Betamethasone (Betamethasone Dipropionate Topical) - Summary

BETAMETHASONE SUMMARY

Betamethasone Dipropionate Cream, USP 0.05% (Augmented)*

Betamethasone dipropionate cream (augmented) contains betamethasone dipropionate, USP, a synthetic adrenocorticosteroid, for dermatologic use in an emollient base. Betamethasone, an analog of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticoid activity. Betamethasone dipropionate is the 17,21-dipropionate ester of betamethasone.

Betamethasone dipropionate cream (augmented) is a high-potency corticosteroid indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 13 years and older.

See all Betamethasone indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Betamethasone (Betamethasone Topical)

Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. [2012]
0.1% cream... CONCLUSION: A. vera/olive oil cream was at least as effective as betamethasone

Efficacy and safety of the Betamethasone valerate 0.1% plaster in mild-to-moderate chronic plaque psoriasis: a randomized, parallel-group, active-controlled, phase III study. [2011.06.01]
BACKGROUND: Corticosteroids are a versatile option for the treatment of mild-to-moderate psoriasis due to their availability in a wide range of potencies and formulations. Occlusion of the corticosteroid is a widely accepted procedure to enhance the penetration of the medication, thereby improving its effectiveness. Betamethasone valerate (BMV) is a moderately potent corticosteroid that is available as a cream, ointment, and lotion. A ready-to-use occlusive dressing, which provides a continuous sustained release of BMV, has been developed for the treatment of psoriasis. OBJECTIVE: To evaluate the efficacy and safety of a new BMV 0.1% plaster compared with a BMV 0.1% cream in patients with mild-to-moderate chronic plaque psoriasis... CONCLUSIONS: BMV 0.1% plaster is more efficacious than BMV 0.1% cream in the treatment of patients with mild-to-moderate chronic plaque psoriasis in a clinical setting resembling daily clinical practice.

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. [2011.05]
PURPOSE: To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.

Doxepin cream vs betamethasone cream for treatment of chronic skin lesions due to sulfur mustard. [2011.05]
Oral doxepin was shown to reduce chronic pruritus due to sulfur mustard. The present study compared the effects of topical doxepin 5% with betamethasone 1% for the treatment of pruritus in veterans exposed to sulfur mustard...

Significant one week efficacy of a calcipotriol plus betamethasone dipropionate scalp formulation. [2011.01]
BACKGROUND: A two-compound scalp formulation containing calcipotriol (50 mug/g) and betamethasone (0.5mg/g; as dipropionate) (Xamiol, Taclonex Scalp) has been shown to be an effective and safe treatment for scalp psoriasis. OBJECTIVE: The aim of this study was to investigate the clinical efficacy of the two-compound scalp formulation after 1 week of treatment...

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Clinical Trials Related to Betamethasone (Betamethasone Topical)

Efficacy and Safety of Calcipotriene/Betamethasone Gel/Ointment in Psoriasis [Completed]
Patients will receive either a gel containing both calcipotriene plus betamethasone or gel with no active ingredients as treatment for their scalp psoriasis for 8 weeks. After this time all patients will receive the gel containing both calcipotriene and betamethasone for 44 weeks. In addition, patients will receive an ointment containing both calcipotriene plus betamethasone as treatment for their psoriasis of the trunk and limbs for 52 weeks.

The objective is to study the short-term efficacy of the gel, and the short and long-term safety of the gel and the ointment.

Safety and Efficacy of Quadriderme® in the Treatment of Impetiginous Eczema (Study P05134AM4) [Recruiting]
This is a parallel-group, randomized, active-controlled, double-blind, Phase 4 trial comparing three creams in the treatment of impetiginous eczema:

- Arm A: QUADRIDERME® cream (betamethasone diproprionate, clotrimazole and gentamicin

sulfate)

- Arm B: Combination of betamethasone diproprionate cream and gentamicin sulfate cream

- Arm C: Betamethasone diproprionate cream

At 7 sites, in Portugal, a total of 207 subjects will be randomized using a 1: 1:1 randomization ratio to receive one of the three possible treatments for a maximum period of 28 days or until 5 days after total remission of the signs and symptoms, but never more than 28 days. Assessments will be made of level of improvement of the target area in each treatment group, number of days for total remission, and safety profile.

Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus [Completed]
Discoid lupus erythematosus lesions are commonly treated with corticosteroids, but corticosteroids may induce side effects such as thinning of the skin or scarring. Therefore, an alternative medication with the same efficacy, but without the side-effects is sought after.

Pimecrolimus is a newer drug specially designed to treat inflammatory diseases of skin. Its efficacy in treating discoid lupus erythematosus has not been studied extensively yet. However studies performed till now show promising results. Long-term topical use of this medication has not shown any serious side-effects in other skin diseases.

In this study we aimed at comparing pimecrolimus efficacy with that of a common therapeutic choice, betamethasone valerate 0. 1% cream, to see if pimecrolimus can be used as an alternative medication in treating discoid lupus erythematosus.

Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis [Not yet recruiting]
Topical corticosteroids are largely used in dermatology. The major problem related to their use is that the same mechanisms underlying their therapeutic effects (antiinflammatory and antiproliferative) may lead to adverse events. Conditions sensitive to corticosteroids require formulations with mild to moderate potency while high-potency corticosteroids era required in less responsive conditions. The aim of the present study is to compare the safety and efficacy of prednisolone acetate 0. 5% cream (mild-potency non-fluoridated corticosteroid) versus betamethasone valerate 0. 1% cream (high-potency fluoridated corticosteroid) in the treatment of mild to moderate cortisosensitive dermatosis (atopic dermatitis, contact dermatitis, seborrheic dermatitis and psoriasis). The study hypothesis is that 0. 5% prednisolone cream will be as effective as 0. 1% betamethasone cream and will be an alternative option to treat corticosensitive dermatosis in body areas where the use of fluoridated corticosteroids is contraindicated, such as the face.

Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Scalp Psoriasis [Completed]
The purpose of the study is to evaluate whether once daily topical treatment for up to 8 weeks of calcipotriol 50 mcg/g plus betamethasone 0. 5 mg/g (as dipropionate) gel is safe and more effective than betamethasone 0. 5 mg/g (as dipropionate) in the gel vehicle and calcipotriol 50 mcg/g in the gel vehicle in patients with scalp psoriasis.

The primary response criterion is the number of patients with absence of disease and very mild disease after 8 weeks of treatment.

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Reports of Suspected Betamethasone (Betamethasone Topical) Side Effects

Maternal Exposure During Pregnancy (25),  Foetal Exposure During Pregnancy (24),  Premature Baby (22),  LOW Birth Weight Baby (15),  Premature Delivery (12),  Drug Ineffective (11),  Eczema (9),  Condition Aggravated (8),  Death Neonatal (8),  Insomnia (8), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Betamethasone review by 40 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		itchy, red, irritated skin
Dosage & duration:		0.1% topical cream (dosage frequency: twice daily) for the period of 1 week
Other conditions:		Candida albicans (vaginal yeast infection)
Other drugs taken:		fluconazole 150 mg (CanesOral)
		Reported Results
Benefits:		Immediate relief and full recovery within 1 week.
Side effects:		None
Comments:		I had been suffering from repeated yeast infections that I hadn't been able to cure on my own with traditional store-bought treatments. After over 2 months of chronic scratching, the skin of my outer vulva was red, sore and still outrageously itchy. My gynaecologist prescribed Betaderm to be applied twice daily for 2 weeks, and it worked amazingly well with no side effects.

Betamethasone review by 71 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Trochanteric Bursitis
Dosage & duration:		5 mg/amp + 2 mg/amp taken injection for the period of two injectios
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		After the administration of the first injection the pain decreased, however after a period of two weeks it returned. A second injection was administered. There was no improvement and undesirable side effects, as described below, appeared.
Side effects:		Two days after the 2nd injection the body weight started to increase. In the forth day it was 1.5 kg heigher. In the following four days it returned to almost normal. During this period I felt tired and dizzy and fainted at one occasion. The blood test indicated that the concentrations of potassium and sodium were outside the normal limits (Potassium too high, 5.3 mmol/L and sodium too low, 134 mmol/L), in a dangerous range. Similarly to the pH, the safe range for these two ions is narrow. Four days later the potassium was OK, 5.1 mmol/L albeit high, but the sodium, remained unchanged. In additional three days, the sodium was OK,136 mmol/L ,albeit low. I continued to feel tired for the next two weeks
Comments:		Two injections were administered in a period of two weeks

Betamethasone review by 71 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Trochanteric Bursitis
Dosage & duration:		5 mg/amp + 2 mg/amp taken injection for the period of two injectios
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		After the administration of the first injection the pain decreased, however after a period of two weeks it returned. A second injection was administered. There was no improvement and undesirable side effects, as described below, appeared.
Side effects:		Two days after the 2nd injection the body weight started to increase. In the forth day it was 1.5 kg heigher. In the following four days it returned to almost normal. During this period I felt tired and dizzy and fainted at one occasion. The blood test indicated that the concentrations of potassium and sodium were outside the normal limits (Potassium too high, 5.3 mmol/L and sodium too low, 134 mmol/L), in a dangerous range. Similarly to the pH, the safe range for these two ions is narrow. Four days later the potassium was OK, 5.1 mmol/L albeit high, but the sodium, remained unchanged. In additional three days, the sodium was OK,136 mmol/L ,albeit low. I continued to feel tired for the next two weeks
Comments:		Two injections were administered in a period of two weeks