BONTRIL PDM SUMMARY
BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.
Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.
Media Articles Related to Bontril PDM (Phendimetrazine)
Body temperature & obesity: new study suggests connection
Source: Biology / Biochemistry News From Medical News Today [2015.03.20]
A new study suggests that a biological inability to create sufficient core body heat could be linked to the obesity epidemic.
David Cameron obesity benefit proposals "ethically and financially questionable"
Source: Diabetes News From Medical News Today [2015.03.20]
The UK Prime Minister's recent proposal to cut sickness benefit for people who are obese and refuse treatment is ethically and financially flawed, according to an Editorial in The Lancet Diabetes ...
Obesity may not reliably predict atherosclerosis in Mexican-Americans
Source: Cardiovascular / Cardiology News From Medical News Today [2015.03.19]
Blood sugar, insulin resistance and blood pressure may be more reliable indicators of atherosclerosis among Mexican-Americans than obesity, finds a new study.
Slow Medicine: A Role for Obesity Surgery
Source: MedPage Today Cardiovascular [2015.03.19]
(MedPage Today) -- The Slow Medicine approach to bariatric surgery.
Childhood Obesity Linked to Adult Knee Pain (CME/CE)
Source: MedPage Today Primary Care [2015.03.19]
(MedPage Today) -- Males may be especially affected, new study reports.
Published Studies Related to Bontril PDM (Phendimetrazine)
Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.
Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.
Fatality from illicit phendimetrazine use. 
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.
Clinical Trials Related to Bontril PDM (Phendimetrazine)
Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a
pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
be conducted in which the subjective and physiological effects of cocaine are evaluated
during maintenance on placebo and phendimetrazine.
Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural
form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as
the basal levels of TCT in normal human skin and adipose tissue.