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Bromax (Brompheniramine Maleate) - Description and Clinical Pharmacology

 
 



DESCRIPTION

Each white, dye free, Bromax Tablet for oral administration contains:

Brompheniramine Maleate ..............  11 mg

Formulated in a specially prepared base which provides prolonged activity suitable for B.I.D. dosing.

Bromax Tablets contain ingredients of the following therapeutic class: Antihistamine.

Brompheniramine Maleate is 2-Pyridinepropanamine, Ī³-(4- bromophenyl)-N,N-dimethyl-, (±)-, (Z)-2-butenedioate (1:1) and has the following structural formula:

 C<sub>16</sub>H<sub>19</sub>BrN2 • C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>        M.W. 435.31

C16H19BrN2 • C4H4O4        M.W. 435.31

INACTIVE INGREDIENTS

Colloidal silicon dioxide, Eudragit, lactose monohydrate, magnesium stearate (veg.), methylcellulose, microcrystalline cellulose, povidone, silicified microcrystalline cellulose and stearic acid.

CLINICAL PHARMACOLOGY

Brompheniramine maleate is classified as an alkylamine antihistamine. This class is among the most active histamine antagonists and is generally effective in relatively low doses. Alkylamines cause a lesser degree of drowsiness and sedation than the phenothiazine and ethanolamine antihistamines and hence may be more suitable for daytime use. It should be noted however that patients taking alkylamine antihistamines may experience some degree of drowsiness and should be cautioned accordingly.

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