CARAFATE Tablets contain sucralfate and sucralfate is an (alpha)-D-glucopyranoside, ß-D-fructofuranosyl-, octakis-(hydrogen sulfate), aluminum complex.
CARAFATE® (sucralfate) is indicated in:
Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination.
Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.
Published Studies Related to Carafate (Sucralfate)
Efficacy of 10% sucralfate ointment in the reduction of acute postoperative pain
after open hemorrhoidectomy: a prospective, double-blind, randomized,
placebo-controlled trial. 
hemorrhoidectomy... CONCLUSIONS: Sucralfate ointment reduced the acute postoperative pain after
Sucralfate or placebo following argon plasma coagulation for chronic radiation
proctitis: a randomized double blind trial. 
CONCLUSION: APC is safe and effective for the management of chronic radiation
Topical sucralfate treatment of anal fistulotomy wounds: a randomized placebo-controlled trial. [2011.06]
BACKGROUND: Sucralfate is a cytoprotective agent which adheres to mucoproteins and forms a protective barrier at wound sites. In oral form it is a common ulcer medication, and as a topical preparation it has been used to treat a wide variety of wounds. OBJECTIVE: The present study was designed to evaluate the effectiveness and safety of topical sucralfate in wound healing after anal fistulotomy... CONCLUSIONS: The results of this study add support to the evidence that topical sucralfate is a safe and effective method for promoting mucosal healing and for providing analgesia during wound treatment. Patients undergoing anal fistulotomy can benefit from the use of topical application of sucralfate.
Topical sucralfate in post-adenotonsillectomy analgesia in children: a double-blind randomized clinical trial. [2009.09]
OBJECTIVES: Tonsillectomy, with or without adenoidectomy, is one of the most common surgical procedures in pediatric otolaryngology. Despite its relative simplicity, pain is the main cause of morbidity in the postoperative period. We determined the effect of topical sucralfate on reduction of oropharyngeal pain in children submitted to adenotonsillectomy. Secondary outcomes were otalgia, analgesic use, type of diet, secondary bleeding, vomiting, fever, and weight loss... CONCLUSION: We found beneficial effect of use of sucralfate in reduction of oropharyngeal pain in the postoperative period of adenotonsillectomy. However, topical sucralfate does not have a potent effect to the point of being utilized as a single analgesic treatment. Because it is simple, safe, tolerated, and low-cost, it is an important tool as adjuvant treatment of post-tonsillectomy pain.
Anti-inflammatory Effects of Rebamipide According to Helicobacter pylori Status in Patients with Chronic Erosive Gastritis: A Randomized Sucralfate-Controlled Multicenter Trial in China-STARS Study. [2008.11]
The aim of the study was to investigate the effects of rebamipide on symptom, histology, endogenous prostaglandin, and mucosal oxygen free radicals in chronic erosive gastritis (CEG) patients by using sucralfate as a control. The trial also examined whether Helicobacter pylori infection would affect rebamipide-induced protection...
Clinical Trials Related to Carafate (Sucralfate)
A Study to Evaluate the Efficacy of Teprenone On Chinese Patients With Chronic Non-Atrophic Erosive Gastritis [Recruiting]
Magic Mouthwash Plus Sucralfate Versus Benzydamine Hydrogen Chloride (HCl) for the Treatment of Radiation-Induced Mucositis [Recruiting]
Radiation treatment is very effective for treating cancers of the head and neck, however,
during the course of treatment, it is common for patients to experience soreness of their
mouth and throat due to the radiation. When radiation causes inflammation of the inside of
the mouth, it is called 'mucositis'. There are several mouthwashes that are commonly used to
prevent and treat mucositis, but none of these have been shown to be superior to another.
This study is being conducted to see if using a combination of magic mouthwash and
sucralfate is better than using a single mouthwash called benzydamine at decreasing the
burden of mucositis.
Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD) [Not yet recruiting]
The purpose of this study is to find out if people who have non-erosive reflux disease
(NERD) have changes the investigators can see with a microscope (called confocal
endomicroscopy) that is used during endoscopy (a camera scope evaluation of the inside of
your stomach and swallowing tube). Traditionally the investigators have used trials of acid
blocking medications (PPIs), endoscopy and measurements of acid in the swallowing tube (the
esophagus) to determine if the investigators think acid is causing troublesome symptoms. The
medical community believes that these symptoms are due to increased spaces between the cells
that make up the swallowing tube. The investigators can directly see those spaces with a new
microscope that the investigators can pass through the camera scope.
Participants will be assigned to take one of two medications omeprazole and sucralfate (both
approved medications for stomach symptoms) to treat their symptoms and record how well the
treatment works. The investigators then will look to see if the microscope can predict which
medication will work best for patients in the future. The investigators also plan to measure
the acid levels in your swallowing tube and do a camera evaluation of your swallowing tube
and stomach as this is standard for patients with your symptoms. The investigators will
compare the results of those studies to the microscope findings.
A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia [Completed]
Objective of this study was to determine incidence, risk factors, etiological micro-organisms
and their antimicrobial susceptibility pattern and outcome of VAP; and to study effect of
ranitidine vs. sucralfate, used for stress ulcer prophylaxis, on gastric colonization and on
occurrence of VAP.
Methods: Design: Prospective randomized study. Setting: ICUs of Medicine Department and
Anesthesiology Department, Maulana Azad Medical College and Lok Nayak Hospital, University of
Delhi, New Delhi. Patients: 50 patients of age more than 12 years, who had been on ventilator
for more than 48 hrs. Intervention: Endotracheal Aspirate and blood sample of all patients
were cultured to determine micro-organisms causing VAP and their antimicrobial susceptibility
pattern. Patients were divided into 2 groups on random basis. The first group was given
ranitidine for stress ulcer prophylaxis while the second was given sucralfate. Thereafter,
difference in gastric colonization (on basis of quantitative culture of nasogastric aspirate)
and on occurrence of VAP in both the groups was compared.
Study Hypothesis: Study was designed to create data about Ventilator associated pneumonia in
developing countries like India. This data is crucial for providing information for deciding
future guidelines for treatment of and prevention of Ventilator associated pneumonia. Further
to test the hypothesis that H2 blockers, by virtue of raising gastric Ph, increase gastric
colonization by pathogenic organism and increase incidence of Ventilator associated
pneumonia; patients were divided into two groups on random basis, as described above.
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit [Recruiting]
Although stress ulcer is a complication that can cause mortality and morbidity in critical
patients, there is still lack of consensus about its prophylaxis. There is also few data
available from Taiwan. H2 blockers are commonly used due to convenience. Some prefer
sucralfate (a mucosal protective agent) for the sake of less associated nosocomial
pneumonia. Recently, proton pump inhibitors were shown to have good prophylactic effects for
stress ulcer. Esomeprazole, an isoform of omeprazole, has good acid suppression effect and
the tablets are soluble for the use of tube feeding. Our previous study showed that there
was no difference for the efficacy of stress ulcer prophylaxis between esomeprazole and
sucralfate in patients admitted to medical ICU with at least one risk factor. The prevalence
of nosocomial pneumonia was also similar.
We will enroll those patients that have received intracranial surgery and admitted to
neurosurgical ICU. After obtaining the consent, we will give them prophylactic drugs for 7
days within 24 hours. They are randomly allocated to 2 groups. Group I: esomeprazole 40 mg
qd from NG route or orally; Group II: famotidine 20 mg iv bolus q12h. We will monitor the
following data: Glasgow coma scale, APACHE II score, CBC, CXR, stool character and OB test,
NG aspirate. If clinical evidence of UGI bleeding occurs, endoscopy will be performed. We
define the end point as overt bleeding, death or transfer out of ICU. We will compare the
prevalence of UGI bleeding and nosocomial pneumonia in these 2 groups.
Reports of Suspected Carafate (Sucralfate) Side Effects
Gastrooesophageal Reflux Disease (5),
OFF Label USE (4),
Feeling Abnormal (4),
Foreign Body (3),
Treatment Noncompliance (2),
Abdominal Pain Upper (2),
Malaise (2), more >>
Page last updated: 2014-11-30