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Buspar (Buspirone Hydrochloride) - Summary

 
 



BUSPAR SUMMARY

BuSpar®
(buspirone HCl, USP)

BuSpar® (buspirone hydrochloride tablets, USP) is an antianxiety agent that is not chemically or pharmacologically related to the ben-zodiazepines, barbiturates, or other sedative/anxiolytic drugs.

BuSpar (Buspirone HCl) is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
See all Buspar indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Buspar (Buspirone)

Boosting natural brain opioids may be a better way to treat anxiety: Research
Source: Anxiety / Stress News From Medical News Today [2017.03.24]
Published in Nature Communications by University of Sydney scholars, the findings suggest medications that boost the effect of natural brain opioids might be a better way to reduce anxiety than...

Anxiety Therapy Better for Depression Than CBT?
Source: Medscape Psychiatry & Mental Health Headlines [2017.03.21]
Metacognitive therapy, a psychotherapeutic approach targeting rumination and negative thought processes, has a large effect size when used to treat depression and may offer an alternative to CBT.
Medscape Medical News

Combining opioids with anti-anxiety medicines linked to greater risk of overdose
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2017.03.16]
Taking opioids (strong prescription painkillers) together with benzodiazepines (widely used to treat anxiety and sleep problems) is associated with greater risk of opioid overdose, finds a study in...

Low levels of 'anti-anxiety' hormone linked to postpartum depression
Source: Depression News From Medical News Today [2017.03.16]
In a small-scale study of women with previously diagnosed mood disorders, Johns Hopkins researchers report that lower levels of the hormone allopregnanolone in the second trimester of pregnancy...

Component of marijuana may help treat anxiety and substance abuse disorders
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2017.03.09]
Cannabidiol, a major component of cannabis or marijuana, appears to have effects on emotion and emotional memory, which could be helpful for treating anxiety-related and substance abuse disorders.

more news >>

Published Studies Related to Buspar (Buspirone)

A randomized trial of concurrent smoking-cessation and substance use disorder treatment in stimulant-dependent smokers. [2014]
CONCLUSIONS: These results suggest that providing smoking-cessation treatment to

Evaluation of buspirone for relapse-prevention in adults with cocaine dependence: an efficacy trial conducted in the real world. [2012]
Cocaine dependence is a significant public health problem for which there are currently no FDA-approved medications.Unique aspects of the study include conducting an efficacy trial in community treatment programs, a two-stage process to efficiently evaluate buspirone, and an evaluation of mediators by which buspirone might exert a beneficial effect on relapse prevention.

A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression. [2011]
To compare the efficacy and safety of augmenting paroxetine with risperidone, buspirone, valproate, trazodone, or thyroid hormone in patients with treatment-resistant depression (TRD), 225 patients with retrospectively and/or prospectively identified stage II TRD were randomly assigned to receive an 8-week treatment of paroxetine 20 mg/d augmented with risperidone 2 mg/d (n = 45), sodium valproate 600 mg/d (n = 39), buspirone 30 mg/d (n = 46), trazodone 100 mg/d (n = 47), or thyroid hormone 80 mg/d (n = 48)...

A double-blind, randomized, and placebo-controlled trial of buspirone added to risperidone in patients with chronic schizophrenia. [2010.12]
OBJECTIVE: The role of partial agonism at 5-HT1A receptors in general and of buspirone in particular remains unclear in the treatment of negative symptoms of schizophrenia. This study was designed to investigate the effect of buspirone added to risperidone as augmentation therapy in patients with chronic schizophrenia and prominent negative symptoms in a double-blind randomized clinical trial... CONCLUSIONS: The present study indicates buspirone as a potential adjunctive treatment strategy for the treatment of schizophrenia, in particular, negative symptoms. Nevertheless, results of larger controlled trials are needed before recommendation for a broad clinical application can be made. This trial is registered with the Iranian Clinical Trials Registry (IRCT138712051556N8).

Buspirone versus methylphenidate in the treatment of attention deficit hyperactivity disorder: a double-blind and randomized trial. [2010.12]
The efficacy and side effects of buspirone compared with methylphenidate (MPH) in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). A total of 34 children with ADHD as defined by DSM-IV-TR were randomized to buspirone or methylphenidate dosed on weight-adjusted basis at buspirone (0.5 mg/kg/day) and methylphenidate (0.3-1 mg/kg/day) for a 6-week double-blind clinical trial...

more studies >>

Clinical Trials Related to Buspar (Buspirone)

Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET [Completed]
The objective of the present study is to use positron emission tomography brain imaging to investigate D3 occupancy of buspirone, an FDA-approved anxiolytic which acts as a serotonin partial agonist but has recently been identified as a D3 antagonist. It is hypothesized that clinically relevant doses of buspirone will occupy the D3 receptor.

Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting Conditions [Completed]

Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting and Fed Conditions [Completed]

Double-blind Trial of Buspirone for the Treatment of Anxiety in Youth With Autism Spectrum Disorders [Withdrawn]
The main objective of this exploratory 8 week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders. The study results will be used to generate hypotheses for a larger randomized controlled clinical trial with explicit hypotheses and sufficient statistical power.

Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence [Completed]
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon inpatient/residential discharge.

more trials >>

Reports of Suspected Buspar (Buspirone) Side Effects

Drug Ineffective (13)Rash (9)Insomnia (9)Suicide Attempt (9)Hypoglycaemia (8)Weight Increased (8)Intentional Overdose (7)Convulsion (7)Anxiety (7)Agitation (6)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Buspar has an overall score of 8.75. The effectiveness score is 8.50 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Buspar review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   10 mg taken 1/2 tablet twice a day for the period of 1 year
Other conditions:   n/a
Other drugs taken:   Inderal
  
Reported Results
Benefits:   I lived in a constant state of panic (shortness of breath, rapid heart rate, flushed feeling), and this medication completely erased all these symptoms. I can now think clearly and make rational decisions. I chose to stay on this very low dose and take an Ativan on the rare occasion a panic attack breaks through.
Side effects:   I feel a little drowsy and slightly lightheaded for about 30 minutes after taking medicine, but it is not severe enough to interfere with my work or life.
Comments:   I take half a 10 mg tablet in the morning and the other half in the late afternoon.

 

Buspar review by 73 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   1/2 of 15 mg tablet taken ocassionaly for the period of Several years
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   It did help to relieve my anxiety, but sometimes I had to take a full tablet rather than 1/2. It did enable me to ably cope with occasions where I otherwise would have been nervous wreck. I can honestly say that it helped me.
Side effects:   I didn't have any.
Comments:   I only took it sporadically whenever needed. I only used it when I needed calming down when I was in a situation that I wouldn't have have been able to cope with.

 

Buspar review by 73 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   1/2 of 15 mg tablet taken ocassionaly for the period of Several years
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   It did help to relieve my anxiety, but sometimes I had to take a full tablet rather than 1/2. It did enable me to ably cope with occasions where I otherwise would have been nervous wreck. I can honestly say that it helped me.
Side effects:   I didn't have any.
Comments:   I only took it sporadically whenever needed. I only used it when I needed calming down when I was in a situation that I wouldn't have have been able to cope with.

See all Buspar reviews / ratings >>

Page last updated: 2017-03-24

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