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Bumex (Bumetanide) - Summary

 

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WARNING

Bumex (bumetanide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs (see DOSAGE AND ADMINISTRATION).

 

BUMEX SUMMARY

BUMEX®
brand of
bumetanide
TABLETS

Bumex® (bumetanide) is a loop diuretic, available as scored tablets, 0.5 mg (light green), 1 mg (yellow) and 2 mg (peach) for oral administration; each tablet also contains lactose, magnesium stearate, microcrystalline cellulose, cornstarch and talc, with the following dye systems: 0.5 mg—D&C Yellow No. 10 and FD&C Blue No. 1; 1 mg—D&C Yellow No. 10; 2 mg—red iron oxide.

Bumex is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.

Almost equal diuretic response occurs after oral and parenteral administration of bumetanide. Therefore, if impaired gastrointestinal absorption is suspected or oral administration is not practical, bumetanide should be given by the intramuscular or intravenous route.

Successful treatment with Bumex following instances of allergic reactions to furosemide suggests a lack of cross-sensitivity.

BUMEX NEWS HIGHLIGHTS

Published Studies Related to Bumex (Bumetanide)

Loop Diuretics Increase Bone Turnover and Decrease BMD in Osteopenic Postmenopausal Women: Results From a Randomized Controlled Study With Bumetanide. [2006.01]

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. [2008.02]

Detection of bumetanide in an over-the-counter dietary supplement. [2007.11]

Bumetanide administration attenuated traumatic brain injury through IL-1 overexpression. [2007.06]

more>>

Clinical Trials Related to Bumex (Bumetanide)

Bumetanide vs. Furosemide in Heart Failure [Not yet recruiting]

Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension [Completed]

more>>

Page last updated: 2008-06-22

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