BENZACLIN SUMMARY
BenzaClin® Topical Gel
(clindamycin - benzoyl peroxide gel)
BenzaClin® Topical Gel contains clindamycin phosphate, (7(S)-chloro-7-deoxylincomycin-2-phosphate). Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.
BenzaClin Topical Gel is indicated for the topical treatment of acne vulgaris.
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NEWS HIGHLIGHTSMedia Articles Related to Benzaclin (Clindamycin Topical)
EMA: Benefits Outweigh VTE Risks With Hormone Drugs for Acne
Source: Medscape Medical News Headlines [2013.05.17]
The EMA has issued a recommendation that the benefits of the hormonal acne treatment Diane and its generics outweigh the risks, provided that several measures are taken to minimize the risk of thromboembolism.
International Approvals
Research Letter Suggests Twitter May Serve As A Good Forum For Communicating Information About Acne
Source: Health News from Medical News Today [2013.05.17]
JAMA Dermatology Study Highlights A research letter by Kamal Jethwani, M.D., M.P.H., of the Center for Connected Health, Boston, and colleagues suggests that clinicians can learn about the perceptions and misconceptions of diseases like acne via Twitter, and communicate reliable medical information on the popular social media platform...
Pediatricians Endorse New Acne Treatment Guidelines
Source: MedicineNet Acne Specialty [2013.05.06]
Title: Pediatricians Endorse New Acne Treatment Guidelines
Category: Health News
Created: 5/6/2013 10:35:00 AM
Last Editorial Review: 5/6/2013 12:00:00 AM
Tx for Pediatric Acne Gets New Guidance (CME/CE)
Source: MedPage Today Dermatology [2013.05.04]
(MedPage Today) -- Typically seen as a teenager's disease, acne also presents in children and infants, and treatments should be age appropriate, according to new recommendations from the American Acne and Rosacea Society.
With Acne, Bacteria Strain on Your Skin May Be Culprit
Source: MedicineNet Acne Specialty [2013.02.28]
Title: With Acne, Bacteria Strain on Your Skin May Be Culprit
Category: Health News
Created: 2/28/2013 10:35:00 AM
Last Editorial Review: 2/28/2013 12:00:00 AM
Published Studies Related to Benzaclin (Clindamycin Topical)
Fitzpatrick skin types and clindamycin phosphate 1.2%/benzoyl peroxide gel:
efficacy and tolerability of treatment in moderate to severe acne. [2012]
efficacy of acne medications in skin of color... CONCLUSIONS: Acne subjects with Fitzpatrick skin types IV-VI were not found to be
Treatment of moderate to severe acne vulgaris in a Hispanic population: a
post-hoc analysis of efficacy and tolerability of clindamycin phosphate
1.2%/benzoyl peroxide 2.5% gel. [2012]
in Hispanics... CONCLUSIONS: Overall efficacy and tolerability with clindamycin phosphate
A randomized, double-blind, placebo-controlled, pilot study to assess the
efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for
the treatment of acne rosacea over 12 weeks. [2012]
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%
Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. [2011.11]
BACKGROUND: Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acne... CONCLUSIONS: Topical nadifloxacin, a new fluoroquinolone is effective, tolerable, and safe for mild o moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide.
Efficacy of topical combination of benzoyl peroxide 5% and clindamycin 1% for the treatment of progressive macular hypomelanosis: a randomized, doubleblind, placebo-controlled trial. [2011.02]
BACKGROUND: Progressive macular hypomelanosis is a dermatosis without definite etiology. There is no consensus or first-line therapy in the treatment of progressive macular hypomelanosis, and the treatment options used are very little effective. OBJECTIVE: To evaluate the therapeutic efficacy of the topical combination of benzoyl peroxide 5% and clindamycin 1% associated with sun exposure for the treatment of progressive macular hypomelanosis... CONCLUSION: The topical combination of benzoyl peroxide 5% and clindamycin 1% is effective in the treatment of progressive macular hypomelanosis.
Clinical Trials Related to Benzaclin (Clindamycin Topical)
A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac� Topical Gel in the Treatment of Acne Vulgaris [Recruiting]
The objective of this study is to compare the relative efficacy and safety of the test
formulation Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Taro Pharmaceuticals Inc.) to
the marketed formulation Duac® Topical Gel (Clindamycin 1%/Benzoyl Peroxide 5%) (Stiefel) in
the treatment of the inflamed lesions of acne vulgaris. Both the test and reference
formulations will also be compared to a placebo formulation to test for superiority.
Study Comparing Clindamycin Phosphate and Benzoyl Peroxide Gel to Acanya� Gel and Both to a Vehicle Control in the Treatment of Acne Vulgaris [Recruiting]
The objective of this study is to compare the safety and efficacy profiles of Taro
Pharmaceutical Inc.'s Clindamycin Phosphate and Benzoyl Peroxide Gel 1. 2%/2. 5% to Acanya®
(Clindamycin Phosphate and Benzoyl Peroxide) Gel, 1. 2%/2. 5% and to demonstrate the superior
efficacy of the two active formulations over that of the vehicle in the treatment of acne
vulgaris.
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris [Recruiting]
The purpose of this study is to compare the effectiveness of two marketed products in
subjects with facial acne vulgaris
Comparing OTC Acne Treatment to Prescription Regimen [Recruiting]
This research is being done to find out the safety and efficacy of two acne creams, Effaclar
and Benzaclin when used twice daily with a topical retinoid. Effaclar and Benzaclin are FDA
approved for the treatment of acne.
Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris [Recruiting]
This study is to determine the efficacy and safety of 12 week treatment with Differin® Gel
0. 3% applied in the evening, in combination with Duac® (Clindamycin/Benzoyl Peroxide Gel)
applied in the morning, in Subjects with Acne vulgaris.
Reports of Suspected Benzaclin (Clindamycin Topical) Side Effects
Colitis Ulcerative (4),
Gastrointestinal Haemorrhage (2),
Drug Ineffective (2),
Loss of Consciousness (2),
Oesophageal Ulcer (2),
Anaemia (2),
Odynophagia (2),
Small Intestinal Obstruction (2),
Diarrhoea (2),
Leukocytosis (2), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Benzaclin has an overall score of 8. The effectiveness score is 8.67 and the side effect score is 7.33. The scores are on ten point scale: 10 - best, 1 - worst.
| | Benzaclin review by 28 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | dont remember (dosage frequency: twice a day) for the period of 1 year |
| Other conditions: | | acne scarring |
| Other drugs taken: | | nothing | | |
Reported Results |
| Benefits: | | None |
| Side effects: | | None |
| Comments: | | None |
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| | Benzaclin review by 40 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | topical application (dosage frequency: once daily) for the period of several years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | This has helped reduce my cystic acne that forms on my chin area. Nothing has helped previously.I had tried OTC products including Proactiv as well as RX differin. The cysts still occur occasionally but with far less frequency. |
| Side effects: | | dryness |
| Comments: | | Applied daily in the evening. At first sign of a cyst forming I usually apply it twice daily. |
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| | Benzaclin review by 40 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | topical application (dosage frequency: once daily) for the period of several years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | This has helped reduce my cystic acne that forms on my chin area. Nothing has helped previously.I had tried OTC products including Proactiv as well as RX differin. The cysts still occur occasionally but with far less frequency. |
| Side effects: | | dryness |
| Comments: | | Applied daily in the evening. At first sign of a cyst forming I usually apply it twice daily. |
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Page last updated: 2013-05-17
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