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Bontril (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL SUMMARY

Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.

Phendimetrazine tartrate extended-release capsules are indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

Below is a chart of Body Mass Index (BMI) based on various heights and weights.

BMI is calculated by taking the patient's weight, in kilograms (kg), divided by the patient's height, in meters (m), squared. Metric conversions are as follows: pounds ÷ 2.2 = kg; inches × 0.0254 = meters

BODY MASS INDEX (BMI), kg/m2 Height (feet, inches)

Weight
(pounds)
5?0? 5?3? 5?6? 5?9? 6?0? 6?3?
140 27 25 23 21 19 18
150 29 27 24 22 20 19
160 31 28 26 24 22 20
170 33 30 28 25 23 21
180 35 32 29 27 25 23
190 37 34 31 28 26 24
200 39 36 32 30 27 25
210 41 37 34 31 29 26
220 43 39 36 33 30 28
230 45 41 37 34 31 29
240 47 43 39 36 33 30
250 49 44 40 37 34 31

Phendimetrazine tartrate is indicated for use as monotherapy only.


See all Bontril indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Bontril (Phendimetrazine)

Obesity-Cancer Link in Lynch Syndrome Quashed by Aspirin
Source: Medscape Medical News Headlines [2015.08.21]
Obese individuals with Lynch syndrome have an increased risk for colorectal cancer that appears to be eliminated by regular aspirin.
Medscape Medical News

Medical News Today: Scientists discover 'obesity master switch' for burning or storing fat
Source: Featured Health News from Medical News Today [2015.08.20]
Scientists have discovered a genetic pathway, which - when manipulated - shows pro- and anti-obesity effects by switching between storage and burning in fat cells.

Scientists discover 'obesity master switch' for burning or storing fat
Source: Biology / Biochemistry News From Medical News Today [2015.08.20]
Scientists have discovered a genetic pathway, which - when manipulated - shows pro- and anti-obesity effects by switching between storage and burning in fat cells.

A metabolic master switch underlying human obesity
Source: Cancer / Oncology News From Medical News Today [2015.08.20]
Obesity is one of the biggest public health challenges of the 21st century. Affecting more than 500 million people worldwide, obesity costs at least $200 billion each year in the United States alone...

Scientists Probe Obesity's Ties to Breast Cancer Risk
Source: MedicineNet Obesity (Weight Loss) Specialty [2015.08.20]
Title: Scientists Probe Obesity's Ties to Breast Cancer Risk
Category: Health News
Created: 8/19/2015 12:00:00 AM
Last Editorial Review: 8/20/2015 12:00:00 AM

more news >>

Published Studies Related to Bontril (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

more studies >>

Clinical Trials Related to Bontril (Phendimetrazine)

Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as the basal levels of TCT in normal human skin and adipose tissue.

more trials >>


Page last updated: 2015-08-21

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