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Bontril (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL SUMMARY

BONTRIL®
SLOW RELEASE
BRAND OF
PHENDIMETRAZINE TARTRATE
SLOW-RELEASE CAPSULES
mg

Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.

Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.


See all Bontril indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Bontril (Phendimetrazine)

Alarming increases in pre-diabetes and diabetes in blacks, Hispanics and the elderly; obesity partly to blame
Source: Diabetes News From Medical News Today [2014.04.18]
Cases of diabetes and pre-diabetes in the United States have nearly doubled since 1988, suggests new research from the Johns Hopkins Bloomberg School of Public Health, with obesity apparently to...

Arabian Knives: Curbing an Obesity 'Epidemic'
Source: MedPageToday.com - medical news plus CME for physicians [2014.04.18]
(MedPage Today) -- As an epidemic of obesity and diabetes surges in the Persian Gulf states, a bariatric surgeon from New York City recently packed up his scalpel to lend a steady hand.

Tonsillectomy May Spur Weight Gain in Kids, But Won't Cause Obesity: Study
Source: MedicineNet Obesity (Weight Loss) Specialty [2014.04.18]
Title: Tonsillectomy May Spur Weight Gain in Kids, But Won't Cause Obesity: Study
Category: Health News
Created: 4/17/2014 4:36:00 PM
Last Editorial Review: 4/18/2014 12:00:00 AM

Weight gain in children occurs after tonsil removal, not linked to obesity
Source: Ear, Nose and Throat News From Medical News Today [2014.04.17]
Weight gain in children after they have their tonsils removed (adenotonsillectomy) occurs primarily in children who are smaller and younger at the time of the surgery, and weight gain was not...

Obesity: are lipids hard drugs for the brain?
Source: Neurology / Neuroscience News From Medical News Today [2014.04.17]
Why can we get up for a piece of chocolate, but never because we fancy a carrot?

more news >>

Published Studies Related to Bontril (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Page last updated: 2014-04-18

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