Carbinoxamine (Carbinoxamine Maleate) - Description and Clinical Pharmacology

Rx only

Code 838A00

DESCRIPTION

Carbinoxamine maleate is a histamine-H₁ receptor blocking agent.

Each tablet contains 4 mg carbinoxamine maleate and the following inactive ingredients: anhydrous lactose, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate.

Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate (hydrous) and sorbitol solution.

Carbinoxamine maleate is freely soluble in water. Its structure is:

2-[(4-chlorophenyl)-2-pyridinylmethoxy]- N, N -dimethylethanamine (Z)-2-butenedioate (1:1)

C₁₆H₁₉CIN₂O• C₄H₄O₄                                                                                          MW = 406.86

CLINICAL PHARMACOLOGY

Carbinoxamine maleate is an antihistamine with anticholinergic (drying) and sedative properties.

Antihistamines appear to compete with histamine for receptor sites on effector cells.

The pharmacological effects of carbinoxamine maleate after oral absorption have been shown to last approximately 4 hours.

Interactions of carbinoxamine maleate with food or with other drugs and the possibility of cardiac conduction effects on the QT interval have not been studied.