CLINICAL PHARMACOLOGY
Well controlled studies demonstrate Capitrol effectively reduces the excess scaling in patients with dandruff or seborrheic dermatitis. Though the cause of dandruff is not known, it is thought to be the result of accelerated mitotic activity in the epidermis. The presumed mechanism of action to reduce scaling would be to slow down the mitotic activity.
The role of microbes in seborrheic dermatitis is not known; however, Staphylococcus aureus and Pityrosporon species are often present in increased numbers during the course of the disease. Chloroxine is antibacterial, inhibiting the growth of Gram-positive as well as some Gram-negative organisms. Antifungal activity against some dermatophytes and yeasts also has been shown.
The absorption, metabolism and pharmacokinetics of Capitrol in humans have not been studied.
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