Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.
Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril (Phendimetrazine)
Study shows how troubled marriage, depression history promote obesity
Source: Anxiety / Stress News From Medical News Today [2014.10.25]
The double-whammy of marital hostility and a history of depression can increase the risk for obesity in adults by altering how the body processes high-fat foods, according to new research.
Could sun exposure help prevent obesity, diabetes?
Source: Diabetes News From Medical News Today [2014.10.24]
Exposure to ultraviolet radiation slowed weight gain and diabetes in mice fed a high-fat diet, a new study finds. Researchers say this is down to a compound called nitric oxide.
Obesity link to increased risk for orthopedic conditions and surgical complications
Source: Bones / Orthopedics News From Medical News Today [2014.10.22]
Obesity affects individual patient care, the healthcare system and nearly every organ in the body.
Analysis examines genetic obesity susceptibility, association with body size in kids
Source: Genetics News From Medical News Today [2014.10.22]
A review of medical literature appears to confirm an association between genetic obesity susceptibility and postnatal gains in infant weight and length, as well as showing associations with both...
Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds
Source: MedicineNet Exercise and Activity Specialty [2014.10.22]
Title: Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds
Category: Health News
Created: 10/21/2014 12:00:00 AM
Last Editorial Review: 10/22/2014 12:00:00 AM
Published Studies Related to Bontril (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.