Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.
Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril (Phendimetrazine)
Underestimating size can lead to tolerance of obesity
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2014.09.19]
Size is relative, especially to people who tend to be on the heavy side. Researchers at the Columbia University Medical Center in the US found that seven in every ten obese adults underestimate how...
Source: MedicineNet Exercise and Activity Specialty [2014.09.19]
Title: Childhood Obesity
Category: Diseases and Conditions
Created: 5/25/2011 4:58:00 PM
Last Editorial Review: 9/19/2014 12:00:00 AM
Could artificial sweeteners promote diabetes and obesity?
Source: Diabetes News From Medical News Today [2014.09.18]
Artificial sweeteners are often recommended to aid weight loss and help manage type 2 diabetes. But a new study suggests they could actually have the opposite effect.
SFRP5 Correlates With Obesity and Metabolic Syndrome
Source: Medscape Diabetes & Endocrinology Headlines [2014.09.17]
Can this anti-inflammatory adipokine predict metabolic syndrome in children?
Cities with more nature trails have higher levels of youth activity and lower youth obesity
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2014.09.16]
As youth obesity levels in America remain at record high levels, health professionals and policymakers continue to search for solutions to this national health issue.
Published Studies Related to Bontril (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.