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Bontril (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL SUMMARY

BONTRIL®
SLOW RELEASE
BRAND OF
PHENDIMETRAZINE TARTRATE
SLOW-RELEASE CAPSULES
mg

Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.

Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.


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NEWS HIGHLIGHTS

Media Articles Related to Bontril (Phendimetrazine)

Soda tax is 'the best option' for reducing childhood obesity
Source: Nutrition / Diet News From Medical News Today [2014.08.30]
A new study compares the impact three recommended federal policies will have on childhood obesity over 20 years. A 1ยข tax on sugary drinks is the researchers' preferred option.

Tackling obesity via education and dog-friendly neighborhoods
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2014.08.29]
A study from the University of Liverpool has recommended investing in dog owner education and facilities as a strategy to target physical inactivity and problems such as obesity in both people and...

Adolescent weight gain/obesity can be a result of prenatal alcohol exposure
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.08.28]
Fetal Alcohol Spectrum Disorders (FASD) refer to a range of disabilities, and include individuals with neurocognitive impairments as well as growth irregularities ranging from deficient to normal.

Diabetes study finds hidden 'obesity' genes
Source: Diabetes News From Medical News Today [2014.08.28]
People who are obese and have type 2 diabetes are often told that overeating and a sedentary lifestyle are the main causes of their condition.

Research reveals high insulin levels tied to obesity pathway
Source: Diabetes News From Medical News Today [2014.08.28]
UT Southwestern Medical Center researchers have identified a crucial link between high levels of insulin and pathways that lead to obesity, a finding that may have important implications when...

more news >>

Published Studies Related to Bontril (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Page last updated: 2014-08-30

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