NEWS HIGHLIGHTS
Published Studies Related to Biltricide (Praziquantel)
Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species. [2009.09]
In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus...
Efficacy and safety of emodepside 2.1%/praziquantel 8.6% spot-on formulation in the treatment of feline aelurostrongylosis. [2009.08]
The objective of the present study was to evaluate the efficacy and safety of the antiparasitic spot-on formulation containing emodepside 2.1%/praziquantel 8.6% (Profender, Bayer) in the treatment of natural feline infection with the lungworm Aelurostrongylus abstrusus (Nematoda, Strongylida)...
Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature cestode infections in dogs. [2009.08]
The efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against intestinal cestodes was investigated in four randomised, blinded placebo-controlled dose confirmation studies in dogs experimentally infected with Echinococcus granulosus or E.
Field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (Profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs. [2009.08]
A controlled, blinded and randomised multicentre field study evaluated the efficacy and safety of a new anthelmintic tablet formulation containing emodepside plus praziquantel (Profender tablets for dogs) in the treatment of gastrointestinal nematode and cestode infections in dogs in France, Germany, Portugal and Slovakia...
Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs. [2009.08]
This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs...
Clinical Trials Related to Biltricide (Praziquantel)
Evaluation of Praziquantel Dosage for Treatment of Schistosomiasis in Brazil [Completed]
The primary objective of this project is to evaluate the efficacy and safety of praziquantel
60 mg/kg in the treatment of schistosomiasis, as compared to the standard 40 mg/kg therapy in
a representative community from a highly endemic area of schistosomiasis in Northeastern
Brazil. Cure rates, reduction in egg counts and proportions of reported side-effects in
children at the 10-19 y age-range with at least 100 eggs per gram of faeces will be compared
between regimens, aiming to evaluate the superiority of 60 mg/kg over the 40mg/kg dose
currently recommended by the WHO. Reinfection rates will also be evaluated aiming to improve
transmission control within the local health system, including re-treatment combined with
auxiliary control measures. Features related to the clinical, nutritional and immunological
status of the patients prior to treatment will also be investigated in association with the
outcome of praziquantel treatment.
Comparing Praziquantel Versus Artesunate + Sulfamethoxypyrazine/Pyrimethamine for Treating Schistosomiasis [Completed]
Treatment of Patients With Cysticercosis With Praziquantel or Albendazole [Recruiting]
The purpose of this study is to evaluate, treat and follow patients with cysticercosis, an
infection with the larval form of the pork tapeworm, T. solium. When people ingest cysts of
T. solium eggs, cysts develop in the muscles, brain and other organs. The cysts enlarge and
cause inflammation, usually in the brain. Patients may develop seizures, headache, nausea,
vomiting, inability to walk, poor vision due to enlargement of the brain, and increased
pressure in the brain. Other neurological problems may develop depending on the location of
the cysts. The drugs praziquantel and albendazole are used to treat cysticercosis, but it is
not clear if these drugs are effective in all patients, such as those with calcified cysts
or brain enlargement.
Patients with suspected or confirmed cysticercosis may be eligible for this study.
Participants will be hospitalized for 2 _ to 3 weeks and will take either praziquantel or
albendazole by mouth for 2 weeks. They may receive a corticosteroid to lessen the side
effects of the drug therapy. Patients will be evaluated with medically indicated tests and
procedures that may include:
- Blood tests.
- X-rays of the head and long bones.
- Electroencephalogram - recording of the electrical activity of the brain
- Lumbar puncture (spinal tap) - examination of the cerebrospinal fluid that bathes the
brain and spinal cord. For this procedure, a local anesthetic is given and a needle is
inserted in the space between the bones (vertebrae) in the lower back. About 2
tablespoons of fluid is collected through the needle.
- Eye examination.
- Magnetic resonance imaging (MRI) to examine the brain. MRI uses a strong magnetic field
and radio waves instead of X-rays to demonstrate structural and chemical changes in the
brain. During the scan, the patient lies on a table in a narrow cylinder (the scanner).
He or she can speak with a staff member via an intercom system at all times during the
procedure.
- Computed tomography (CT) to examine the brain. CT can be done from different angles and
allows the doctor to view the brain in small sections in 3-dimensions. The patient lies
on a table with the head positioned in the CT scanner.
Some of the tests may be repeated on the last day of therapy and at 3 and 6 months or longer
after therapy.
The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda [Completed]
The overall objective of the project is to contribute to an increased knowledge about the
effect of praziquantel on schistosomiasis related morbidity and re-infection level among
communities living along Lake Victoria in Mayuge district, Uganda with the overall aim of
improving the strategies for morbidity control.
The study will be carried out in a high transmission area along Lake Victoria, in Mayuge
district. It will be a randomised intervention study, comparing a single praziquantel
treatment (40mg/kg) with two standard doses administered two weeks apart.
Neurocysticercosis: Combined Treatment With Praziquantel and Albendazole [Recruiting]
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