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Carac (Fluorouracil Topical) - Summary

 
 



CARAC SUMMARY

Carac® (fluorouracil cream) Cream, 0.5%, contains fluorouracil for topical dermatologic use.

Carac is indicated for the topical treatment of multiple actinic or solar keratoses of the face and anterior scalp.


See all Carac indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Carac (Fluorouracil Topical)

Keratosis Pilaris
Source: MedicineNet Acne Specialty [2017.08.01]
Title: Keratosis Pilaris
Category: Diseases and Conditions
Created: 8/4/2008 12:00:00 AM
Last Editorial Review: 8/1/2017 12:00:00 AM

more news >>

Published Studies Related to Carac (Fluorouracil Topical)

Irsogladine maleate reduces the incidence of fluorouracil-based chemotherapy-induced oral mucositis. [2013]
mucositis through a double-blind, placebo controlled trial... CONCLUSION: IM significantly reduced the incidence and maximum severity of oral

Recurrence rates and patient assessed outcomes of 0.5% 5-fluorouracil in combination with salicylic acid treating actinic keratoses. [2012]
practicability... CONCLUSIONS: Topical 0.5% 5-FU/SA demonstrated superior sustained clinical

A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer. [2012]
maintenance therapy for metastatic colorectal cancer (MCRC)... CONCLUSIONS: Enzastaurin combined with bevacizumab-based therapy is tolerable,

Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. [2012]
for treatment of keloids... CONCLUSION: 5-FU tattooing was more effective than intralesional TAC for the

Therapeutic efficacy of combination therapy with intra-arterial 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced hepatocellular carcinoma with portal venous invasion. [2011.11.09]
BACKGROUND: The prognosis of advanced hepatocellular carcinoma (HCC) remains poor, particularly among patients with portal vein tumor thrombosis (PVTT). This study evaluated the efficacy of combined 5-fluorouracil and pegylated interferon (PEG-IFN) alpha-2b in patients with advanced HCC... CONCLUSIONS: Although a prospective randomized controlled trial using a larger population of patients with advanced HCC is needed to evaluate combination therapy with 5-fluorouracil and PEG-IFNalpha-2b, this new combination therapy may be useful for patients with advanced HCC. Cancer 2011;. (c) 2011 American Cancer Society. Copyright (c) 2011 American Cancer Society.

more studies >>

Clinical Trials Related to Carac (Fluorouracil Topical)

Retrospective Evaluation of 5-FU Exposure Optimization in CRC Patients [Enrolling by invitation]
The primary objective of this study is to evaluate whether the management of colorectal cancer (CRC) patients with 5-fluorouracil (5-FU) exposure optimization testing reduces 5-FU related toxicities and improves outcomes compared to the current standard of care. A secondary objective is to characterize the variability of 5-FU levels among CRC patients managed with 5-FU exposure optimization testing and the impact of such management on 5-FU plasma levels and drug doses during the course of chemotherapy.

Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients [Completed]
Phase I Objectives Primary: 1. The primary objective of this study is to determine the maximum tolerated dose (MTD) of Docetaxel combined with 5-Fluorouracil and Oxaliplatin (D-FOX) in patients with untreated, locally unresectable or metastatic adenocarcinoma of the stomach or gastroesophageal junction (GEJ). Secondary: 1. To determine the qualitative and quantitative toxicity and reversibility of toxicity of this combination. Phase II Objectives Primary: 1. To assess time to cancer progression to D-FOX treatment regimen. Secondary: 1. To assess response rate to D-FOX treatment regimen. 2. To determine the qualitative and quantitative toxicity and reversibility of toxicity of this combination treatment regimen. 3. Determine overall survival. 4. Perform an exploratory investigation into the effect of D-FOX on phenotypic abnormalities in blood.

A New Agent GM-CT-01 in Combination With 5-FU, Avastin and Leucovorin in Subjects With Colorectal Cancer [Terminated]
The purpose of this clinical trial is to determine whether the combination of 5-fluorouracil (5-FU) plus a DAVANAT (carbohydrate polymer) along with Avastin and Leucovorin (LV) is beneficial in treating colorectal cancer in patients unable to tolerate intensive chemotherapy.

Safety and Tolerability Study of Ingenol Mebutate Compared to 5-FU to Treat Facial Actinic Keratosis [Completed]
Background: 5% 5-fluorouracil cream (5-FU) is a well-established treatment for actinic keratosis (AK) and ingenol mebutate gel (IMB) is a new topical field therapy. Objective: To compare tolerability and safety of IMB with 5-FU for the treatment of facial AKs. Methods: Open-label, prospective, randomized, controlled clinical trial with 100 patients with AKs within 25-cm2 contiguous field on the face. IMB was applied daily for three consecutive days. 5-FU was applied twice a day for four weeks. Treatment effect was evaluated at baseline and on days 2, 3, 4, 8, 15, 22, 29, 36 and 43, considering ITT populations.

Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX) [Active, not recruiting]
The goal of this clinical research study is to find the highest tolerable doses of the combinations of lenalidomide and other drugs that can be given to patients with advanced cancer. The safety of the drug combinations will also be studied.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Carac has an overall score of 7.67. The effectiveness score is 8.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Carac review by 47 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Pre Cancer cells
Dosage & duration:   once a day for 3 weeks (dosage frequency: once a day) for the period of 2 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Carac is used once a day as a topical cream in order to remove pre cancerous cells. It did a great job of removing all bad cells. I used it before going to bed. I only used it 2 weeks because I had the reaction quicker than most.
Side effects:   The side effects are that your face becomes very red - like a bad sunburn.
Comments:   You put the cream (Carac) on the bad cells whereever they may be, once a day for three weeks. Over time you skin will have a reaction, become like a bad sunburn and then begin to peel. Carac will only attack the fast growing bad cells. I had a great reaction to Carac so it worked extremely well for me.

 

Carac review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   red spot on the cheek
Dosage & duration:   0.5% (dosage frequency: once in the evening) for the period of 3 weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   carac got rid of the pre-cancerous spot and was not left with a scar
Side effects:   burning eye by where it was applied. couldn't sleep well.
Comments:   I would apply the carac cream to cleansed area and have the wash my hands immediatley after applying. In the morning I would dap off the residue and apply sunscreen. I did this for 3 weeks.

 

Carac review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   red spot on the cheek
Dosage & duration:   0.5% (dosage frequency: once in the evening) for the period of 3 weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   carac got rid of the pre-cancerous spot and was not left with a scar
Side effects:   burning eye by where it was applied. couldn't sleep well.
Comments:   I would apply the carac cream to cleansed area and have the wash my hands immediatley after applying. In the morning I would dap off the residue and apply sunscreen. I did this for 3 weeks.

See all Carac reviews / ratings >>

Page last updated: 2017-08-01

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