BOTOX SUMMARY
BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex is a sterile, vacuum-dried purified botulinum toxin type A, produced from fermentation of Hall strain
Clostridium botulinum
type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. The complex is dissolved in sterile sodium chloride solution containing Albumin (Human) and is sterile filtered (0.2 microns) prior to filling and vacuum-drying.
BOTOX® is indicated for the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia.
BOTOX® is indicated for the treatment of severe primary axillary hyperhidrosis that is inadequately managed with topical agents.
BOTOX® is indicated for the treatment of strabismus and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above.
The efficacy of BOTOX® treatment in deviations over 50 prism diopters, in restrictive strabismus, in Duane's syndrome with lateral rectus weakness, and in secondary strabismus caused by prior surgical over-recession of the antagonist has not been established. BOTOX® is ineffective in chronic paralytic strabismus except when used in conjunction with surgical repair to reduce antagonist contracture.
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NEWS HIGHLIGHTSMedia Articles Related to Botox (Botulinum Toxin Type A)
Botox Reveals New Wrinkle In Brain Communication
Source: Epilepsy News From Medical News Today [2013.05.06]
National Institutes of Health researchers used the popular anti-wrinkle agent Botox to discover a new and important role for a group of molecules that nerve cells use to quickly send messages. This novel role for the molecules, called SNARES, may be a missing piece that scientists have been searching for to fully understand how brain cells communicate under normal and disease conditions...
Botox Injections Can Make You Depressed
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2013.04.13]
Cosmetic injections to decrease crows' feet may actually leave people feeling depressed, a new small study reveals. The treatment uses the Botulinum toxin and reduces the strength of the eye muscles which aid in the face's overall formation of a smile...
Botox Approved for Overactive Bladder
Source: MedicineNet Overactive Bladder Specialty [2013.01.23]
Title: Botox Approved for Overactive Bladder
Category: Health News
Created: 1/22/2013 12:35:00 PM
Last Editorial Review: 1/23/2013 12:00:00 AM
Botox
Source: MedicineNet Botulism Specialty [2012.07.08]
Title: Botox
Category: Procedures and Tests
Created: 1/31/2005 6:50:00 AM
Last Editorial Review: 7/8/2012 12:00:00 AM
Botox May Ease Tremors in Multiple Sclerosis Patients
Source: MedicineNet Wrinkles Specialty [2012.07.03]
Title: Botox May Ease Tremors in Multiple Sclerosis Patients
Category: Health News
Created: 7/2/2012 6:05:00 PM
Last Editorial Review: 7/3/2012 12:00:00 AM
Published Studies Related to Botox (Botulinum Toxin Type A)
Anticholinergic therapy vs. onabotulinumtoxina for urgency urinary incontinence. [2012]
therapy are needed... CONCLUSIONS: Oral anticholinergic therapy and onabotulinumtoxinA by injection
Botulinum toxin effects on gasatrocnemius strength and plantar pressure in
diabetics with peripheral neuropathy and forefoot ulceration. [2012]
gastrocnemius-soleus muscles to reduce muscle strength and plantar pressure... CONCLUSION: There were no adverse events associated with the Botox® injections.
Vandetanib: in medullary thyroid cancer. [2012]
Vandetanib, an orally active, small-molecule, multitargeted tyrosine kinase
inhibitor, demonstrates potent inhibitory activity against vascular endothelial
growth factor receptor (VEGFR)-2 and -3, epidermal growth factor receptor (EGFR)
and the rearranged during transfection (RET) tyrosine kinase receptor...
Botulinum toxin a versus placebo for refractory detrusor overactivity in women: a
randomised blinded placebo-controlled trial of 240 women (the RELAX study). [2012]
treatment of DO... CONCLUSIONS: This randomised controlled trial of BoNTA for refractory DO, the
Prospective randomized comparison of onabotulinumtoxinA (Botox) and
abobotulinumtoxinA (Dysport) in the treatment of forehead, glabellar, and
periorbital wrinkles. [2012]
California) and abobotulinumtoxinA (BoNT-ABO; Dysport, Ipsen Ltd, Slough, UK)... CONCLUSIONS: At the current pricing of the agents, BoNT-ABO offers a significant
Clinical Trials Related to Botox (Botulinum Toxin Type A)
Comparison of Korean Botulinum Toxin Type A Versus Botox in the Treatment of Essential Blepharospasm [Completed]
To compare the efficacy and safety of Korean botulinum toxin A (KbtxA, Pacific
Pharmaceuticals, Korea) against Botox in the treatment of essential blepharospasm, we
performed a double-blinded, randomized, comparative trial comparing KbtxA and Botox for
treatment of blepharospasm in 60 patients of the intention to treat population and 52
patients (26 patients from each group) of the per protocol population. The improvement of
severity of spasm (SS) at 4 weeks post-injection as a primary efficacy outcome, qualifying
non inferiority to the control group, Changes in eyelid closure force (CF) and functional
visual status (FVS) after injection for secondary efficacy outcomes, and adverse effects for
safety evaluation. Improvement of SS was noted in 90. 3% of the KbtxA group and 86. 2% of the
Botox group. There were no significant differences between treatment groups in the changes of
CF and FVS after injection (p>0. 05). Adverse effects developed in 16. 1% of the KbtxA group
and 27. 6% of the Botox group, but no serious adverse events were found in either group. KbtxA
was not inferior to Botox in treatment efficacy and was clinically safe with no serious
adverse effects when used to treat essential blepharospasm.
Comparative Study of the Effect of Dysport and Botox [Completed]
The purpose of this study is to test the effect of Dysport and Botox on forehead wrinkles and
EMG activity.
Over Active Bladder Instillation Study - Botox [Recruiting]
The purpose of this study is to determine whether women with overactive bladder (OAB) who
receive direct instillation via a catheter of a Botulinum-A Toxin (Botox) with Dimethyl
Sulfoxide (DMSO) solution experience significantly better improvement of their OAB symptoms
when compared to a similar group of women with OAB who receive instillation of DMSO only.
Study to Determine If the Volume Used to Dilute BOTOX Cosmetic™ for Injection Affects Its Overall Effect and Duration. [Completed]
It is thought that the amount of fluid used to dilute Botox for injection has an effect on
the quality of the result and the duration of effect on the treatment of upper face rhytides,
even though the dose remains the same.
The study was designed to test this thinking, using the crow's feet wrinkles as the treatment
area.
Botulinum Toxin Type A (Dysport) Associated With Rehabilitation Treatment in Patients With Primary Myofascial Pain Syndrome [Completed]
The main purpose of this study is to determine the effectiveness and safety of one dose of
botulinum toxin type A (Dysport) associated with rehabilitation treatment on pain control in
patients with a type of back pain called primary myofascial pain syndrome.
Reports of Suspected Botox (Botulinum Toxin Type A) Side Effects
Headache (14),
Dysphagia (14),
Vision Blurred (12),
Fatigue (10),
Eyelid Ptosis (10),
Dyspnoea (10),
Anxiety (10),
Muscular Weakness (9),
Respiratory Disorder (8),
Pyrexia (8), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 9 ratings/reviews, Botox has an overall score of 6.67. The effectiveness score is 9.11 and the side effect score is 6.89. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Botox review by 51 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | migraines |
| Dosage & duration: | | 1 vial (dosage frequency: every 3-6 months) for the period of five plus years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I used to have near-daily migraines. I tried every migraine medication on the market. Either they didn't have any effect, or I was unable to tolerate them due to side-effects. With Botox injections administered by a very knowledgable neurologist who is also a pain specialist, I am virtually migraine-free for months. |
| Side effects: | | Sometimes I had some minor swelling at an injection site. It went away within days. |
| Comments: | | My neurologist injects the tiny cranial muscles as well as muscles along my neck and upper shoulder. He uses a tiny needle and injects very little at each site. He determines where the trigger points are before administering the Botox. PLEASE NOTE: If using Botox for migraines, do go to a neurologist who is experienced with migraine pain. DO NOT have this done by a cosmetic surgeon! |
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| | Botox review by 42 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | wrinkles |
| Dosage & duration: | | 40 vials (dosage frequency: every 6 months) for the period of every 6 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Wrinkles did disapear, but there was bruising and swelling. It did reduce after a few days, and I noticed the inability to move the muscles in my forehead and around my mouth. |
| Side effects: | | Bruising and swelling. Not sure if it was the way the injections were delivered or because of my tendency to bruise. |
| Comments: | | The vials were injected around my mouth, eyes, and on the forhead. The effect did last for several months, but I had not been happy about the side effects. |
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| | Botox review by 44 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | cosmetic/frown lines |
| Dosage & duration: | | 50 units (dosage frequency: four different visits) for the period of two years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Did have elimination of frown lines and crows feet but no one cares about having wrinkles or not when you are paralyzed. Sadly wrinkles returned in 6 months but large nerves in my legs and and body continue to suffer daily with weakness several years later. Risks too great for some temporary cosmetic procedure |
| Side effects: | | Botulism. Permanent disability. Neuropathy, autonomic nerve injury. chronic myalgias. Chronic nerve pain
Chronic long term muscle weakness. Difficulty breathing, difficulty swallowing, blurry vision. Disabling muscle weakness. permanent paresthesias. |
| Comments: | | Injected by qualified personnel. National Botox trainer. Used 50 units total with a dilution of 1cc per 100 unit vial. injected with several sites at frown lines and crows feet. |
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Page last updated: 2013-05-06
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