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Betadine (Povidone-Iodine Ophthalmic) - Summary



Betadine® 5%
Sterile Ophthalmic
Prep Solution
(povidone-iodine ophthalmic solution)
(0.5% available iodine)

Povidone-Iodine is a broad-spectrum microbicide compound with iodine.

BETADINE 5% Sterile Ophthalmic Prep Solution for the eye is indicated for prepping of the periocular region (lids, brow, and cheek) and irrigation of the ocular surface (cornea, conjunctiva, and palpebral fornices).

See all Betadine indications & dosage >>


Published Studies Related to Betadine (Povidone-Iodine Ophthalmic)

Treatment of Epidemic Keratoconjunctivitis with 2% Povidone-Iodine: A Pilot Study. [2011.09.14]
Abstract Purpose: The purpose of this study was to analyze the outcome of treating epidemic keratoconjunctivitis (EKC) with 2% povidone-iodine (PVP-I) solution. Methods: A prospective, interventional, uncontrolled study was performed in participants diagnosed with EKC...

Preparation of corneal donor eyes comparing 1% versus 5% povidone-iodine. [2011.03]
PURPOSE: To compare the effect of 1% versus 5% polyvinylpyrrolidone-iodine (PVP-I) chemical preparation (prep) of the eye on the recovery of organisms from donor globes before in situ recovery of donor corneal tissue... CONCLUSIONS: This study found that 1% and 5% PVP-I solutions are equally effective for chemical prep of the donor eye. Because PVP-I is known to be toxic to the corneal endothelium and corneal fibroblasts, this study suggests that 1% PVP-I should be the preferred disinfectant for the recovery of corneal donors.

Povidone-iodine: an anti-oedematous agent? [2011.02]
Polyvinylpyrrolidone-iodine (PVP-I) is a well-known antiseptic, widely used in various preparations and concentrations in all surgical fields. It is also used as an irrigant for open wounds and in some centres for irrigating sockets after tooth extraction...

Use of povidone-iodine drop instead of sub-conjunctival injection of dexamethasone and gentamicin combination at the end of phacoemulsification cataract surgery. [2010.04]
To evaluate the use of 5% povidone-iodine drop with subconjunctival injection of dexamethasone and gentamicin combination at the completion of phacoemulsification cataract surgery. This prospective randomized study was conducted at the department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July, 2005 to June 2006...

Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis. [2010.01.07]
BACKGROUND: Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine... CONCLUSIONS: Preoperative cleansing of the patient's skin with chlorhexidine-alcohol is superior to cleansing with povidone-iodine for preventing surgical-site infection after clean-contaminated surgery. (ClinicalTrials.gov number, NCT00290290.) 2010 Massachusetts Medical Society

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Clinical Trials Related to Betadine (Povidone-Iodine Ophthalmic)

Dilute Betadine Lavage in the Prevention of Postoperative Infection [Recruiting]
The purpose of this study is to examine the efficacy of a dilute betadine solution in reducing infectious complications in revision total knee arthroplasty. The investigators will enroll patients who are scheduled to undergo a revision total knee arthroplasty. Patients will be randomized into two groups. The treatment group will receive a dilute betadine lavage prior to surgical closure for 3 minutes followed by 2000ml of sterile saline irrigation and the control group will receive the 2000ml sterile saline lavage alone.

Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) [Recruiting]
Continuous femoral nerve block (CFNB) techniques continue to be increasingly used in the management of postoperative pain after total knee arthroplasty. Although the risk of full blown infection with CFNB has been poorly defined, the rate of catheter colonization after antisepsis with povidone-iodine has been demonstrated to be high (Cuivillion et al. showed the rate of colonization to be 57% after 48 hours). Recently, several anecdotal case reports have demonstrated severe infectious complications including psoas abscess and necrotizing fasciitis associated with continuous nerve block techniques. As the use of CFNB techniques increase in popularity, infectious complications will undoubtedly become more common. The American Society of Regional Anesthesia and Pain Medicine recommends the routine use of antiseptic solutions with an alcohol base for skin disinfection before peripheral regional techniques due to their penetration of the stratum corneum and their rapid and prolonged effect. Chlorhexidine(chloraprep) has been proven to be better than povidone iodine solution for skin preparation before epidural catheter and intravascular device insertion (Kinirons et al., Ostrander et al., Mimoz et al.,). The goal of this prospective trial therefore is to determine if an alcoholic solution of 0. 5% chlorhexidine is more effective than an aqueous solution of 10% povidone-iodine in reducing catheter colonization and reducing skin flora associated with short term ( 48 hours) postoperative continuous femoral nerve catheter placement. The investigators will also compare the ability of chloraprep and betadine disinfection at the time of catheter placement to prevent bacterial contamination of the continuous femoral catheter.

Efficacy of 2% Chlorhexidine Gluconate in 70% Alcohol Compare 10% Povidone Iodine in Blood Culture in Children [Completed]
To evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.

Povidone Iodine and Cesarean Section Wound Infections [Completed]
The aim of this randomized clinical trial is to compare the efficiency of hand scrubbing by Povidone-Iodine solution 10% over 7. 5% concentration in decreasing post-cesarean section wound infections & compare side effects of both agents.

ChloraPrep Versus Betadine for Elective Knee Replacement Surgery [Terminated]
This study will enroll patients who will be receiving primary total knee replacements. Subjects will be randomized into two groups: Betadine surgical scrub preparation and ChloraPrep preparation prior to total knee replacements. Study hypothesis: When used as a surgical scrub preparation prior to primary total knee arthroplasties, ChloraPrep (2% chlorhexadine gluconate and 70% isopropyl alcohol) is superior to Betadine (10% povidone iodine) in reducing incision site bacterial colony counts.

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Reports of Suspected Betadine (Povidone-Iodine Ophthalmic) Side Effects

Toxic Anterior Segment Syndrome (37)Medication Error (20)Endophthalmitis (8)Post Procedural Complication (7)Drug Hypersensitivity (7)Rash Maculo-Papular (4)Anaphylactic Shock (3)Visual Acuity Reduced (3)Rash Erythematous (3)Pruritus (2)more >>

Page last updated: 2011-12-09

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