And Signs And Symptoms Of Benign Prostatic Hyperplasia
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.07.12]
UroToday.com - Men with benign prostatic hyperplasia (BPH) often suffer from lower urinary tract symptoms (LUTS; BPH-LUTS) such as urinary frequency, urgency, intermittency, nocturia, straining, incomplete emptying, or weak urinary stream. BPH-LUTS and erectile dysfunction (ED), both highly prevalent conditions in aging men, are frequently associated in the same men, may have common pathophysiological mechanisms, and contribute negatively to quality of life.
Benign Prostatic Hyperplasia
Source: MedicineNet doxazosin mesylate Specialty [2008.06.23]
Title: Benign Prostatic Hyperplasia
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 6/23/2008
Published Studies Related to Cardura XL (Doxazosin)
Combination therapy with doxazosin and tenoxicam for the management of lower urinary tract symptoms. [2009.08]
CONCLUSIONS: COX-2 inhibitors in combination with an alpha blocker may increase the effectiveness of the therapy for LUTS secondary to BPH without significant effects on side effect profile.
Combination of doxazosin and sildenafil exerts an additive relaxing effect compared with each compound alone on human cavernosal and prostatic tissue. [2009.03]
INTRODUCTION: Phosphodiesterase 5 inhibitors (PDE5) such as sildenafil are first-line treatment for erectile dysfunction (ED). Alpha1 (alpha1)-adrenoceptor antagonists such as doxazosin are indicated for the treatment of patients with lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). ED and LUTS/BPH are conditions that are often associated. Accordingly, alpha1-adrenoceptor antagonists and PDE5 inhibitors will be often prescribed in real life setting together. AIM: To evaluate the effects of the combination of sildenafil and doxazosin on human cavernosal and prostatic tissue... CONCLUSIONS: Sildenafil and doxazosin reduced adrenergic tone of prostatic and cavernosal smooth muscle and their combination provided a significant benefit when targeting relaxation of both tissues. These experiments provide support for further clinical evaluation of the sildenafil and doxazosin combination in ED patients with LUTS/BPH.
Effect of vardenafil on blood pressure profile of patients with erectile dysfunction concomitantly treated with doxazosin gastrointestinal therapeutic system for benign prostatic hyperplasia. [2008.09]
PURPOSE: We investigated the effect of the combination of the doxazosin gastrointestinal therapeutic system and 10 mg vardenafil on the hemodynamic status of patients with benign prostatic hyperplasia and erectile dysfunction... CONCLUSIONS: In patients on the doxazosin gastrointestinal therapeutic system for benign prostatic hyperplasia a single 10 mg dose of vardenafil had no symptomatic hemodynamic effects.
Effect of Vardenafil on Blood Pressure Profile of Patients With Erectile Dysfunction Concomitantly Treated With Doxazosin Gastrointestinal Therapeutic System for Benign Prostatic Hyperplasia. [2008.07.16]
PURPOSE: We investigated the effect of the combination of the doxazosin gastrointestinal therapeutic system and 10 mg vardenafil on the hemodynamic status of patients with benign prostatic hyperplasia and erectile dysfunction... CONCLUSIONS: In patients on the doxazosin gastrointestinal therapeutic system for benign prostatic hyperplasia a single 10 mg dose of vardenafil had no symptomatic hemodynamic effects.
Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination. [2008]
INTRODUCTION: We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome... CONCLUSIONS: For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.
Clinical Trials Related to Cardura XL (Doxazosin)
Effects Of Doxazosin Gastrointestinal Therapeutic System On Ambulatory Blood Pressure And Cardiovascular Risk Factors In Uncontrolled Hypertensive Patients [Completed]
The primary objective was to determine the effects of the Gastrointestinal Therapeutic System
(GITS) formulation of Doxazosin when used in combination therapy with the 5 major classes of
antihypertensive agents as measure by 24-hour diastolic blood pressure.
The Efficacy of Doxazosin for Cocaine Users [Not yet recruiting]
Doxazosin, an alpha 1-adrenergic receptor may play an important role in cocaine addiction in
human. This study will evaluate the effectiveness of doxazosin in preventing drug relapse
among cocaine addicts.
Randomized Trial Comparing Terazosin 5 mg Daily and Doxazosin GITS 4 mg Daily for Trial Without Catheter in Acute Urinary Retention With Long Term Follow up [Terminated]
The purpose of the study is to compare two alpha blockers, terazosin and doxazosin GITS, in
achieving a successful TWOC after AUR due to BPH, among Chinese males in Hong Kong, and in
delaying or avoiding a TURP.
Combination Treatment With Doxazosin Plus TolterodineSR 2 mg Versus 4mg in Men With an Overactive Bladder (OAB) and Benign Prostatic Hyperplasia (BPH) [Recruiting]
OAB occurs in approximately 50% to 75% of men with BPO and up to 38% of men with BPO
continue to suffer from OAB after relief the obstruction. Symptoms of OAB are more bothersome
than the voiding complaints of slow stream and hesitancy. However, the patients with both
BPO and OAB are often not treated with muscarinic receptor antagonists due to concern that
they will experience acute urinary retention.
Tolterodine is a potent and pure muscarinic receptor antagonist that was developed
specifically for the treatment of overactive bladder. Recently, studies revealed that
tolterodine was effective, safe and well tolerated in adults with OAB and urodynamically
confirmed BPO. However, the optimal dosage of antimuscarinic for the treatment of OAB
coexisting BPO was not yet fully assessed. In real clinical situation, some patients
complain voiding difficulty after addition of antimuscarinics and want to stop
antimuscarinics. It is probable that a lower dosage of antimuscarinics combined with
alpha-adrenergic antagonists can be used safely in OAB patients with BOO, with the same
efficacy.
This study is designed to investigate the optimal doses of tolterodine SR in combination
with doxazosin in men with both BOO and OAB based on efficacy, safety, and tolerability.
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia [Recruiting]
In this study, we investigate the changes of the expression of alpha adrenergic receptor in
the prostate tissue during 2-yr medication period in the man with benign prostatic
hyperplasia. And we also evaluate the efficacy and safety of 24 mo-treatment with doxazosin
(4mg, 8mg)
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