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Bontril PDM (Phendimetrazine Tartrate) - Summary

 
 



BONTRIL PDM SUMMARY

BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.

Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.


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NEWS HIGHLIGHTS

Media Articles Related to Bontril PDM (Phendimetrazine)

Correlates of overweight and obesity among adolescents with bipolar disorder in the national comorbidity survey
Source: Bipolar News From Medical News Today [2016.12.02]
Bipolar disorder is one of the most disabling medical conditions among adolescents worldwide.

Diabetes and obesity could be prevented with novel protein
Source: Diabetes News From Medical News Today [2016.11.29]
Researchers may have found a way to stop diabetes and improve metabolism in mice, potentially leading to major advancement in treatment of human diabetes.

New target receptor discovered in the fight against obesity
Source: Diabetes News From Medical News Today [2016.11.28]
The team of scientists from King's College London and Imperial College London tested a high-fat diet, containing a fermentable carbohydrate, and a control diet on mice and looked at the effect on...

Jet lag and obesity share similar pathways to liver cancer
Source: Cancer / Oncology News From Medical News Today [2016.11.24]
Since 1980, the incidence of hepatocellular carcinoma, the most common type of liver cancer, has nearly tripled, and obesity related liver disease is one of the driving forces behind the increasing...

Children born by Cesarean section may have a greater risk of obesity
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2016.11.14]
Compared with vaginally-delivered children, those born by Cesarean section had a 1.4 times greater odds of becoming overweight or obese in childhood.

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Published Studies Related to Bontril PDM (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Clinical Trials Related to Bontril PDM (Phendimetrazine)

Reinforcing Effects of Cocaine During Phendimetrazine Maintenance [Recruiting]
This study will determine the initial efficacy of phendimetrazine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Phendimetrazine and Cocaine [Recruiting]
This study will determine the safety and tolerability of phendimetrazine (Bontril«) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Stemcells for Radiation Induced Xerostomia [Enrolling by invitation]
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants. The project can potentially help to develop a clinically relevant treatment option for the growing number of patients suffering from xerostomia after radiotherapy. The development of new therapies is especially important, since only sub-optimal symptomatic treatments are currently available and the symptom of xerostomia greatly reduces the quality of life.

Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars [Recruiting]
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as the basal levels of TCT in normal human skin and adipose tissue.

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Page last updated: 2016-12-02

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