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Bontril PDM (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL PDM SUMMARY

BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.

Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.


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NEWS HIGHLIGHTS

Media Articles Related to Bontril PDM (Phendimetrazine)

Smoking Around Toddlers May Raise Their Obesity Risk
Source: MedicineNet Obesity (Weight Loss) Specialty [2015.06.25]
Title: Smoking Around Toddlers May Raise Their Obesity Risk
Category: Health News
Created: 6/24/2015 12:00:00 AM
Last Editorial Review: 6/25/2015 12:00:00 AM

Obesity: small intestine contributes to chronic inflammation
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2015.06.22]
Obesity is caused by numerous and complex factors, some of which are as yet unsuspected.

Grandparental support helps reduce the risk of child obesity
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2015.06.22]
According to a study published in the journal Pediatric Obesity, emotional support from grandparents has a protective effect against child obesity, even with the presence of other risk factors.

WSU scientists turn white fat into obesity-fighting beige fat
Source: Nutrition / Diet News From Medical News Today [2015.06.19]
A new twist on the health benefits of resveratrolWashington State University scientists have shown that berries, grapes and other fruits convert excess white fat into calorie-burning "beige" fat...

SCOPE program developed to engage communities in preventing childhood obesity
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2015.06.17]
Research highlights the need of community partnerships to create healthier environments for childrenA multidisciplinary group of researchers from British Columbia has developed a participatory...

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Published Studies Related to Bontril PDM (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Clinical Trials Related to Bontril PDM (Phendimetrazine)

Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as the basal levels of TCT in normal human skin and adipose tissue.

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Page last updated: 2015-06-25

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