Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2- phenylmorpholine Tartrate.
Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see ACTIONS) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril (Phendimetrazine)
Menopause, Obesity, and Diabetes Top ENDO 2015 Agenda
Source: Medscape Diabetes & Endocrinology Headlines [2015.02.27]
The Endocrine Society's annual meeting, which has moved to March, will feature new clinical guidelines for menopause treatment, a look at diabetes drug safety, and precision medicine in endocrinology.
Medscape Medical News
Widely used food additive promotes colitis, obesity and metabolic syndrome, research shows
Source: Diabetes News From Medical News Today [2015.02.27]
Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation that promotes...
Should America go vegan to ward off obesity and save the environment?
Source: Nutrition / Diet News From Medical News Today [2015.02.27]
Separate reports from the Physicians Committee for Responsible Medicine and Dietary Guidelines Advisory Committee make the case for Americans to adopt a plant-based diet.
Too many food choices exacerbate the battle against obesity, researchers find
Source: Nutrition / Diet News From Medical News Today [2015.02.26]
Nurture, not nature, could be a larger issue when dealing with the obesity epidemicSome scientists say that when mothers eat poorly during pregnancy, they pass along traits to their children that...
Progress in Tackling Obesity 'Unacceptably Slow'
Source: Medscape Diabetes & Endocrinology Headlines [2015.02.23]
Changes at both a public-policy and healthcare-provider level are urgently required if significant inroads into the obesity crisis are to be made, warn experts.
Medscape Medical News
Published Studies Related to Bontril (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.
Clinical Trials Related to Bontril (Phendimetrazine)
Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a
pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
be conducted in which the subjective and physiological effects of cocaine are evaluated
during maintenance on placebo and phendimetrazine.
Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural
form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as
the basal levels of TCT in normal human skin and adipose tissue.