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Butalbital, Aspirin, Caffeine, and Codeine (Codeine Phosphate / Butalbital / Caffeine / Aspirin) - Summary

 
 



WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE

Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.

 

SUMMARY

Each capsule, for oral administration, contains:Codeine Phosphate, USP.

Butalbital, aspirin, caffeine, and codeine phosphate capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.
Evidence supporting the efficacy of butalbital, aspirin, caffeine, and codeine phosphate capsules is derived from 2 multi-clinic trials that compared patients with tension headache randomly assigned to 4 parallel treatments: butalbital, aspirin, caffeine, and codeine phosphate; codeine; butalbital, aspirin, and caffeine; and placebo. Response was assessed over the course of the first 4 hours of each of 2 distinct headaches, separated by at least 24 hours. The combination product of butalbital, aspirin, caffeine, and codeine phosphate, proved statistically significantly superior to each of its components and to placebo on measures of pain relief.

Evidence supporting the efficacy and safety of butalbital, aspirin, caffeine, and codeine phosphate capsules in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because codeine and butalbital are habit-forming and potentially abusable.


See all Butalbital, Aspirin, Caffeine, and Codeine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Severe Headache During Pregnancy May Signal Trouble
Source: MedicineNet Headache Specialty [2015.08.21]
Title: Severe Headache During Pregnancy May Signal Trouble
Category: Health News
Created: 8/20/2015 12:00:00 AM
Last Editorial Review: 8/21/2015 12:00:00 AM

Severe headache in pregnant women: When to worry
Source: Headache / Migraine News From Medical News Today [2015.08.20]
New findings by Montefiore and Einstein researchers offer first clinical recommendationsIf a pregnant woman with high blood pressure and no history of headache suddenly develops a headache that...

Health Tip: Soothing a Tension Headache
Source: MedicineNet Headache Specialty [2015.08.18]
Title: Health Tip: Soothing a Tension Headache
Category: Health News
Created: 8/18/2015 12:00:00 AM
Last Editorial Review: 8/18/2015 12:00:00 AM

More evidence that kids' headaches increase at back-to-school time
Source: Anxiety / Stress News From Medical News Today [2015.08.17]
Findings from Nationwide Children's Hospital physicians demonstrate that headaches increase in fall in children, a trend that may be due to back-to-school changes in stress, routines and sleep.

Headaches Are Common in Kids, Teens
Source: MedicineNet Headache Specialty [2015.08.17]
Title: Headaches Are Common in Kids, Teens
Category: Health News
Created: 8/14/2015 12:00:00 AM
Last Editorial Review: 8/17/2015 12:00:00 AM

more news >>

Published Studies Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Comparison of butorphanol nasal spray and fiorinal with codeine in the treatment of migraine. [1998.07]
Butorphanol tartrate is a synthetic mixed agonist-antagonist opioid analgesic. Its transnasal dosage form, which may be self-administered when the use of an opioid analgesic is appropriate, was previously shown to provide rapid relief of migraine pain... Butorphanol patients had more side effects, less improvement in digestive symptoms, and less improvement in functional ability than Fiorinal with Codeine patients.

Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. [1988]
The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study...

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Page last updated: 2015-08-21

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