NEWS HIGHLIGHTSMedia Articles Related to Capital and Codeine (Acetaminophen / Codeine)
Ibuprofen Bests Acetaminophen/Codeine for Kids' Broken Arms (CME/CE)
Source: MedPage Today Emergency Medicine [2009.08.19]
Children treated for arm fractures reported that ibuprofen killed the pain as effectively as a combination of codeine and acetaminophen (Tylenol 3), with fewer adverse effects in a randomized trial.
Yoga May Be Effective For Chronic Low Back Pain In Minority Populations
Source: Health News from Medical News Today [2009.11.05]
Researchers from Boston University School of Medicine (BUSM) and Boston Medical Center found that yoga may be more effective than standard treatment for reducing chronic low back pain in minority populations. This study appears in the November issue of Alternative Therapies in Health and Medicine.
Radiation Therapy Technique Successfully Treats Pain In Patients With Advanced Cancer
Source: Cancer / Oncology News From Medical News Today [2009.11.05]
Stereotactic radiosurgery (SRS), a radiation therapy procedure pioneered at the University of Pittsburgh Cancer Institute (UPCI) that precisely delivers a large dose of radiation to tumors, effectively controls pain in patients with cancer that has spread to the spine, according to researchers from UPCI. The results of the research were presented this week during the American Society for Radiation Oncology (ASTRO) annual meeting in Chicago, being held November 1 - 5, 2009.
Common Pain Relievers May Dilute Power Of Flu Shots
Source: Biology / Biochemistry News From Medical News Today [2009.11.04]
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers -- Advil, Tylenol, aspirin -- at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D.
Cancer, Pain Relief And Immunity Research Supported By ARC
Source: Breast Cancer News From Medical News Today [2009.11.04]
Research at the Walter and Eliza Hall Institute into the genes involved in breast cancer development, new drugs for chronic pain, and the proteins involved in inflammatory diseases has received funding in this year's round of Australian Research Council (ARC) Discovery Project grants. Seven projects proposed by institute researchers have received ARC support.
Published Studies Related to Capital and Codeine (Acetaminophen / Codeine)
Economic evaluation of controlled-release oxycodone vs oxycodone-acetaminophen for osteoarthritis pain of the hip or knee. [2006.04]
OBJECTIVE: To examine, in routine practice, the effectiveness and cost-effectiveness of oxycodone (OxyContin) compared with standard therapy for osteoarthritis pain. STUDY DESIGN: Open-label active-controlled randomized naturalistic 4-month study of oxycodone vs a combination of oxycodone-acetaminophen (Percocet)... CONCLUSIONS: From the societal perspective, oxycodone was more effective and less costly than oxycodone-acetaminophen. From the healthcare perspective, oxycodone (compared with generic oxycodone-acetaminophen) fell within the acceptable range of cost-effectiveness between 50,000 US dollars and 100,000 US dollars per QALY gained.
Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. [2005.10]
OBJECTIVE: To determine analgesic efficacy of a single oral dose of rofecoxib 50 mg compared with acetaminophen/codeine 600/60 mg, we conducted a double-blind, randomized, placebo- and active-comparator-controlled, parallel-group study... CONCLUSION: Rofecoxib provided superior analgesic efficacy compared with codeine/acetaminophen with fewer gastrointestinal and nervous system adverse events.
Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. [2009.10]
OBJECTIVES: To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN: Prospective, double-blind, randomized trial. SETTING: Accredited outpatient surgery centre... CONCLUSIONS: Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.
Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials. [2009.08]
BACKGROUND: Cesarean section, episiotomy, and third and perineal tears are associated with significant tissue damage, causing pain in the immediate postpartum period. The current standard in North America is to prescribe oral acetaminophen/codeine (A + C) for postpartum pain. Codeine has opioid-related adverse effects and may not be safe during breastfeeding in the postpartum period for all neonates. Nonsteroidal anti-inflammatory drugs (NSAIDs) are devoid of opioid-related adverse effects and could be a possible alternative for analgesia in postpartum pain. The objective of this systematic review was to compare the analgesic effect and safety profile of acetaminophen/codeine (A + C) with NSAIDs in the management of pain after laparotomy... CONCLUSIONS: None of the studies found A + C to be superior to NSAIDs in controlling postlaparotomy pain. NSAIDs appear to be an equipotent alternative in the treatment of postlaparotomy pain. Four of the 9 studies reported less adverse effects in the NSAID group. There appears to be an overall better risk/benefit ratio for the use of NSAIDs for postpartum pain.
Clinical Trials Related to Capital and Codeine (Acetaminophen / Codeine)
A Randomized, Double-Blind, Placebo-Controlled Study on the Effect of CVT-E002 in Patients With Seasonal Allergic Rhinitis [Recruiting]
You are being asked to take part in a research study of COLD-fX, a product designed to boost
the immune system. COLD-fX is an extract from the roots of North American ginseng and it may
offer some benefit to people with seasonal allergies.
The purpose of the present study is to find out how effective and safe COLD-fX is in
improving quality of life and reducing symptoms of seasonal allergies such as hay fever.
COLD-fX is not yet approved for treatment of seasonal allergies. We are seeking to enroll
200 participants in the Capital Health region.
The Incidence of Intra-Operative Awareness in China and Analysis of Relevant Factors: a Multicentre Study [Recruiting]
Medical literature about awareness during general anesthesia is rare in China, and some small
sampled studies in China showed a significantly higher incidence (1. 5～6%) of intra-operative
awareness compared with western countries. We sponsored this multicenter, large sampled,
prospective study to determine the incidence of intra-operative awareness in China, and the
preservation effect of BIS monitor on the incidence of awareness.
CAPITAL: Carotid Artery Plaque Intravascular Ultrasound Evaluation [Completed]
To assess the safety and feasibility of Volcano Corp Eagle Eye Gold Catheter system to
correlate the presence and characteristic of carotid artery atherosclerotic disease with
anatomic and histologic analysis.
Genetic Identification (ID) of Segmental Dysplastic Nevi [Not yet recruiting]
The investigators' goal is to identify the mutation in the gene that is responsible for the
development of segmental dysplastic nevi. To identify the gene the investigators may use a
candidate gene approach (i. e. sequence specific genes that are thought to be involved: NRAS,
BRAF, etc) or a genome-wide approach trying to implicate regions in the genome
(Loss-of-heterozygosity or copy number changes on comparative genomic hybridization).
The Effects of Peri-Operative Pregabalin on Post-Operative Pain Following Breast Cancer Surgery With Axillary Node Dissection: A Pilot Study [Recruiting]
Breast cancer is a devastating disease. Some women with breast cancer undergo surgery to
remove the breast and lymph nodes in the axilla (armpit). Unfortunately, surgery of this
type is associated with pain both in the days immediately following the operation and in the
long term. Pain that continues for more than three months after surgery is known as chronic
pain and affects as many as 1/5 to more than ½ of patients having this surgery. Often this
pain is of a particular type known as neuropathic pain. There have been studies
demonstrating that the intensity of pain after surgery may be related to the likelihood of
developing chronic pain. It is important to develop methods to reduce acute pain after
breast cancer surgery and to reduce chronic pain for breast cancer survivors.
Pregabalin is a medication used in the treatment of chronic pain. It has been shown to be
effective for neuropathic pain. There has also been one study demonstrating its
effectiveness in reducing pain after dental extraction. We are interested in determining
whether pregabalin taken for 14 days starting the day of surgery will reduce acute (short
term) pain and chronic pain from this type of breast cancer surgery.
In order to test ability of pregabalin for the reduction of chronic pain it may be necessary
to follow a large number of patients for up to one year after surgery. This may require
studying patients in more than one institution. Prior to starting such a large study we are
proposing a pilot or preliminary study. This study will follow a smaller group of
participants (68) for 6 months. From the pilot study we will determine the effect of
pregabalin on acute pain and logistic and statistical information required for the full
study. We will randomly assign participants to receive pregabalin or placebo (sugar pills)
for twice daily for 14 days starting one hour before surgery. We will monitor the
participants' pain at one hour after surgery, 24 hours after surgery, one week, two weeks,
three months and six months after surgery. We will also monitor for a number of other
parameters such as medication side effects and the need for other pain medications.
Recruitment of study participants is expected to take 6-7 months.
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