Media Articles Related to Capital and Codeine (Acetaminophen / Codeine)
Painkillers for non-cancer chronic pain: New insights on risk
Source: Depression News From Medical News Today [2015.02.21]
Studies show need for alternative, non-medication approachesIt's been seven years since actor Heath Ledger, only 28, was found dead in his Manhattan apartment.
Headaches Quiz: Test Your Headache Pain IQ
Source: MedicineNet Headache Specialty [2015.02.20]
Title: Headaches Quiz: Test Your Headache Pain IQ
Category: MedicineNet Quiz
Created: 9/28/2010 11:09:00 AM
Last Editorial Review: 2/20/2015 5:14:04 PM
New hope in the fight against pain
Source: Neurology / Neuroscience News From Medical News Today [2015.02.19]
An international study led by scientists at McGill University reports, for the first time, that drugs that selectively target the melatonin MT2 receptor represent a novel class of analgesic drugs...
Myofascial Pain Syndrome
Source: MedicineNet Chronic Fatigue Syndrome Specialty [2015.02.19]
Title: Myofascial Pain Syndrome
Category: Diseases and Conditions
Created: 2/4/2005 12:00:00 AM
Last Editorial Review: 2/19/2015 12:00:00 AM
Does Methotrexate Improve Osteoarthritis Pain?
Source: Medscape Pharmacists Headlines [2015.02.18]
Can this disease-modifying antirheumatic drug improve symptoms of osteoarthritis? What does the research find?
Published Studies Related to Capital and Codeine (Acetaminophen / Codeine)
Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. [2006.04]
OBJECTIVE: To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain. STUDY DESIGN: Open-label active-controlled randomized naturalistic 4-month study of oxycodone vs a combination of oxycodone-acetaminophen (Percocet)... CONCLUSIONS: From the societal perspective, oxycodone was more effective and less costly than oxycodone-acetaminophen. From the healthcare perspective, oxycodone (compared with generic oxycodone-acetaminophen) fell within the acceptable range of cost-effectiveness between 50,000 US dollars and 100,000 US dollars per QALY gained.
Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. [2005.10]
OBJECTIVE: To determine analgesic efficacy of a single oral dose of rofecoxib 50 mg compared with acetaminophen/codeine 600/60 mg, we conducted a double-blind, randomized, placebo- and active-comparator-controlled, parallel-group study... CONCLUSION: Rofecoxib provided superior analgesic efficacy compared with codeine/acetaminophen with fewer gastrointestinal and nervous system adverse events.
Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. [2009.10]
OBJECTIVES: To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN: Prospective, double-blind, randomized trial. SETTING: Accredited outpatient surgery centre... CONCLUSIONS: Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.
Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials. [2009.08]
BACKGROUND: Cesarean section, episiotomy, and third and perineal tears are associated with significant tissue damage, causing pain in the immediate postpartum period. The current standard in North America is to prescribe oral acetaminophen/codeine (A + C) for postpartum pain. Codeine has opioid-related adverse effects and may not be safe during breastfeeding in the postpartum period for all neonates. Nonsteroidal anti-inflammatory drugs (NSAIDs) are devoid of opioid-related adverse effects and could be a possible alternative for analgesia in postpartum pain. The objective of this systematic review was to compare the analgesic effect and safety profile of acetaminophen/codeine (A + C) with NSAIDs in the management of pain after laparotomy... CONCLUSIONS: None of the studies found A + C to be superior to NSAIDs in controlling postlaparotomy pain. NSAIDs appear to be an equipotent alternative in the treatment of postlaparotomy pain. Four of the 9 studies reported less adverse effects in the NSAID group. There appears to be an overall better risk/benefit ratio for the use of NSAIDs for postpartum pain.
Clinical Trials Related to Capital and Codeine (Acetaminophen / Codeine)
Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis [Recruiting]
This study is being done for two reasons: 1) to evaluate growth problems in the hip in
patients with Slipped Capital Femoral Epiphysis (SCFE) as they continue to grow into adults,
and 2) to help doctors determine which patients are at risk for developing a SCFE on their
opposite hip. Studies show that up to 60% of patients with a SCFE will go on to develop a
SCFE on their other side. Being able to better determine which patients are at risk for
developing a SCFE on the other side will help physicians better monitor patients with a
history of a SCFE and perhaps treat them before they develop a SCFE on the opposite side. By
studying the growth centers seen on X-rays of your child's legs and elbow, the investigators
may be able to better predict which children with a SCFE are at risk for developing a SCFE
on their opposite hip and potential growth problems as they continue to grow.
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
Fibrinogen Concentrate as Initial Treatment for Postpartum Haemorrhage: A Randomised Clinically Controlled Trial [Recruiting]
Severe maternal bleeding is a serious complication of birth and causes 125. 000 deaths
worldwide each year. The investigators aim to investigate if early treatment with fibrinogen
concentrate versus saline can reduce the incidence of blood transfusion in women with
A low level of fibrinogen has been associated with increased blood loss and transfusion
requirements in different clinical settings including obstetrical bleeding. Early up-front
treatment with fibrinogen may reduce incidence of transfusion by securing optimal
haemostatic capacity in women with postpartum haemorrhage.
The investigators plan to enrol 245 patients on four hospitals in the Capital Region of
Denmark during a two year period.
As safety measure the investigators plan to use TEG®/Functional Fibrinogen/Rapid-TEG as
haemostatic monitoring of all participants during the trial: Baseline test is taken at
inclusion before administration of fibrinogen concentrate/placebo. Further tests are taken
immediately after intervention, 4 hours and 24 hours after. Baseline test is blinded to the
providers of treatment - the rest is clinically available.
Community-based Accompaniment With Supervised Antiretrovirals in Lima, Peru [Recruiting]
Using quantitative and qualitative data, this study will assess the impact of community
accompaniment with supervised antiretrovirals (CASA) on HIV-positive individuals and
community members in Lima, Peru.
To Investigate the Prevalence of Children Asthma in China [Not yet recruiting]
Asthma is the most common chronic respiratory disease in children and has much effect on
their life and study, which leads to huge economic burden and pressure to the whole
families. Some children will develop into adult patients so that asthma can be the life-long
vigorous trouble. In recent years, the prevalence rate of children asthma is increasingly
going up worldwide. The prevalence rate in last 12 months reported in USA, United Kingdom,
Australia, New Zealand was between 12% to 30%.
Center for Asthma Prevention and Education of Capital Institute of Pediatrics investigated
the national asthma prevalence in 900 thousands children in 27 provinces and cities, which
average rate was 0. 11% to 2. 03% in 1990. In 2000, we investigated it again in 31
provinces(43 cities) and the average national children asthma prevalence rate was
1. 97%(0. 25% to 4. 63%) which was much higher than that in 1990.