BONTRIL PDM SUMMARY
BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.
Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril PDM (Phendimetrazine)
Study increases understanding of the development of obesity and insulin resistance
Source: Diabetes News From Medical News Today [2013.12.06]
The first study of its kind, led by Melinda Sothern, PhD, CEP, Professor and Director of Behavioral and Community Health Sciences at LSU Health Sciences Center New Orleans School of Public Health, reveals that the same pro-inflammatory proteins linked to obesity and the metabolic syndrome in adults appear to protect children prior to puberty.
The obesity-cancer link: even with healthy BMI, greater visceral fat may put older men at risk for cancer
Source: Cancer / Oncology News From Medical News Today [2013.12.05]
Researchers at the National Institute for Aging are working to improve understanding about obesity and cancer.
Risk of serious complications after immediate breast reconstruction with implants increased by obesity, smoking
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2013.12.05]
New risk-scoring tool allows surgeons to better counsel and potentially change an operative plan for women at higher risk for implant failure after mastectomy, Journal of the American College of Surgeons study reports.
'Healthy Obesity' Is a Myth, Report Says
Source: MedicineNet Obesity (Weight Loss) Specialty [2013.12.03]
Title: 'Healthy Obesity' Is a Myth, Report Says
Category: Health News
Created: 12/2/2013 5:36:00 PM
Last Editorial Review: 12/3/2013 12:00:00 AM
Childhood exercise 'may reduce effects of maternal obesity'
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2013.11.29]
A new animal study suggests that children of obese mothers could reduce their risk of developing negative health effects linked to obesity by exercising during childhood. This is according to a study published in the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
Published Studies Related to Bontril PDM (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.