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Bontril PDM (Phendimetrazine Tartrate) - Summary

 



BONTRIL PDM SUMMARY

BONTRIL PDM (phendimetrazine tartrate) is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines.

Bontril® PDM (phendimetrazine tartrate) is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use such as those described below.


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NEWS HIGHLIGHTS

Media Articles Related to Bontril PDM (Phendimetrazine)

Government Called To Action On Obesity And Climate Change, Australia
Source: Health News from Medical News Today [2010.03.15]
Australian politicians must act quickly to combat the rise of obesity and its life-threatening disease consequences, and the great threats to health from global climate change, according to a letter published in the Medical Journal of Australia. The letter has been endorsed by 300 medical and health practitioners, including 40 professors of medicine and health sciences. Prof Garry Egger, Adjunct Professor of Health Sciences at Southern Cross University, NSW, and his co-authors write that big health gains have been made since the onset of industrialisation...


Cutting Obesity In Black, Latino New Yorkers
Source: Nutrition / Diet News From Medical News Today [2010.03.13]
A $6 million grant from the National Heart, Lung and Blood Institute (NHLBI) has funded the creation of ORBIT: Obesity Related Behavioral Intervention Trials to focus on reducing obesity and obesity-related deaths in New York City's African-American and Latino communities...

Tackling Childhood Obesity With Get Up, Get Out And Go!
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2010.03.13]
Getting children involved in finding ways to become more physically active can not only make them more aware of local recreational opportunities, but can even help increase their own physical activity. That's the result of a study examining the role of seven national parks in contributing to the health of today's youth...

Joint Role Of Obesity And Alcohol In Increasing The Risk Of Liver Disease
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2010.03.12]
Obesity and alcohol act together to increase the risk of liver disease in both men and women according to two studies published on bmj.com today. These findings have significant clinical and public health implications. In the UK, rates of liver disease and obesity are increasing. Alcohol is a major cause of liver cirrhosis...

Obesity, Drinking Double Up to Harm Liver (CME/CE)
Source: MedPage Today Gastroenterology [2010.03.12]
A combination of obesity and alcohol consumption puts men and women at higher risk of liver disease, a pair of new studies found.

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Published Studies Related to Bontril PDM (Phendimetrazine)

Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. [2006.03]
Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines... Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. [1998.10]
A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. A normal urinalysis and serum creatinine were documented at the start of therapy... This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine.

A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. [1989.02]
A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard.

Fatality from illicit phendimetrazine use. [1988]
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug... In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.

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Page last updated: 2010-03-15

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