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Butalbital, Aspirin, Caffeine, and Codeine (Codeine Phosphate / Butalbital / Caffeine / Aspirin) - Summary

 
 



WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE

Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.

 

SUMMARY

Each capsule, for oral administration, contains:Codeine Phosphate, USP.

Butalbital, aspirin, caffeine, and codeine phosphate capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.
Evidence supporting the efficacy of butalbital, aspirin, caffeine, and codeine phosphate capsules is derived from 2 multi-clinic trials that compared patients with tension headache randomly assigned to 4 parallel treatments: butalbital, aspirin, caffeine, and codeine phosphate; codeine; butalbital, aspirin, and caffeine; and placebo. Response was assessed over the course of the first 4 hours of each of 2 distinct headaches, separated by at least 24 hours. The combination product of butalbital, aspirin, caffeine, and codeine phosphate, proved statistically significantly superior to each of its components and to placebo on measures of pain relief.

Evidence supporting the efficacy and safety of butalbital, aspirin, caffeine, and codeine phosphate capsules in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because codeine and butalbital are habit-forming and potentially abusable.


See all Butalbital, Aspirin, Caffeine, and Codeine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Telemedicine May Work for Headache Visits (CME/CE)
Source: MedPage Today Neurology [2017.06.15]
(MedPage Today) -- Norwegian trial shows no differences between traditional, telemedicine consultations

Video Call May Be as Good as Doctor Visit for Headache
Source: MedicineNet Headache Specialty [2017.06.15]
Title: Video Call May Be as Good as Doctor Visit for Headache
Category: Health News
Created: 6/14/2017 12:00:00 AM
Last Editorial Review: 6/15/2017 12:00:00 AM

Headache
Source: MedicineNet Aches, Pain, Fever Specialty [2017.06.08]
Title: Headache
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 6/8/2017 12:00:00 AM

Dehydration headaches: Signs, treatment, and prevention
Source: Headache / Migraine News From Medical News Today [2017.05.19]
Headaches are a common cause of pain but what is a dehydration headache? Learn about the symptoms, causes, and how to treat a dehydration headache.

What does a headache behind the ear mean? Signs, causes, and treatments
Source: Arthritis / Rheumatology News From Medical News Today [2017.05.15]
A headache behind the ear can be caused by a number of things, including dental problems, nerve injury, and infection. Learn more in this article.

more news >>

Published Studies Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Comparison of butorphanol nasal spray and fiorinal with codeine in the treatment of migraine. [1998.07]
Butorphanol tartrate is a synthetic mixed agonist-antagonist opioid analgesic. Its transnasal dosage form, which may be self-administered when the use of an opioid analgesic is appropriate, was previously shown to provide rapid relief of migraine pain... Butorphanol patients had more side effects, less improvement in digestive symptoms, and less improvement in functional ability than Fiorinal with Codeine patients.

Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. [1988]
The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study...

more studies >>


Page last updated: 2017-06-15

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