Greater myelotoxicity (e.g., leukopenia and neutropenia) have been reported when carmustine was combined with cimetidine (see ADVERSE REACTIONS: Hematologic Toxicity).
OVERDOSAGE
No proven antidotes have been established for BiCNU overdosage.
CONTRAINDICATIONS
BiCNU should not be given to individuals who have demonstrated a previous hypersensitivity to it.