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Bumetanide (Bumetanide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The most frequent clinical adverse reactions considered probably or possibly related to bumetanide are muscle cramps (seen in 1.1% of treated patients), dizziness (1.1%), hypotension (0.8%), headache (0.6%), nausea (0.6%), and encephalopathy (in patients with preexisting liver disease) (0.6%). One or more of these adverse reactions have been reported in approximately 4.1% of bumetanide-treated patients.

Less frequent clinical adverse reactions to bumetanide are impaired hearing (0.5%), pruritus (0.4%), electrocardiogram changes (0.4%), weakness (0.2%), hives (0.2%), abdominal pain (0.2%), arthritic pain (0.2%), musculoskeletal pain (0.2%), rash (0.2%) and vomiting (0.2%). One or more of these adverse reactions have been reported in approximately 2.9% of bumetanide-treated patients.

Other clinical adverse reactions, which have each occurred in approximately 0.1% of patients, are vertigo, chest pain, ear discomfort, fatigue, dehydration, sweating, hyperventilation, dry mouth, upset stomach, renal failure, asterixis, itching, nipple tenderness, diarrhea, premature ejaculation and difficulty maintaining an erection.

Laboratory abnormalities reported have included hyperuricemia (in 18.4% of patients tested), hypochloremia (14.9%), hypokalemia (14.7%), azotemia (10.6%), hyponatremia (9.2%), increased serum creatinine (7.4%), hyperglycemia (6.6%), and variations in phosphorus (4.5%), CO2 content (4.3%), bicarbonate (3.1%) and calcium (2.4%). Although manifestations of the pharmacologic action of bumetanide, these conditions may become more pronounced by intensive therapy.

Also reported have been thrombocytopenia (0.2%) and deviations in hemoglobin (0.8%), prothrombin time (0.8%), hematocrit (0.6%), WBC (0.3%) and differential counts (0.1%). There have been rare spontaneous reports of thrombocytopenia from postmarketing experience.

Diuresis induced by bumetanide may also rarely be accompanied by changes in LDH (1%), total serum bilirubin (0.8%), serum proteins (0.7%), SGOT (0.6%), SGPT (0.5%), alkaline phosphatase (0.4%), cholesterol (0.4%) and creatinine clearance (0.3%). Increases in urinary glucose (0.7%) and urinary protein (0.3%) have also been seen.



REPORTS OF SUSPECTED BUMETANIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Bumetanide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Bumetanide side effects / adverse reactions in 70 year old male

Reported by a physician from France on 2011-10-04

Patient: 70 year old male

Reactions: Bronchospasm, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Suspect drug(s):
Bumetanide
    Dosage: ;iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-30
    End date: 2010-11-03

Eupressyl (Urapidil)
    Dosage: ;iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-14
    End date: 2010-11-21

Claventin (Claventin /00973701/)
    Dosage: 10 gm; ;iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-29
    End date: 2010-11-12

Doribax
    Dosage: 1 gm;qd;po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-11-15
    End date: 2010-11-26

Orgaran
    Dosage: ; sc
    Start date: 2010-10-25
    End date: 2011-01-26

Alprazolam
    Dosage: 0.25 mg; qd;po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-11-15
    End date: 2010-12-06

Bactrim
    Dosage: 400 mg; ;iv
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-29
    End date: 2010-11-06

Aldomet
    Dosage: ;po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-11-15
    End date: 2011-01-10

Furosemide
    Dosage: ;po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-14
    End date: 2011-01-17



Possible Bumetanide side effects / adverse reactions in 71 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-21

Patient: 71 year old female

Reactions: Ventricular Extrasystoles, Dyspnoea, Eye Oedema, Drug Interaction, Mental Impairment, Malaise, Diarrhoea, Blood Electrolytes Abnormal, Visual Impairment, Oedema, Nasal Disorder, Blood Creatinine Increased

Suspect drug(s):
Lorazepam
    Indication: Product Used FOR Unknown Indication

Metolazone

Potassium Chloride
    Indication: Product Used FOR Unknown Indication

Folic Acid
    Indication: Product Used FOR Unknown Indication

Diltiazem HCL
    Indication: Product Used FOR Unknown Indication

Bumetanide
    Indication: Product Used FOR Unknown Indication

Spironolactone
    Indication: Product Used FOR Unknown Indication

Cetirizine HCL
    Indication: Product Used FOR Unknown Indication

Tikosyn
    Indication: Atrial Fibrillation

Latanoprost
    Indication: Product Used FOR Unknown Indication

Metoprolol Succinate
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Indication: Product Used FOR Unknown Indication



Possible Bumetanide side effects / adverse reactions in 71 year old female

Reported by a consumer/non-health professional from United States on 2011-10-24

Patient: 71 year old female

Reactions: Ventricular Extrasystoles, Dyspnoea, Eye Oedema, Drug Interaction, Mental Impairment, Malaise, Diarrhoea, Blood Electrolytes Abnormal, Visual Impairment, Oedema, Nasal Disorder, Blood Creatinine Increased

Suspect drug(s):
Folic Acid
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Cetirizine HCL
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Bumetanide
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Tikosyn
    Dosage: (df)
    Indication: Atrial Fibrillation

Spironolactone
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Potassium Chloride
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Metoprolol Succinate
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Diltiazem HCL
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Latanoprost
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Metolazone
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Lorazepam
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication



See index of all Bumetanide side effect reports >>

Drug label data at the top of this Page last updated: 2014-07-23

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