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Calcium Disodium Versenate (Edetate Calcium Disodium Injection) - Summary

 

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WARNINGS:

Calcium Disodium Versenate is capable of producing toxic effects which can be fatal. Lead encephalopathy is relatively rare in adults, but occurs more often in pediatric patients in whom it may be incipient and thus overlooked. The mortality rate in pediatric patients has been high. Patients with lead encephalopathy and cerebral edema may experience a lethal increase in intracranial pressure following intravenous infusion; the intramuscular route is preferred for these patients. In cases where the intravenous route is necessary, avoid rapid infusion. The dosage schedule should be followed and at no time should the recommended daily dose be exceeded.

 

SUMMARY

Calcium Disodium Versenate (edetate calcium disodium injection, USP) is a sterile, injectable, chelating agent in concentrated solution for intravenous infusion or intramuscular injection. Each 5 ml ampul contains 1000 mg of edetate calcium disodium (equivalent to 200 mg/ml) in water for injection.

Edetate calcium disodium is indicated for the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.

Chelation therapy should not replace effective measures to eliminate or reduce further exposure to lead.

NEWS HIGHLIGHTS RELATED TO CALCIUM DISODIUM VERSENATE

Published Studies Related to Calcium Disodium Versenate (Edetate Calcium Disodium)

Effects of conditioners on microshear bond strength to enamel after carbamide peroxide bleaching and/or casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) treatment. [2007.11]

Calcium loss from root canal dentin following EDTA, EGTA, EDTAC, and tetracycline-HCl treatment with or without subsequent NaOCl irrigation. [2007.05]

A randomised double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy. [2007.05]

Removal efficacy of various calcium hydroxide/chlorhexidine medicaments from the root canal. [2006.01]

Effect of oral calcium disodium EDTA on iron absorption in a human model of iron overdose. [2006]

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Clinical Trials Related to Calcium Disodium Versenate (Edetate Calcium Disodium)

Calcium, Dairy, and Body Fat in Adolescents [Completed]

Supplimentation With 2000IU Vitamin D, 1gm Calcium or Both on Calcium Absorption and BMC in Children With JRA [Completed]

Calcium Absorption and Retention From Marine Products [Active, not recruiting]

Calcium Metabolism in Asian Adolescents [Completed]

Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection [Completed]

more>>

Page last updated: 2007-10-18

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