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Betaseron (Interferon Beta-1B) - Drug Interactions, Contraindications, Overdosage, etc



Drug Interactions

No formal drug interaction studies have been conducted with Betaseron. In the placebo controlled studies in MS, corticosteroids or ACTH were administered for treatment of relapses for periods of up to 28 days in patients (N=664) receiving Betaseron.


Safety of doses higher than 0.25 mg every other day has not been adequately evaluated. The maximum amount of Betaseron that can be safely administered has not been determined.


Betaseron is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta, Albumin (Human), USP, or any other component of the formulation.


No evidence or experience suggests that abuse or dependence occurs with Betaseron therapy; however, the risk of dependence has not been systematically evaluated.


1 Poser CM, et al. Ann Neurol 1983; 13(3): 227-231

2 Kurtzke JF. Neurology 1983; 33(11): 1444-1452

U.S. Patent No. 4,588,585; 4,961,969; 5,702,699; 6,994,847

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