Calcijex (Calcitriol) - Description

DESCRIPTION

Calcijex® (calcitriol injection) is synthetically manufactured calcitriol and is available as a sterile, isotonic, clear, colorless to yellow, aqueous solution for intravenous injection. Calcijex® is available in 1 mL ampuls. Each 1 mL contains calcitriol, 1 mcg; Polysorbate 20, 4 mg; sodium ascorbate 2.5 mg added. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. pH is 6.5 (5.9 to 7.0). Contains no more than 1 mcg/mL of aluminum.

Calcitriol is a crystalline compound which occurs naturally in humans. It is soluble in organic solvents but relatively insoluble in water.

Calcitriol is chemically designated (5Z,7E)-9, 10-sec-ocholesta-5,7,10(19)-triene-1(alpha),3(beta),25-triol and has the following structural formula:

Molecular Formula: C₂₇H₄₄O₃

The other names frequently used for calcitriol are 1(alpha),25-dihydroxycholecalciferol, 1(alpha),25-dihydroxyvitamin D₃, 1,25-DHCC, 1,25(OH) ₂D₃ and 1,25-diOHC.