BETADINE SUMMARY
Betadine® 5% Sterile Ophthalmic Prep Solution (povidone-iodine ophthalmic solution) (0.5% available iodine)
Povidone-Iodine is a broad-spectrum microbicide compound with iodine.
BETADINE 5% Sterile Ophthalmic Prep Solution for the eye is indicated for prepping of the periocular region (lids, brow, and cheek) and irrigation of the ocular surface (cornea, conjunctiva, and palpebral fornices).
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NEWS HIGHLIGHTS
Published Studies Related to Betadine (Povidone-Iodine Ophthalmic)
A phase II randomized controlled trial to evaluate the safety and efficacy of Praneem polyherbal vaginal tablets compared with betadine vaginal pessary in women with symptoms of abnormal vaginal discharge. [2009.10]
Abnormal vaginal discharge (AVD) caused by a variety of reproductive tract infections is a widespread syndrome among women in India and in other developing countries. The purpose of this study was to determine whether a polyherbal formulation, Praneem, can be used for the regression of the syndrome...
Periurethral cleaning prior to urinary catheterization in children: sterile water versus 10% povidone-iodine. [2009.07]
OBJECTIVE: To compare urinary infection rate in children cleaned with sterile water versus a 10% povidone-iodine before bladder catheterization... CONCLUSIONS: Cleaning the periurethral area of children with sterile water prior to catheterization is not inferior to cleaning with povidone-iodine.
Comparison of the effect of water vs. povidone-iodine solution for periurethral cleaning in women requiring an indwelling catheter prior to gynecologic surgery. [2009.03]
This study compared rates of bacteriuria and urinary tract infections in 60 women randomized to periurethral area cleansing with water or povidone-iodine solution prior to insertion of an indwelling urinary catheter. A urine specimen was collected immediately before and 24 hours after catheter insertion.
Randomized controlled clinical trial on the evaluation of bacteriostatic and cariostatic effects of a novel povidone-iodine/fluoride foam in children with high caries risk. [2009.03]
CONCLUSION: As far as bacteriostatic and cariostatic effects are concerned, clinical application of povidone-iodine/fluoride foam shows no superiority over the regular fluoride foam during a 1-year period. Evidence is still lacking for the combination use of povidone-iodine and fluoride to achieve a better caries-prevention effect in a high-caries-risk population.
A randomized trial of 2% chlorhexidine tincture compared with 10% aqueous povidone-iodine for venipuncture site disinfection: Effects on blood culture contamination rates. [2008.05]
BACKGROUND: Contaminated blood cultures have been recognized as a bothersome issue, and continue to cause frustration for clinicians. Skin antiseptics can prevent blood culture contamination. To our knowledge, there have been no randomized studies to compare 2% alcoholic chlorhexidine and 10% aqueous povidone-iodine for venipuncture site disinfection. OBJECTIVE: This study aimed to evaluate the efficacy of venipuncture site disinfection with 2% chlorhexidine in 70% alcohol and 10% aqueous povidone-iodine in preventing blood culture contamination... CONCLUSION: Two percent alcoholic chlorhexidine is superior to 10% aqueous povidone-iodine for venipuncture site disinfection before obtaining blood cultures.
Clinical Trials Related to Betadine (Povidone-Iodine Ophthalmic)
Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) [Not yet recruiting]
Continuous femoral nerve block (CFNB) techniques continue to be increasingly used in the
management of postoperative pain after total knee arthroplasty. Although the risk of full
blown infection with CFNB has been poorly defined, the rate of catheter colonization after
antisepsis with povidone-iodine has been demonstrated to be high (Cuivillion et al. showed
the rate of colonization to be 57% after 48 hours). Recently, several anecdotal case reports
have demonstrated severe infectious complications including psoas abscess and necrotizing
fasciitis associated with continuous nerve block techniques. As the use of CFNB techniques
increase in popularity, infectious complications will undoubtedly become more common.
The American Society of Regional Anesthesia and Pain Medicine recommends the routine use of
antiseptic solutions with an alcohol base for skin disinfection before peripheral regional
techniques due to their penetration of the stratum corneum and their rapid and prolonged
effect. Chlorhexidine(chloraprep) has been proven to be better than povidone iodine solution
for skin preparation before epidural catheter and intravascular device insertion (Kinirons
et al., Ostrander et al., Mimoz et al.,). The goal of this prospective trial therefore is to
determine if an alcoholic solution of 0. 5% chlorhexidine is more effective than an aqueous
solution of 10% povidone-iodine in reducing catheter colonization and reducing skin flora
associated with short term ( 48 hours) postoperative continuous femoral nerve catheter
placement. The investigators will also compare the ability of chloraprep and betadine
disinfection at the time of catheter placement to prevent bacterial contamination of the
continuous femoral catheter.
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections [Recruiting]
The purpose of this study is to find out if chlorhexidine gluconate solution is better at
reducing the rate of wound infection after cesarean section compared to povidone-iodine.
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine [Not yet recruiting]
The purpose of this study is to determine the effectiveness of 1. 25% povidone-iodine
ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers
compared with an antifungal antibiotic.
Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery [Recruiting]
The purpose of this study is to determine if there is a difference on the penetration of
betadine 5% when using lidocaine 2% jelly versus topical tetracaine 0. 5% in topical cataract
surgery. This will be assessed comparing bacterial colony count and species by taking swabs
from the eye surface before and after the topical anesthesia has been administered.
A Randomised Study to Assess Betadine in the Groin Wound of Patients Undergoing Primary Varicose Vein Surgery [Recruiting]
To investigate whether Betadine can reduce infection rates and recurrence rates following
varicose veins surgery in a randomized double blind placebo controlled study.
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