Buspar (Buspirone Hydrochloride) - Summary

BUSPAR SUMMARY

BuSpar^®
(buspirone HCl, USP)

BuSpar^® (buspirone hydrochloride tablets, USP) is an antianxiety agent that is not chemically or pharmacologically related to the ben-zodiazepines, barbiturates, or other sedative/anxiolytic drugs.

BuSpar (Buspirone HCl) is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

See all Buspar indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Buspar (Buspirone)

Kava Successfully Treats Anxiety In World First Clinical Trial
Source: Anxiety / Stress News From Medical News Today [2013.05.15]
A world-first completed clinical study by an Australian team has found Kava, a medicinal South Pacific plant, significantly reduced the symptoms of people suffering anxiety...

Emotional Strategies Can Influence Anxiety
Source: Anxiety / Stress News From Medical News Today [2013.05.14]
When trouble approaches, what do you do? Run for the hills? Hide? Pretend it isn't there? Or do you focus on the promise of rain in those looming dark clouds? New research suggests that the way you regulate your emotions, in bad times and in good, can influence whether - or how much - you suffer from anxiety. The study appears in the journal Emotion...

Anxiety And Stress Benefits From Exercise, Even When Forced
Source: Anxiety / Stress News From Medical News Today [2013.04.29]
Being forced to exercise may still help reduce anxiety and depression just as exercising voluntarily does, according to a new study by researchers at the University of Colorado Boulder. Past studies have shown that people who exercise are more protected against stress-related disorders. And scientists know that the perception of control can benefit a person's mental health...

Reducing Pain And Anxiety Among Pediatric Patients Using Robot Therapy
Source: IT / Internet / E-mail News From Medical News Today [2013.04.07]
Pet therapy can help patients cope with the pain, stress, and emotional effects of a serious illness, but access to a companion animal is not always possible. Robotic animals may offer the same benefits, as explored in a fascinating study presented in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers...

Acupuncture Improves Memory, Test Performance, And Reduces Anxiety
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2013.03.09]
A new study shows that acupuncture improves memory, test performance, and reduces anxiety. The study will appear in an upcoming edition of The Journal of Acupuncture and Meridian Studies. Dr. Jason Bussell, PhD, conducted an experiment with 90 undergraduate students. Half the students received acupuncture and half did not; and the placebo effect was controlled...

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Published Studies Related to Buspar (Buspirone)

Evaluation of buspirone for relapse-prevention in adults with cocaine dependence: an efficacy trial conducted in the real world. [2012]
Cocaine dependence is a significant public health problem for which there are currently no FDA-approved medications.Unique aspects of the study include conducting an efficacy trial in community treatment programs, a two-stage process to efficiently evaluate buspirone, and an evaluation of mediators by which buspirone might exert a beneficial effect on relapse prevention.

A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression. [2011]
To compare the efficacy and safety of augmenting paroxetine with risperidone, buspirone, valproate, trazodone, or thyroid hormone in patients with treatment-resistant depression (TRD), 225 patients with retrospectively and/or prospectively identified stage II TRD were randomly assigned to receive an 8-week treatment of paroxetine 20 mg/d augmented with risperidone 2 mg/d (n = 45), sodium valproate 600 mg/d (n = 39), buspirone 30 mg/d (n = 46), trazodone 100 mg/d (n = 47), or thyroid hormone 80 mg/d (n = 48)...

A double-blind, randomized, and placebo-controlled trial of buspirone added to risperidone in patients with chronic schizophrenia. [2010.12]
OBJECTIVE: The role of partial agonism at 5-HT1A receptors in general and of buspirone in particular remains unclear in the treatment of negative symptoms of schizophrenia. This study was designed to investigate the effect of buspirone added to risperidone as augmentation therapy in patients with chronic schizophrenia and prominent negative symptoms in a double-blind randomized clinical trial... CONCLUSIONS: The present study indicates buspirone as a potential adjunctive treatment strategy for the treatment of schizophrenia, in particular, negative symptoms. Nevertheless, results of larger controlled trials are needed before recommendation for a broad clinical application can be made. This trial is registered with the Iranian Clinical Trials Registry (IRCT138712051556N8).

Buspirone versus methylphenidate in the treatment of attention deficit hyperactivity disorder: a double-blind and randomized trial. [2010.12]
The efficacy and side effects of buspirone compared with methylphenidate (MPH) in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). A total of 34 children with ADHD as defined by DSM-IV-TR were randomized to buspirone or methylphenidate dosed on weight-adjusted basis at buspirone (0.5 mg/kg/day) and methylphenidate (0.3-1 mg/kg/day) for a 6-week double-blind clinical trial...

Randomized, single-blind, trial of sertraline and buspirone for treatment of elderly patients with generalized anxiety disorder. [2010.04]
AIM: Generalized anxiety disorder (GAD) in elderly people is common, but few systematic studies regarding the best treatments have been performed. The aim of the present study was to evaluate the efficacy and safety of sertraline and buspirone in the treatment of elderly patients with GAD... CONCLUSION: Both sertraline and buspirone appear to be efficacious and well tolerated in the treatment of GAD in elderly patients. Further studies with larger sample size, evaluating the effect of medical illness, cognitive impairment, depression, and combined therapy with support and psychotherapy are needed.

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Clinical Trials Related to Buspar (Buspirone)

Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting and Fed Conditions [Completed]

Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting Conditions [Completed]

Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET [Recruiting]
The objective of the present study is to use positron emission tomography brain imaging to investigate D3 occupancy of buspirone, an FDA-approved anxiolytic which acts as a serotonin partial agonist but has recently been identified as a D3 antagonist. It is hypothesized that clinically relevant doses of buspirone will occupy the D3 receptor.

Buspirone in the Treatment of 2-6 Year Old Children With Autistic Disorder [Recruiting]
The purpose of this study is to evaluate the effects of twice-daily oral buspirone on core features of autism in autistic children aged 2-6 years as measured by the change from baseline in the Autism Diagnostic Observation Schedule (ADOS) Composite Total scores compared to placebo at 6 months.

Double-blind Trial of Buspirone for the Treatment of Anxiety in Youth With Autism Spectrum Disorders [Recruiting]
The main objective of this exploratory 8 week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders. The study results will be used to generate hypotheses for a larger randomized controlled clinical trial with explicit hypotheses and sufficient statistical power.

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Reports of Suspected Buspar (Buspirone) Side Effects

Drug Ineffective (13),  Rash (9),  Insomnia (9),  Suicide Attempt (9),  Hypoglycaemia (8),  Weight Increased (8),  Intentional Overdose (7),  Convulsion (7),  Anxiety (7),  Agitation (6), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Buspar review by 40 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Anxiety
Dosage & duration:		10 mg taken 1/2 tablet twice a day for the period of 1 year
Other conditions:		n/a
Other drugs taken:		Inderal
		Reported Results
Benefits:		I lived in a constant state of panic (shortness of breath, rapid heart rate, flushed feeling), and this medication completely erased all these symptoms. I can now think clearly and make rational decisions. I chose to stay on this very low dose and take an Ativan on the rare occasion a panic attack breaks through.
Side effects:		I feel a little drowsy and slightly lightheaded for about 30 minutes after taking medicine, but it is not severe enough to interfere with my work or life.
Comments:		I take half a 10 mg tablet in the morning and the other half in the late afternoon.

Buspar review by 73 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Anxiety
Dosage & duration:		1/2 of 15 mg tablet taken ocassionaly for the period of Several years
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		It did help to relieve my anxiety, but sometimes I had to take a full tablet rather than 1/2. It did enable me to ably cope with occasions where I otherwise would have been nervous wreck. I can honestly say that it helped me.
Side effects:		I didn't have any.
Comments:		I only took it sporadically whenever needed. I only used it when I needed calming down when I was in a situation that I wouldn't have have been able to cope with.

Buspar review by 73 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Anxiety
Dosage & duration:		1/2 of 15 mg tablet taken ocassionaly for the period of Several years
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		It did help to relieve my anxiety, but sometimes I had to take a full tablet rather than 1/2. It did enable me to ably cope with occasions where I otherwise would have been nervous wreck. I can honestly say that it helped me.
Side effects:		I didn't have any.
Comments:		I only took it sporadically whenever needed. I only used it when I needed calming down when I was in a situation that I wouldn't have have been able to cope with.