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Cafcit (Caffeine Citrate) - Summary



Both CAFCIT® (caffeine citrate) Injection for intravenous administration and CAFCIT® (caffeine citrate) Oral Solution are clear, colorless, sterile, non-pyrogenic, preservative-free, aqueous solutions adjusted to pH 4.7. Each mL contains 20 mg caffeine citrate (equivalent to 10 mg of caffeine base) prepared in solution by the addition of 10 mg caffeine anhydrous to 5.0 mg citric acid monohydrate, 8.3 mg sodium citrate dihydrate and Water for Injection. Caffeine, a central nervous system stimulant, is an odorless white crystalline powder or granule, with a bitter taste. It is sparingly soluble in water and ethanol at room temperature. The chemical name of caffeine is 3,7-dihydro-1,3,7-trimethyl-1 H -purine-2,6-dione. In the presence of citric acid it forms caffeine citrate salt in solution.

CAFCIT (caffeine citrate) is indicated for the short-term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.

See all Cafcit indications & dosage >>


Media Articles Related to Cafcit (Caffeine)

Do Your Patients Consume Enough Caffeine?
Source: Medscape Critical Care Headlines [2015.08.19]
A major evidence review concludes that recommending caffeine/coffee for its health benefits is largely premature.
Medscape Critical Care

Nicotine "no more harmful to health than caffeine"
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.08.13]
Public confusion reigns with 9 in 10 believing nicotine is harmful to healthThe Royal Society for Public Health (RSPH) is calling for public confusion over nicotine to be addressed as a way...

Source: MedicineNet Colic Specialty [2015.02.18]
Title: Caffeine
Category: Health and Living
Created: 6/26/2007 12:00:00 AM
Last Editorial Review: 2/18/2015 12:00:00 AM

Coffee linked to heart attack for persons with certain gene
Source: The Doctors Lounge - Cardiology
Persons with a genetic variation may have slower caffeine metabolism according to a study in the March 8 issue of JAMA.

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Published Studies Related to Cafcit (Caffeine)

Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. [2013]
to opioid therapy in patients with advanced cancer... CONCLUSION: Caffeine infusion significantly reduced pain and drowsiness, but the

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. [2012]
CONCLUSIONS: Subcutaneous sumatriptan is effective as an abortive

Caffeine and opening the eyes have additive effects on resting arousal measures. [2011.10]
CONCLUSIONS: Caffeine and opening the eyes have additive effects on two measures of arousal, increasing SCL and reducing global EEG alpha. However, the independent variable effects are not equivalent, suggesting that one or both measures reflect additional non-arousal processes. SIGNIFICANCE: As caffeine is widely used by both children and adults, knowledge of the additivity of arousal effects of caffeine and opening the eyes is important in controlling participant state in EEG studies. The current results confirm the use of mean global alpha amplitude as a measure of resting-state arousal, but also point to non-arousal effects of visual input. Copyright (c) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Caffeine ingestion, affect and perceived exertion during prolonged cycling. [2011.08]
Caffeine's metabolic and performance effects have been widely reported. However, caffeine's effects on affective states during prolonged exercise are unknown...

Effect of a single and repeated dose of caffeine on antigen-stimulated human natural killer cell CD69 expression after high-intensity intermittent exercise. [2011.07]
Several studies investigating the effect of caffeine on immune function following exercise have used one large bolus dose of caffeine. However, this does not model typical caffeine consumption... These findings suggest that although one large bolus dose of caffeine attenuated the exercise-induced increase in antigen-stimulated NK cell CD69 expression 1 h following strenuous intermittent exercise, this attenuation at no point fell below pre-supplement values and caffeine does not appear to depress NK cell CD69 expression.

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Clinical Trials Related to Cafcit (Caffeine)

Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans? [Suspended]
We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Neurophysiological Reserve With Caffeine Manipulation [Not yet recruiting]
The objective of this study is to verify if there is a neurophysiologic reserve when caffeine and placebo perceived as caffeine are manipulated in closed- and opened-loop exercises. Parameters of excitability level of skeletal muscle and Central Nervous System (CNS), and peripheral metabolism will be measured

Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence [Recruiting]
The aim of this study is to assess the efficacy of caffeine compared to placebo as a maintenance treatment for cocaine dependence. Caffeine potentiation with biperiden will be also studied. Ninety patients with snorted/sniffed cocaine dependence will be randomized to receive

caffeine (300 - 1200 mg t. i.d.) plus biperidene (8 mg b. i.d.) caffeine (300 - 1200 mg

t. i.d.) with placebo or placebo during 10 days in an in-hospital setting.

Caffeine for Excessive Daytime Somnolence in Parkinson's Disease [Recruiting]
Many patients with Parkinson's disease (PD) have sleep problems, including excessive sleepiness during the day. This is probably due to degeneration of sleep-regulating areas in the brain. At present, the only treatment for sleepiness in PD is modafinil, which is expensive and only partially effective. There is another potential treatment for sleepiness

that is used worldwide, is inexpensive, well tolerated and safe - namely, caffeine. There

have also been suggestions that caffeine may slow the progression of degeneration in PD, since coffee non-drinkers are at higher risk of developing PD. PD patients, even with severe sleepiness often do not use caffeine. It is unclear whether this is because their PD makes their sleepiness unresponsive to caffeine, because they cannot tolerate it, or whether this reflects their lifelong habit of non-use. This proposal outlines a trial in which patients with excessive sleepiness will be given caffeine or placebo (no therapy) in a blinded fashion. In this way, the effect of caffeine on sleepiness and motor symptoms can be directly analyzed. In addition, these findings can be used to test the tolerability of caffeine, to help plan a larger-scale study testing whether caffeine can slow the progression of PD

Comparison of Caffeine Reduction and Anticholinergic Medications for Treatment of Overactive Bladder [Recruiting]
The purpose of this study is to assess the effects of caffeine reduction/elimination on urinary symptoms in women with overactive bladders and compare this therapeutic approach to anticholinergic therapy. We hope to show a reduction in symptoms with caffeine reduction and determine how effective caffeine reduction is compared to medication. If caffeine reduction is shown to be beneficial, women may be encouraged to use this strategy before resorting to medications.

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Page last updated: 2015-08-19

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