WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.
Each capsule, for oral administration, contains:Codeine Phosphate, USP.
Butalbital, aspirin, caffeine, and codeine phosphate capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.
Evidence supporting the efficacy of butalbital, aspirin, caffeine, and codeine phosphate capsules is derived from 2 multi-clinic trials that compared patients with tension headache randomly assigned to 4 parallel treatments: butalbital, aspirin, caffeine, and codeine phosphate; codeine; butalbital, aspirin, and caffeine; and placebo. Response was assessed over the course of the first 4 hours of each of 2 distinct headaches, separated by at least 24 hours. The combination product of butalbital, aspirin, caffeine, and codeine phosphate, proved statistically significantly superior to each of its components and to placebo on measures of pain relief.
Evidence supporting the efficacy and safety of butalbital, aspirin, caffeine, and codeine phosphate capsules in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because codeine and butalbital are habit-forming and potentially abusable.
Media Articles Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)
Vitamin D deficiency increases risk of chronic headache
Source: Headache / Migraine News From Medical News Today [2017.01.04]
Vitamin D deficiency may increase the risk of chronic headache, according to a new study from the University of Eastern Finland. The findings were published in Scientific Reports.
Source: MedicineNet Dehydration Specialty [2016.11.30]
Title: Headache Remedies
Category: Diseases and Conditions
Created: 4/12/2016 12:00:00 AM
Last Editorial Review: 11/30/2016 12:00:00 AM
Visits to pediatric emergency departments for headache pain in children are on the rise
Source: Headache / Migraine News From Medical News Today [2016.10.24]
At 1 hospital, rates of emergency department visits and subsequent hospital admission doubled over a 7-year period.
Can You Blame Your Headaches on Your Thyroid?
Source: MedicineNet Hypothyroidism Specialty [2016.09.30]
Title: Can You Blame Your Headaches on Your Thyroid?
Category: Health News
Created: 9/29/2016 12:00:00 AM
Last Editorial Review: 9/30/2016 12:00:00 AM
Headaches and Menopause: What's the Connection?
Source: Headache / Migraine News From Medical News Today [2016.09.29]
Headaches are among the symptoms some women report during menopause. Learn more about what causes them, what other symptoms occur, and treatment options.
Published Studies Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)
Comparison of butorphanol nasal spray and fiorinal with codeine in the treatment of migraine. [1998.07]
Butorphanol tartrate is a synthetic mixed agonist-antagonist opioid analgesic. Its transnasal dosage form, which may be self-administered when the use of an opioid analgesic is appropriate, was previously shown to provide rapid relief of migraine pain... Butorphanol patients had more side effects, less improvement in digestive symptoms, and less improvement in functional ability than Fiorinal with Codeine patients.
Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. 
The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study...
Page last updated: 2017-01-04