Calcium Disodium Versenate (edetate calcium disodium injection, USP) is a sterile, injectable, chelating agent in concentrated solution for intravenous infusion or intramuscular injection. Each 5 ml ampul contains 1000 mg of edetate calcium disodium (equivalent to 200 mg/ml) in water for injection.
Edetate calcium disodium is indicated for the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Chelation therapy should not replace effective measures to eliminate or reduce further exposure to lead.
Published Studies Related to Calcium Disodium Versenate (Edetate Calcium Disodium)
Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate. [2010.11]
BACKGROUND: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. OBJECTIVE: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of a low-fat margarine... CONCLUSIONS: When used to evaluate the efficacy of iron fortificants, random serial sampling can reduce the sample size, invasiveness, and costs while increasing sensitivity. Random serial sampling more clearly describes the pattern of iron repletion and may prove useful in evaluating other micronutrient interventions.
Atomic absorption spectrometry and scanning electron microscopy evaluation of concentration of calcium ions and smear layer removal with root canal chelators. [2009.05]
AIM: The aim of this study was to evaluate the concentration of calcium ions and smear layer removal by using root canal chelators according to flame atomic absorption spectrophotometry and scanning electron microscopy. Forty-two human maxillary central incisors were irrigated with 15% ethylenediaminetetraacetic acid (EDTA), 10% citric acid, 10% sodium citrate, apple vinegar, 5% acetic acid, 5% malic acid, and sodium hypochlorite...
Bacterial leakage in root canals filled with calcium hydroxide paste associated with different vehicles. 
This in vitro study evaluated, using a bacterial leakage model, whether intracanal medication with calcium hydroxide [Ca(OH)2]-based pastes prepared with different vehicles, has inhibitory effect on corono-apical leakage of bacteria. Forty instrumented human canines were dressed with Ca(OH)2 p.a...
Effect of calcium hydroxide intracanal dressing on the bond strength of a resin-based endodontic sealer. 
The aim of this in vitro study was to evaluate the bond strength of Epiphany resin-based sealer to dentin walls after placement of calcium hydroxide [Ca(OH)2] dressings. Fifteen extracted single-rooted human teeth were instrumented using 2.5% NaOCl + EDTA as irrigants... It may be concluded that the use of Ca(OH)2 as an intracanal dressing material affected the adhesion of Epiphany to the root canal walls, but even though the values were within the acceptable range found in the literature.
Effects of conditioners on microshear bond strength to enamel after carbamide peroxide bleaching and/or casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) treatment. [2007.11]
OBJECTIVES: To evaluate (a) the enamel microshear bond strength (MSBS) of a universal adhesive and (b) the effects of conditioning with a self-etching primer adhesive with/without prior bleaching and/or casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) application... CONCLUSIONS: The use of conditioners prior to bonding with the self-etching primer adhesive system on treated enamel may significantly improve bond strengths.
Clinical Trials Related to Calcium Disodium Versenate (Edetate Calcium Disodium)
Calcium, Dairy, and Body Fat in Adolescents [Completed]
Lifestyle choices,including diet,are conducive to healthy body weights in children. Dairy
products and calcium supplementation have been associated with moderation of body weight and
body fat. This study was designed to test the following hypotheses with overweight and obese
adolescents consuming a controlled diet:
- Dietary calcium supplementation as calcium carbonate or dairy calcium modulates energy
balance in adolescents.
- Increased calcium in the diet of adolescents will increase fecal fat excretion and
thereby decrease fat absorption.
- Calcium and dairy product supplementation will increase lipid oxidation resulting in an
increase in energy expenditure.
Supplimentation With 2000IU Vitamin D, 1gm Calcium or Both on Calcium Absorption and BMC in Children With JRA [Completed]
2000IU vitamin D, 1gm calcium, or both given to children with Juvenile Rheumatoid Arthritis
may increase percent true calcium absorption, bone mineral turnover and/or bone
Calcium Absorption and Retention From Marine Products [Active, not recruiting]
The purpose of the study is to determine the uptake of calcium from fish bone meal from
salmon and cod in 12 healthy volunteers. A test meal labelled with trace amounts of a
readioactive calcium isotope (Ca47) will be given after an overnight fast and whole body
retention of calcium will be measured on day 13, 21, and 24 after the test meal day.
Calcium Metabolism in Asian Adolescents [Completed]
Maximizing calcium retention by the skeleton within the genetic potential is a key strategy
to prevent osteoporosis. It has been shown that calcium retention varies between blacks and
whites and between gender within race. This study is designed to study the relationship
between calcium intakes and calcium retention in Asian adolescent girls and boys. It is
hypothesized that calcium intakes which maximize calcium retention will be lower in Asians
than for whites studies under the same conditions. In addition it is thought that the
differences between races in the physiological mechanisms involved in calcium metabolism will
result in a lower calcium intake required to observe a plateau in calcium retention. This is
turn could be translated into lower calcium requirements in Asians relative to Caucasians for
achieving optimal peak bone mass.
Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection [Completed]
the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection
can be minimized by routine administration of oral calcium and vitamin D supplements during
the early postoperative period.