NEWS HIGHLIGHTSMedia Articles Related to Bupivacaine (Bupivacaine / Dextrose Subarachnoid)
New Data Support The Benefits Of EXPAREL For Postsurgical Analgesia Following Aesthetic Plastic Surgery Procedures
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2013.04.16]
Pacira Pharmaceuticals, Inc. (NASDAQ: PCRX) have announced results from EXCLAIM, its Phase 4 prospective, observational study to assess the use of EXPAREL® (bupivacaine liposome injectable suspension) for postsurgical analgesia in patients undergoing four common plastic surgery procedures...
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Lower Rates Of Complications In Hip And Knee Replacement Using Regional Anesthesia Technique
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.03]
A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery...
General Anesthesia Not Linked to Raised Risk for Dementia
Source: MedicineNet Dementia Specialty [2013.05.02]
Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced
Source: Pain / Anesthetics News From Medical News Today [2013.04.22]
When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound...
Published Studies Related to Bupivacaine (Bupivacaine / Dextrose Subarachnoid)
Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and
intrathecal morphine improves quality of pain control after total knee
arthroplasty: a randomized double-blind placebo controlled clinical trial. [2012]
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal
Bupivacaine extended-release liposome injection exhibits a favorable cardiac
safety profile. [2012]
novel formulation of bupivacaine... CONCLUSIONS: A focused assessment of ECG data from a phase 2 study and cardiac
Analgesic control and functional outcome after knee arthroscopy: results of a
randomized double-blinded trial comparing a hyaluronic acid supplement with
bupivacaine. [2012]
functional outcomes after knee arthroscopy... CONCLUSIONS: There was no benefit of HA injection immediately at the end of knee
A two-year observational study assessing the safety of DepoFoam bupivacaine after
augmentation mammaplasty. [2012]
examination with respect to the integrity of the breast implants... CONCLUSIONS: At a two-year follow-up assessment, DepoFoam bupivacaine was not
The efficacy and safety of DepoFoam bupivacaine in patients undergoing bilateral,
cosmetic, submuscular augmentation mammaplasty: a randomized, double-blind,
active-control study. [2012]
augmentation mammaplasty under general anesthesia... CONCLUSIONS: DepoFoam bupivacaine trended toward benefit versus bupivacaine HCl
Clinical Trials Related to Bupivacaine (Bupivacaine / Dextrose Subarachnoid)
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic [Completed]
Minimum Local Anesthetic Volume of Bupivacaine in Labour Epidurals [Completed]
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the
most commonly used drugs for that purpose. The efficacy of a certain medication injected
epidurally depends on the dose that is given. A certain dose can be administered in different
concentrations, which will consequently mean different volumes. Our hypothesis is that for
each concentration of a certain drug, there has to be a minimum effective volume that will be
associated with the best possible performance of the drug. This study is being conducted to
find the minimum volume of bupivacaine (a local anesthetic) that produces successful
analgesia in 95% of patients in labor.
Ropivacaine Versus Bupivacaine for Spinal Anaesthesia in Patients Undergoing Unilateral Lower Limb Surgery [Completed]
The purpose of this study is to compare the efficacy, duration of motor block until return to
normal function in the non-operated leg after the start of injection, of ropivacaine 5 mg/ml
and bupivacaine 5 mg/ml when used for spinal anaesthesia in patients undergoing unilateral
lower limb surgery.
Bupivacaine Effectiveness and Safety in SABER⢠Trial [Recruiting]
This is a research study testing SABER™-Bupivacaine (an experimental pain-relieving
medication). SABER™-Bupivacaine is designed to continuously deliver bupivacaine, a common
local anesthetic, for a few days in order to treat local post-surgical pain.
The purpose of this study is to investigate safety (side effects) associated with the use of
SABER™-Bupivacaine and how well it works in reducing pain and opioid-related side effects
following various kinds of abdominal surgeries.
Epidural Fentanyl-bupivacaine Versus Clonidine-bupivacaine for Breakthrough Pain in Advanced Labor [Not yet recruiting]
Epidural analgesia is widely regarding as the most effective analgesic strategy for labor
pain. Modern practice is to utilize dilute local anesthetics as a continuous infusion along
with an opioid, e. g., our common "recipe" of 12 ml/hr of 0. 0625% bupivacaine with 2
micrograms/ml fentanyl, after the initial dose to maintain patient comfort until delivery.
This dose of the infusion often provides adequate comfort without interfering with the
mobility of the patient and her ability to effectively push during delivery. However, this
low dose epidural infusion strategy often results in recurrence of pain after an initial
pain free period.
This breakthrough pain is treated by administering small boluses of analgesics via the
epidural catheter. The pain occurring in labor is initially of visceral origin and is
mediated by pain fibers originating from the low thoracic and upper lumbar segments of the
spinal cord. As labor progresses to the late first phase (also known as transitional stage),
pain sensations originating from the distension of the pelvic floor, vagina and perineum
adds a somatic component to labor pain. This type of breakthrough pain is often difficult to
treat.
Although requests from patients to alleviate late stage breakthrough pain are common, no one
knows the most effective strategy for pain management in this stage of labor. This study is
designed to compare the efficacy of two treatments for controlling late first stage
breakthrough pain during labor with an epidural infusion in place: clonidine-bupivacaine
versus fentanyl-bupivacaine.
Women who have labor epidural analgesia in place will be enrolled to be randomized if and
when they present with breakthrough pain in the late first stage or second stage of labor
(⥠8 cm dilated). They will receive 8 ml of a solution containing 10 mg bupivacaine and 75
micrograms of either fentanyl (an opioid or "narcotic") or clonidine (an "alpha-2 agonist
known to be effective as an epidural analgesic).
Pain relief, labor progress and outcome will be assessed to compare fentanyl versus
clonidine.
It is the hypothesis of this study that clonidine added to bupivacaine is a better analgesic
than fentanyl added to bupivacaine for breakthrough pain in advanced labor.
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