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Butalbital, Aspirin, Caffeine, and Codeine (Codeine Phosphate / Butalbital / Caffeine / Aspirin) - Summary

 
 



SUMMARY

Butalbital, Aspirin, Caffeine, and Codeine Phosphate Capsules, USP
C-III
Revised: January 2007
Rx only

Each capsule, for oral administration, contains:Codeine Phosphate, USP.

Butalbital, aspirin, caffeine, and codeine phosphate capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.
Evidence supporting the efficacy of butalbital, aspirin, caffeine, and codeine phosphate capsules is derived from 2 multi-clinic trials that compared patients with tension headache randomly assigned to 4 parallel treatments: butalbital, aspirin, caffeine, and codeine phosphate; codeine; butalbital, aspirin, and caffeine; and placebo. Response was assessed over the course of the first 4 hours of each of 2 distinct headaches, separated by at least 24 hours. The combination product of butalbital, aspirin, caffeine, and codeine phosphate, proved statistically significantly superior to each of its components and to placebo on measures of pain relief.

Evidence supporting the efficacy and safety of butalbital, aspirin, caffeine, and codeine phosphate capsules in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because codeine and butalbital are habit-forming and potentially abusable.


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NEWS HIGHLIGHTS

Media Articles Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Headache
Source: MedicineNet Brain Aneurysm Specialty [2015.03.20]
Title: Headache
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 3/20/2015 12:00:00 AM

Small clinical study finds electroCore's non-invasive vagus nerve stimulation is effective in treating cluster headaches
Source: Headache / Migraine News From Medical News Today [2015.03.05]
A twelve-month open-label study in the March issue of the journal Neurology, reports that electroCore's non-invasive Vagus Nerve stimulation (nVNS) device, gammaCore, is practical and effective as...

Headache Pictures Slideshow: Surprising Headache and Migraine Triggers
Source: MedicineNet Brain Tumor Specialty [2015.03.05]
Title: Headache Pictures Slideshow: Surprising Headache and Migraine Triggers
Category: Slideshows
Created: 5/18/2009 12:00:00 AM
Last Editorial Review: 3/5/2015 12:00:00 AM

Headaches Quiz: Test Your Headache Pain IQ
Source: MedicineNet codeine Specialty [2015.02.23]
Title: Headaches Quiz: Test Your Headache Pain IQ
Category: MedicineNet Quiz
Created: 9/28/2010 11:09:00 AM
Last Editorial Review: 2/23/2015 12:22:07 PM

Cluster Headaches
Source: MedicineNet Brain Aneurysm Specialty [2015.02.02]
Title: Cluster Headaches
Category: Diseases and Conditions
Created: 2/4/2005 12:00:00 AM
Last Editorial Review: 2/2/2015 12:00:00 AM

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Published Studies Related to Butalbital, Aspirin, Caffeine, and Codeine (Codeine / Butalbital / Caffeine / Aspirin)

Comparison of butorphanol nasal spray and fiorinal with codeine in the treatment of migraine. [1998.07]
Butorphanol tartrate is a synthetic mixed agonist-antagonist opioid analgesic. Its transnasal dosage form, which may be self-administered when the use of an opioid analgesic is appropriate, was previously shown to provide rapid relief of migraine pain... Butorphanol patients had more side effects, less improvement in digestive symptoms, and less improvement in functional ability than Fiorinal with Codeine patients.

Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. [1988]
The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study...

more studies >>


Page last updated: 2015-03-20

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