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Byetta (Exenatide Injection) - Summary

 


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BYETTA SUMMARY

BYETTA® (exenatide) is a synthetic peptide that has incretin-mimetic actions and was originally identified in the lizard Heloderma suspectum. BYETTA enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying. Exenatide differs in chemical structure and pharmacological action from insulin, sulfonylureas (including D-phenylalanine derivatives and meglitinides), biguanides, thiazolidinediones, and alpha-glucosidase inhibitors. Exenatide is a 39−amino acid peptide amide.

BYETTA is indicated as adjunctive therapy to improve glycemic control in patients with type 2 diabetes mellitus who are taking metformin, a sulfonylurea, a thiazolidinedione, a combination of metformin and a sulfonylurea, or a combination of metformin and a thiazolidinedione, but have not achieved adequate glycemic control.


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BYETTA NEWS HIGHLIGHTS

Media Articles Related to Byetta (Exenatide Injection)

6 Deaths Reported From Diabetes Drug Byetta
Source: MedicineNet Gallstones Specialty [2008.08.28]

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Published Studies Related to Byetta (Exenatide Injection)

Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. [2008.08]

Effects of exenatide versus insulin analogues on weight change in subjects with type 2 diabetes: a pooled post-hoc analysis. [2008.03]

Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. [2008.01]

Effect of renal impairment on the pharmacokinetics of exenatide. [2007.09]

Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. [2007.06]

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Clinical Trials Related to Byetta (Exenatide Injection)

Effects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1) [Active, not recruiting]

An Exploratory Study of the Effect of Treatment Interruption on Safety of Exenatide in Patients With Type 2 Diabetes [Completed]

Efficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s) [Active, not recruiting]

A Study by Scintigraphy to Evaluate the Effect of Exenatide on Gastric Emptying in Subjects With Type 2 Diabetes [Completed]

Safety and Efficacy of Exenatide as Monotherapy [Completed]

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BYETTA PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Byetta has an overall score of 10. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Byetta review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   diabetes
Dosage & duration:   10mcg (dosage frequency: 2x daily) for the period of 2 years
Other conditions:   narcolepsy
Other drugs taken:   provigil
  
Reported Results
Benefits:   helped to stay awake, without the side effects that I had when I used to take dexedrine, like jittery, agitation, dry mouth
Side effects:   There really weren't any side effects like those described above from dexedrine.
Comments:   100-150 mg a day, 100mg taken in the am, 50mg in pm (if needed) to help with daytime sleepiness, caused by narcolepsy. I usually do not take the afternoon dose unless I feel really tired and nervous about driving.

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Page last updated: 2008-11-02

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