Media Articles Related to Brevital (Methohexital)
Concerns About Anesthesia's Impact On The Brain
Source: Pain / Anesthetics News From Medical News Today [2013.06.07]
As pediatric specialists become increasingly aware that surgical anesthesia may have lasting effects on the developing brains of young children, new research suggests the threat may also apply to adult brains...
Increasing Rates Of Emergency C-Section And Accompanying Emergency Anesthesia
Source: Pain / Anesthetics News From Medical News Today [2013.06.05]
There is an increasing need for safe emergency anaesthesia as cases of emergency Caesarean section (CS) continue to rise, said experts speaking at Euroanaesthesia, the annual congress of the European Society of Anaesthesiology (ESA)...
General Anesthesia Raises Dementia Risk Among Elderly Patients
Source: Pain / Anesthetics News From Medical News Today [2013.06.02]
Elderly patients who are exposed to general anesthesia have a 35% higher risk of developing dementia, researchers from INSERM and University of Bordeaux, France, reported at Euroanaesthesia, the annual congress of the European Society of Anaesthesiology (ESA)...
Faster Spinal Anesthesia For Cancer Patients At End Of Life
Source: Pain / Anesthetics News From Medical News Today [2013.05.29]
For patients with uncontrolled pain from terminal cancer, a new approach to calculating initial dosage may allow a quicker start of spinal analgesia - and less time in the hospital, according to a study in the June issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS)...
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Pain / Anesthetics News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Published Studies Related to Brevital (Methohexital)
The comparative hemodynamic effects of methohexital and remifentanil in electroconvulsive therapy. [2005.03]
Remifentanil is a short acting opioid frequently used to supplement general anesthesia for brief procedures. Narcotic agents are known for their ability to blunt autonomic responses to stimuli such as laryngoscopy and intubation and do not alter seizure threshold...
The comparative effects of sevoflurane and methohexital for electroconvulsive therapy. [2003.12]
The standard anesthetic agent for electroconvulsive therapy (ECT) has been methohexital... We conclude that, when indicated, sevoflurane could provide a suitable alternative treatment option to methohexital, but some limitations, including shortened seizure duration and potential side effects, should be kept in mind.
Seizure duration with remifentanil/methohexital vs. methohexital alone in middle-aged patients undergoing electroconvulsive therapy. [2003.10]
CONCLUSION: Substituting part of the methohexital dose with remifentanil is a useful anesthetic technique to prolong seizure duration in middle-aged patients requiring a 1.5-fold higher induction dose of methohexital than elderly patients, the only population studied to date for the combined use of methohexital and remifentanil in ECT.
A randomized comparison of propofol and methohexital as general anesthetics for vacuum abortion. [2003.09]
The objective of this study was to determine whether propofol and methohexital differ in their efficacy, acceptability, cost and side effects when used as the single anesthetic agent for inducing general anesthesia in first-trimester vacuum abortion... In our population of midwestern patients in a major urban area, propofol use had modest advantages over methohexital when used as single agents as judged by first recovery charge nurses, but patients found them equally acceptable.
Randomized clinical trial of propofol versus methohexital for procedural sedation during fracture and dislocation reduction in the emergency department. [2003.09]
Although methohexital has been well studied for use in emergency department (ED) procedural sedation (PS), propofol has been evaluated less extensively for ED use. OBJECTIVE: The authors hypothesized that there is no difference in the depth of sedation and the rate of respiratory depression (RD) between propofol and methohexital in PS during the reduction of fractures and dislocations in the ED... CONCLUSIONS: The authors were unable to detect a significant difference in the level of subclinical RD or the level of sedation by BIS between the two agents. The use of either agent seems to be safe in the ED.
Clinical Trials Related to Brevital (Methohexital)
Use of Ketamine vs Methohexital for Electroconvulsive Therapy (ECT) on Patient Recovery and Re-orientation Time [Recruiting]
Ketamine Anesthesia in Electroconvulsive Therapy [Recruiting]
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression [Recruiting]
Electroconvulsive therapy (ECT) is one of the most robust antidepressant treatments
available. However, there is the potential for significant acute and longer term adverse
cognitive effects with ECT and the antidepressant response requires multiple treatment
sessions, increasing risk of adverse effects. Further, antidepressant response to ECT is
often less than maximal and relapse is common. Growing preclinical and clinical evidence of
the rapid-acting antidepressant properties of the anesthetic agent ketamine suggests the use
of ketamine anesthesia as a strategy to increase rate of response and shorten treatment
course in the administration of ECT. In addition, preclinical and clinical evidence suggests
the potential of ketamine to decrease the adverse cognitive effects associated with ECT.
The investigators propose a pilot study to measure both acute therapeutic efficacy and
cognitive side effects of ECT using ketamine compared to methohexital in depressed patients.
The investigators will also explore other parameters of ECT such as seizure duration and
morphology, as well as hemodynamic and behavioral changes.
Comparison of Thiopental and Propofol as Anaesteticum During ECT [Recruiting]
Electroconvulsive therapy is the most effective treatment in severe depression and the
effect is related to the generalized seizure induced by the treatment. General anesthesia is
used during the treatment. Since only a brief period of unconsciousness is required
anesthetics with a rapid recovery profile are used.
Methohexital, a barbiturat, is internationally considered "the golden standard", bot other
short-acting anesthetics are used. In Denmark the most frequent used anestheticum for ECT is
Thiopental, a barbiturat, but also Propofol, a non-barbiturat, is used in many psychiatric
Several studies have shown that Propofol reduce seizure duration in comparison with
barbiturates. So far, no studies have demonstrated any clinical implications of the reduced
seiziure duration. However, these studies have included rather few patiens, most have been
retrospective, and in the only prospective study conducted, uni-lateral ECT was used.
The aim of this study is to compare the clinical effect of ECT in patients anesthesized with
either Propofol or Thiopental. The hypothesis is that the shorter duration of seizures found
with Propofol as anestheticum will increase the number of treatments needed to clinial
respons. Furthermore we want to study differences in EEG-relate parameters previously shown
to have prognostic value. Hospitalized patients with major depression, who is to be treated
with ECT, are randomized to anesthizia with either Thiopental or Propofol. They are rated
with Hamilton depression scale and BDI before treatment, after six treatments and when
treatment is concluded. When treatment is ended the patients are furthermore rated with MMSE
to evaluate their degree of cognitive impairment.