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Betamethasone (Betamethasone Dipropionate Topical) - Summary

 
 



BETAMETHASONE SUMMARY

Betamethasone Dipropionate Cream contains betamethasone dipropionate USP, a synthetic adrenocorticosteroid, for dermatologic use. Betamethasone, an analog of prednisolone, has high corticosteroid activity and slight mineral-ocorticoid activity. Betamethasone dipropionate is the 17,21-dipropionate ester of betamethasone.

Betamethasone Dipropionate Cream is a medium-potency corticosteroid indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 13 years and older.


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NEWS HIGHLIGHTS

Published Studies Related to Betamethasone (Betamethasone Topical)

Chinese medicine combined with calcipotriol betamethasone and calcipotriol ointment for Psoriasis vulgaris (CMCBCOP): study protocol for a randomized controlled trial. [2014]
BACKGROUND: Psoriasis causes worldwide concern because of its high-prevalence, as well as its harmful, and incurable characteristics... DISCUSSION: To address the effectual remission of the YXBCM01 granule for PV, this trial may provide a novel regimen for PV patients if the granule can decrease relapse rate without more adverse effects.

Calcipotriene plus betamethasone dipropionate topical suspension for the treatment of mild to moderate psoriasis vulgaris on the body: a randomized, double-blind, vehicle-controlled trial. [2013]
and limbs... CONCLUSION: The topical suspension containing calcipotriene plus betamethasone

Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. [2012]
0.1% cream... CONCLUSION: A. vera/olive oil cream was at least as effective as betamethasone

Efficacy and safety of the Betamethasone valerate 0.1% plaster in mild-to-moderate chronic plaque psoriasis: a randomized, parallel-group, active-controlled, phase III study. [2011.06.01]
BACKGROUND: Corticosteroids are a versatile option for the treatment of mild-to-moderate psoriasis due to their availability in a wide range of potencies and formulations. Occlusion of the corticosteroid is a widely accepted procedure to enhance the penetration of the medication, thereby improving its effectiveness. Betamethasone valerate (BMV) is a moderately potent corticosteroid that is available as a cream, ointment, and lotion. A ready-to-use occlusive dressing, which provides a continuous sustained release of BMV, has been developed for the treatment of psoriasis. OBJECTIVE: To evaluate the efficacy and safety of a new BMV 0.1% plaster compared with a BMV 0.1% cream in patients with mild-to-moderate chronic plaque psoriasis... CONCLUSIONS: BMV 0.1% plaster is more efficacious than BMV 0.1% cream in the treatment of patients with mild-to-moderate chronic plaque psoriasis in a clinical setting resembling daily clinical practice.

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. [2011.05]
PURPOSE: To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.

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Clinical Trials Related to Betamethasone (Betamethasone Topical)

Evaluation of Efficacy and Safety of Epidural Steroid Injection Using Dexamethasone or Betamethasone [Completed]
Particle steroid drug such as triamcinolone has been used widely for epidural steroid injection (ESI) treatment in Korea. However, Korea FDA recently prohibit ESI using triamcinolone, following the regulation of US FDA. Therefore, dexamethasone and betamethasone become only candidate drugs for ESI in Korea and the investigators are curious about the effectiveness and safety of both drugs due to limitation of information about comparison of two drugs in previous literature. So, this study aims to compare the effectiveness and safety of both drugs and our hypothesis is that there is no difference of the effectiveness between dexamethasone and betamethasone at 2 weeks after ESI.

Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of [Completed]
ABSTRACT: The aim of this study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence. This study has not been carried out in Iran. 99 patients of either sex undergoing elective surgery were recruited in a single blind randomized study. The patients, using randomization table, were divided into three groups. Anesthetics and medications used during surgery were similar for all the patients. For the all patients, the incidence of postoperative sore throat, cough and hoarseness of the voice in the different follow-up periods (1, 6 and 24 hours) based on the different types of medications were obtained.

Antepartum Betamethasone Treatment for Prevention of Respiratory Distress in Infants Born by Elective Cesarean Section [Terminated]
This is a randomized, multicenter, double blind, placebo controlled trial of betamethasone versus a placebo given prior to the mothers at term and near term gestation (>34 and <40 weeks of gestation) who are scheduled to undergo a planned Cesarean section. The study design is to determine the efficacy and safety of betamethasone in the prevention of breathing problems commonly seen in this population. In infants born by elective Cesarean section, it is hypothesized that antenatal betamethasone treatment will reduce the risk of neonatal intensive care unit (NICU) admission from 11% to 8% and/or oxygen therapy +/- positive pressure ventilation (PPV) for >30 minutes from 4. 5% to 2. 5%.

Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428) [Completed]
This study attempts to document the therapeutic value of combining loratadine antihistamine action (no sedative) with anti-inflammatory effects of betamethasone at low doses, which may facilitate treatment adherence by patients whereas providing an effective and rapid perennial allergic rhinitis (PAR) symptoms relief.

Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure [Completed]
Glaucoma is one of the leading causes of blindness worldwide and trabeculectomy is the most commonly performed operation to slow-down the disease progression. In this study, we compare the effect of topical cyclosporine A and betamethasone eye drops on the postoperative course and surgical success of trabeculectomy.

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Reports of Suspected Betamethasone (Betamethasone Topical) Side Effects

Maternal Exposure During Pregnancy (25)Foetal Exposure During Pregnancy (24)Premature Baby (22)LOW Birth Weight Baby (15)Premature Delivery (12)Drug Ineffective (11)Eczema (9)Condition Aggravated (8)Death Neonatal (8)Insomnia (8)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Betamethasone has an overall score of 6. The effectiveness score is 6.67 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
 

Betamethasone review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   itchy, red, irritated skin
Dosage & duration:   0.1% topical cream (dosage frequency: twice daily) for the period of 1 week
Other conditions:   Candida albicans (vaginal yeast infection)
Other drugs taken:   fluconazole 150 mg (CanesOral)
  
Reported Results
Benefits:   Immediate relief and full recovery within 1 week.
Side effects:   None
Comments:   I had been suffering from repeated yeast infections that I hadn't been able to cure on my own with traditional store-bought treatments. After over 2 months of chronic scratching, the skin of my outer vulva was red, sore and still outrageously itchy. My gynaecologist prescribed Betaderm to be applied twice daily for 2 weeks, and it worked amazingly well with no side effects.

 

Betamethasone review by 71 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Trochanteric Bursitis
Dosage & duration:   5 mg/amp + 2 mg/amp taken injection for the period of two injectios
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   After the administration of the first injection the pain decreased, however after a period of two weeks it returned. A second injection was administered. There was no improvement and undesirable side effects, as described below, appeared.
Side effects:   Two days after the 2nd injection the body weight started to increase. In the forth day it was 1.5 kg heigher. In the following four days it returned to almost normal. During this period I felt tired and dizzy and fainted at one occasion. The blood test indicated that the concentrations of potassium and sodium were outside the normal limits (Potassium too high, 5.3 mmol/L and sodium too low, 134 mmol/L), in a dangerous range. Similarly to the pH, the safe range for these two ions is narrow. Four days later the potassium was OK, 5.1 mmol/L albeit high, but the sodium, remained unchanged. In additional three days, the sodium was OK,136 mmol/L ,albeit low. I continued to feel tired for the next two weeks
Comments:   Two injections were administered in a period of two weeks

 

Betamethasone review by 71 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Trochanteric Bursitis
Dosage & duration:   5 mg/amp + 2 mg/amp taken injection for the period of two injectios
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   After the administration of the first injection the pain decreased, however after a period of two weeks it returned. A second injection was administered. There was no improvement and undesirable side effects, as described below, appeared.
Side effects:   Two days after the 2nd injection the body weight started to increase. In the forth day it was 1.5 kg heigher. In the following four days it returned to almost normal. During this period I felt tired and dizzy and fainted at one occasion. The blood test indicated that the concentrations of potassium and sodium were outside the normal limits (Potassium too high, 5.3 mmol/L and sodium too low, 134 mmol/L), in a dangerous range. Similarly to the pH, the safe range for these two ions is narrow. Four days later the potassium was OK, 5.1 mmol/L albeit high, but the sodium, remained unchanged. In additional three days, the sodium was OK,136 mmol/L ,albeit low. I continued to feel tired for the next two weeks
Comments:   Two injections were administered in a period of two weeks

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Page last updated: 2014-11-30

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