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Carbastat (Carbachol Intraocular) - Description and Clinical Pharmacology

 
 



Carbastat®

C arbasta t ®

(CARBACHOL INTRAOCULAR SOLUTION, USP) 0.01%

DESCRIPTION

CARBASTAT®   (Carbachol Intraocular Solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. The active ingredient is represented by the structural formula:

Established name: Carbachol

Chemical name: Ethanaminium, 2-[(aminocarbonyl)oxy]- N,N,N -trimethyl-, chloride.

Each mL contains: Active: Carbachol 0.01%.

Inactive: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride dihydrate 0.048%, magnesium chloride hexahydrate 0.03%, sodium acetate trihydrate 0.39%, sodium citrate dihydrate 0.17%, sodium hydroxide and/or hydrochloric acid to adjust pH (5.0-7.5) and water for injection USP.

CLINICAL PHARMACOLOGY

Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known.

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