WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.
Each capsule, for oral administration, contains:Codeine Phosphate, USP.
Butalbital, aspirin, caffeine, and codeine phosphate capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.
Evidence supporting the efficacy of butalbital, aspirin, caffeine, and codeine phosphate capsules is derived from 2 multi-clinic trials that compared patients with tension headache randomly assigned to 4 parallel treatments: butalbital, aspirin, caffeine, and codeine phosphate; codeine; butalbital, aspirin, and caffeine; and placebo. Response was assessed over the course of the first 4 hours of each of 2 distinct headaches, separated by at least 24 hours. The combination product of butalbital, aspirin, caffeine, and codeine phosphate, proved statistically significantly superior to each of its components and to placebo on measures of pain relief.
Evidence supporting the efficacy and safety of butalbital, aspirin, caffeine, and codeine phosphate capsules in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because codeine and butalbital are habit-forming and potentially abusable.
Media Articles Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)
FDA Approves Device to Help Curb Cluster Headaches
Source: MedicineNet Headache Specialty [2017.04.20]
Title: FDA Approves Device to Help Curb Cluster Headaches
Category: Health News
Created: 4/19/2017 12:00:00 AM
Last Editorial Review: 4/20/2017 12:00:00 AM
FDA Approves Vagus Stimulation Device for Cluster Headache
Source: Medscape NeurologyHeadlines [2017.04.18]
The FDA has approved a noninvasive vagus nerve stimulation device for the treatment of pain from cluster headache in adults.
FDA Clears Noninvasive Device for Episodic Cluster Headache
Source: MedPage Today Neurology [2017.04.18]
(MedPage Today) -- VNS device not approved for chronic cluster headache
Occipital Neuralgia (A Type of Headache)
Source: MedicineNet Headache Specialty [2017.03.15]
Title: Occipital Neuralgia (A Type of Headache)
Category: Diseases and Conditions
Created: 3/11/2016 12:00:00 AM
Last Editorial Review: 3/15/2017 12:00:00 AM
Source: MedicineNet Antiphospholipid Syndrome Specialty [2017.03.13]
Title: Migraine Headache
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 3/13/2017 12:00:00 AM
Published Studies Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)
Comparison of butorphanol nasal spray and fiorinal with codeine in the treatment of migraine. [1998.07]
Butorphanol tartrate is a synthetic mixed agonist-antagonist opioid analgesic. Its transnasal dosage form, which may be self-administered when the use of an opioid analgesic is appropriate, was previously shown to provide rapid relief of migraine pain... Butorphanol patients had more side effects, less improvement in digestive symptoms, and less improvement in functional ability than Fiorinal with Codeine patients.
Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. 
The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study...
Page last updated: 2017-04-20