Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.
Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril (Phendimetrazine)
EU Finally Gives Green Light to New Obesity Drug
Source: Medscape Diabetes & Endocrinology Headlines [2014.12.19]
After many years with no new obesity drugs in their armamentarium, European physicians may soon have access to bupropion/naltrexone as an option to help aid weight loss.
Morning Break: Obesity as Disability, Fat-Fighting Holiday Decor
Source: MedPage Today Endocrinology [2014.12.18]
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff.
CREB3L3 May Be Target for Obesity, Diabetes Treatments
Source: MedPage Today Endocrinology [2014.12.17]
(MedPage Today) -- Transcription factor boost improved obesity, diabetes in mouse models.
Similarities between obesity and addiction
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.12.15]
A paper published by Obesity Reviews compares neurological responses to reward in participants with obesity, substance addiction and non substance (or behavioural addiction, such as gambling.
Surgeon warns of obesity-related kidney stone 'timebomb'
Source: Diabetes News From Medical News Today [2014.12.15]
A leading surgeon based at Southampton's teaching hospitals has warned the UK is sitting on a kidney stone "timebomb" fuelled by the growing obesity crisis.
Published Studies Related to Bontril (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.
Clinical Trials Related to Bontril (Phendimetrazine)
Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a
pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
be conducted in which the subjective and physiological effects of cocaine are evaluated
during maintenance on placebo and phendimetrazine.
Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural
form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as
the basal levels of TCT in normal human skin and adipose tissue.