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Bontril PDM (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL PDM SUMMARY

BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.

Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.


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NEWS HIGHLIGHTS

Media Articles Related to Bontril PDM (Phendimetrazine)

Obesity Tied to Brain Volume Loss
Source: Medscape NeurologyHeadlines [2014.11.21]
Overweight and obese adults have smaller hippocampal volumes at baseline and greater hippocampal atrophy over 8 years than their normal-weight peers.
Medscape Medical News

Exposure to antibiotics in the womb increases risk of childhood obesity
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today [2014.11.21]
A study just released by Columbia University's Mailman School of Public Health found that children who were exposed to antibiotics in the second or third trimester of pregnancy had a higher risk of...

Seniors’ Obesity-Counseling Benefit Goes Largely Unused
Source: MedPage Today Endocrinology [2014.11.20]
(MedPage Today) -- Less than 1% of Medicare beneficiaries have used the benefit.

Postcode lottery over diabetes and obesity risk highlighted by geographer
Source: Diabetes News From Medical News Today [2014.11.18]
Professor involved in study to describe uses of Geographical Information Systems in free public lecture on Dec.

Chemical in coffee may help prevent obesity-related disease
Source: Diabetes News From Medical News Today [2014.11.18]
Researchers at the University of Georgia have discovered that a chemical compound commonly found in coffee may help prevent some of the damaging effects of obesity.

more news >>

Published Studies Related to Bontril PDM (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Page last updated: 2014-11-21

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