BENTYL SUMMARY
BENTYL®
(dicyclomine hydrochloride USP)
BENTYL is an antispasmodic and anticholinergic (antimuscarinic) agent.
BENTYL is indicated for the treatment of functional bowel/irritable bowel syndrome.
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NEWS HIGHLIGHTSMedia Articles Related to Bentyl (Dicyclomine)
Lexicon Announces Positive Phase 2 Results Of LX1031 In Non-Constipating Irritable Bowel Syndrome
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.13]
Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced that the company's investigational new drug, LX1031, a tryptophan hydroxylase (TPH) inhibitor, demonstrated positive results in clinically important parameters for the treatment of non-constipating irritable bowel syndrome (IBS).
Pharmos Announces Results Of Phase 2b Irritable Bowel Syndrome Study
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.09.15]
Pharmos Corporation (Pink Sheets: PARS) announced the results of its Phase 2b Dextofisopam clinical trial to evaluate safety and efficacy of the compound in irritable bowel syndrome. Although the primary efficacy variable (% of weeks responding for adequate overall relief of IBS symptoms) did not reach statistical significance, the percentage responding for the Dextofisopam 200 mg group was higher than that observed for the Phase 2a trial.
Contrary To Insoluble Fiber, Soluble Fiber Is An Effective Treatment For Irritable Bowel Syndrome
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.08.28]
The first trial in increasing dietary fiber in a primary care setting is published on bmj.com today. It reports that soluble fiber (psyllium) is an effective treatment for irritable bowel syndrome (IBS). On the other hand, insoluble fiber such as bran may worsen symptoms. Irritable bowel syndrome is characterized by abdominal pain and an irregular bowel habit. It affects about 10 percent of the population.
Alternative Treatment For Irritable Bowel Syndrome When Conventional Therapy Has Failed
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.08.13]
IBS remains a common intestinal disorder causing significant discomfort and poor quality of life in patients who have the diagnosis. TCAs have been shown to improve abdominal pain in patients with IBS; however, there is insufficient evidence of global symptom relief. The search for an optimal treatment to improve symptoms and quality of life in IBS remains ongoing. A research article published in the World Journal of Gastroenterology addresses this problem.
Is Somatic Hypersensitivity A Predictor Of Irritable Bowel Syndrome?
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.07.23]
Although visceral hypersensitivity is considered a hallmark feature of IBS, conflicting evidence exists regarding somatic hypersensitivity in this patient population. Several investigators have found no evidence for heightened somatic pain sensitivity in IBS patients. Also, others have reported similar cold presser pain tolerance in IBS patients and controls. These conflicting findings may result from differing somatic pain testing procedures.
Published Studies Related to Bentyl (Dicyclomine)
Dose effect of dicyclomine on the reduction of peristaltic artifacts on MRI of the abdomen. [1999.07]
BACKGROUND: It has been demonstrated that oral administration of dicyclomine significantly reduces the noise associated with the movement of the gastrointestinal tract in abdominal magnetic resonance (MR) images. Our objective was to determine the efficacy and security of two different doses of oral dicyclomine for the reduction of the gastrointestinal noise in abdominal MR imaging... CONCLUSION: Oral dicyclomine is effective and safe for the reduction of peristaltic artifacts on abdominal MR imaging. The dose of 20 mg presents an efficacy similar to that of 80 mg, with a probably lower incidence of adverse reactions.
Dietary modifications versus dicyclomine hydrochloride in the treatment of severe infantile colics. [1994.02]
This study examined 120 infants, aged 3-12 weeks, with severe colics and compared the results of a specific hypoallergenic diet (group A) with those of pharmacological treatment (group B). Non-breast-fed group A infants received soy milk and if unresponsive, hydrolyzed milk formulas; mothers of breast-fed infants received a diet without cow's milk, eggs or fish...
Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury. [2008.11]
Recent studies indicate that alphaII-spectrin breakdown products (SBDPs) have utility as biological markers of traumatic brain injury (TBI). However, the utility of SBDP biomarkers for detecting effects of therapeutic interventions has not been explored...
Dicyclomine for medical management of persistent anal fissure with associated spasm of the internal sphincter. [1992.11]
The case of a 43-year-old woman with persistent anal fissure responsive to dicyclomine is described... Surgery was avoided.
Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. [1977.07.01]
PIP: The effects of doxylamine succinate (DAS) and dicylomin hydrochloride (DHC), each of which is contained in the drug Bendectin, administration during pregnancy on offspring was investigated in a prospective cohort study of 50,282 women and their offspring.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Bentyl has an overall score of 7. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| | Bentyl review by care giver of 54 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | Diaheria assc. w/ chemo |
| Dosage & duration: | | 5mg taken 2/day for the period of 4 days |
| Other conditions: | | mouth sores |
| Other drugs taken: | | flucanazole, immodium, ativan | | |
Reported Results |
| Benefits: | | controlled loose stool and fluid loss due to chemo; nausea control; control of mouth thrush, sores. The Bentil in particular worked much better than immodium for diarhea control and fluid retention. It also stopped colon muscle spasm. |
| Side effects: | | dizziness, fatigue, loss of appetite |
| Comments: | | benil taken 2x a day to control diarhea; flucanzole 1x a day for thrush; rest of medications for nausea |
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Page last updated: 2009-11-13
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