BONTRIL SUMMARY
BONTRIL®
SLOW RELEASE
BRAND OF
PHENDIMETRAZINE TARTRATE
SLOW-RELEASE CAPSULES
mg
Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.
Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.
|
NEWS HIGHLIGHTSMedia Articles Related to Bontril (Phendimetrazine)
AHA: Obesity and Smoking Major Risk Factors for VTE (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2009.11.19]
ORLANDO (MedPage Today) -- Overweight smokers have the greatest risk of a venous thrombotic event, according to a review of data from the Copenhagen City Heart Study reported here.
AHA: Obesity Okay with Some People (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2009.11.19]
ORLANDO (MedPage Today) -- Nearly one obese person in 10 feels no need to lose weight or prevent further weight gain, researchers found.
Appalachia, Southeast Hit Hardest by Obesity and Diabetes (HealthDay)
Source: Y! Health Diabetes News [2009.11.19]
HealthDay - THURSDAY, Nov. 19 (HealthDay News) -- While rates of obesity are
climbing across America, they are especially high in sections of
Appalachia and the Southeast, the U.S. Centers for Disease Control and
Prevention reports in its first county-by-county survey.
Increased Obesity Hindering Success At Reducing Heart Disease Risk
Source: Cholesterol News From Medical News Today [2009.11.18]
The dramatic increase in overweight and obesity in adult Americans over the past 20 years has undermined public health success at reducing risk for heart disease, according to research presented at the American Heart Association's Scientific Sessions 2009. In a new study, researchers analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 1988-2006, representing 8,264 adult men and women, 20 to 85 years old.
Obesity Rates Will Continue To Increase, Drive Health Care Costs In Pennsylvania Over Next Decade, According To New Study
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2009.11.18]
A new report released based on research by Emory University Health Care Economist Ken Thorpe, Ph.D., Executive Director of the Partnership to Fight Chronic Disease (PFCD), shows increasing obesity rates in Pennsylvania and across the country will result in higher health care spending for states and individuals.
Published Studies Related to Bontril (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.
|
