|
USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, BENICAR HCT® should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
|
| |
BENICAR SUMMARY
BENICAR® (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.
BENICAR® is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
|
|
NEWS HIGHLIGHTSMedia Articles Related to Benicar (Olmesartan)
ESH/ESC Publish Hypertension Guidelines
Source: Medscape Medical News Headlines [2013.06.15]
The new guidelines make <140 mm Hg the treatment target for all individuals, with a few minor exceptions, and say that all the drug classes have a role in reducing blood pressure. In addition, the ESH/ESC guidelines emphasize a role for ABPM and reiterate their emphasis on combination therapy.
Heartwire
Vitamin D Can Help Prevent Hypertension
Source: Health News from Medical News Today [2013.06.15]
The world's largest study to examine the link between vitamin D levels and hypertension has found that low levels of Vitamin D can be a major cause of hypertension. Researchers presented their findings at the annual conference of the European Society of Human Genetics (ESHG). Data were gathered from 35 studies, which included more than 155,000 participants from different parts of Europe and North America. Dr. Vimal Karani S, from the Institute of Child Health, University College London, London, UK, led the study...
Hypertension Risk Drops with Volunteer Work (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.06.14]
(MedPage Today) -- Older adults had a significantly lower risk of developing hypertension if they performed at least 200 hours of volunteer service in the previous year, a longitudinal survey showed.
Link Clarified Between Hypertension And Vitamin D Deficiency
Source: Hypertension News From Medical News Today [2013.06.12]
Low levels of vitamin D can trigger hypertension, according to the world's largest study to examine the causal association between the two. Although observational studies have already shown this link, a large-scale genetic study was necessary before the cause and effect could be proven, the annual conference of the European Society of Human Genetics (ESHG) heard. Dr...
Portal Hypertension
Source: MedicineNet Cirrhosis Specialty [2013.06.10]
Title: Portal Hypertension
Category: Diseases and Conditions
Created: 1/31/2005 8:20:00 AM
Last Editorial Review: 6/10/2013 12:00:00 AM
Published Studies Related to Benicar (Olmesartan)
A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil +/- hydrochlorothiazide. [2011.06]
In the prospective, open-label, titrate-to-goal Blood Pressure Control in All Subgroups With Hypertension (BP-CRUSH) study, 999 patients with hypertension uncontrolled on monotherapy (mean age, 55.6 +/- 11.4 years; baseline blood pressure [BP], 153.7 +/- 9.2/91.9 +/- 8.6 mm Hg) were switched to fixed-dose amlodipine/olmesartan medoxomil (AML/OM) 5/20 mg...
Efficacy and safety of olmesartan medoxomil plus amlodipine in age, gender and hypertension severity defined subgroups of hypertensive patients. [2011.06]
Effective antihypertensive therapy is crucial for preventing cardiovascular events; however, blood pressure (BP) control rates remain poor. The objective of this analysis was to determine the efficacy of olmesartan/amlodipine in age, severity and gender-based subgroups of patients with moderate-to-severe hypertension uncontrolled by amlodipine monotherapy...
Antihypertensive efficacy and safety of olmesartan and ramipril in elderly patients with mild to moderate systolic and diastolic essential hypertension. [2011.04]
OBJECTIVE: To compare the efficacy and safety of olmesartan medoxomil (O) and ramipril (R) in elderly patients with essential arterial hypertension... CONCLUSIONS: In elderly patients with essential arterial hypertension, O provides an effective, prolonged and well tolerated blood pressure control, with significantly better blood pressure normalization than R and represents a useful option among first-line drug treatments of hypertension in this age group.
Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. [2011.03]
Azilsartan medoxomil is an angiotensin receptor blocker (ARB) being developed for hypertension treatment. To compare this ARB with others in the class, we studied the effects of 2 doses of azilsartan medoxomil, with valsartan 320 mg and olmesartan medoxomil (olmesartan) 40 mg, in a randomized, double-blind, placebo-controlled trial using ambulatory blood pressure (BP) monitoring and clinic BP measurements...
The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. [2011.02]
The current study assesses the antihypertensive efficacy and safety of the investigational angiotensin receptor blocker (ARB), azilsartan medoxomil (AZL-M), compared with placebo and the ARB olmesartan medoxomil (OLM-M). This randomized, double-blind, placebo-controlled, multicenter study assessed change from baseline in mean 24-hour ambulatory systolic blood pressure (SBP) following 6 weeks of treatment...
Clinical Trials Related to Benicar (Olmesartan)
Olmesartan in Essential Hypertension [Completed]
To test the efficacy and safety of olmesartan in patients with essential hypertension.
An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension [Completed]
Effect of increasing doses of olmesartan medoxomil and olmesartan
medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension
Fed Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fed conditions.
Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fasting conditions.
Parallel-Group Comparison of Olmesartan, Amlodipine and Hydrochlorothiazide in Hypertension [Recruiting]
This study is to determine the change in blood pressure from the administration of
Olmesartan/Amlodipine/Hydrochlorothiazide triple combinations compared to dual combinations
with Olmesartan/Amlodipine.
Reports of Suspected Benicar (Olmesartan) Side Effects
Drug Ineffective (79),
Weight Decreased (43),
Blood Pressure Increased (38),
Hypotension (36),
Headache (29),
Dizziness (28),
Hypertension (23),
Oedema Peripheral (22),
Insomnia (21),
Loss of Consciousness (20), more >>
|
PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Benicar has an overall score of 9. The effectiveness score is 8 and the side effect score is 9.33. The scores are on ten point scale: 10 - best, 1 - worst.
| | Benicar review by 48 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Hypertension |
| Dosage & duration: | | 20mg taken once per day for the period of Ongoing |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | My BP is in a normal range when I take this medication. I only require a very low dose. |
| Side effects: | | I had no side effects. This seems to be a highly effective medication that works at a low dose. |
| Comments: | | I took the pill once per day with or with out food. No other treatment was prescribed. |
|
| | Benicar review by 48 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | hypertension/high blood pressure |
| Dosage & duration: | | 20mg then 40mg taken once daily for the period of three years and still taking it |
| Other conditions: | | anxiety disorder-obesity-sleep apnea |
| Other drugs taken: | | ativan, lasix | | |
Reported Results |
| Benefits: | | lowers blood pressure and helps prevent strokes. Helps the patient to function without the tingling, headaches, and chest pain that comes from having blood pressure too high. |
| Side effects: | | The only side effects I felt was a drained feeling when my blood pressure went down. |
| Comments: | | I take one 40 mg Benicar in the evening because that is when my blood pressure comes up. If I wake up in the middle of the night and my blood pressure is up again from my sleep apnea, then I take another half. I have to drink a lot more water too, as this helps the Benicar to break down quicker. |
|
| | Benicar review by 48 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | hypertension/high blood pressure |
| Dosage & duration: | | 20mg then 40mg taken once daily for the period of three years and still taking it |
| Other conditions: | | anxiety disorder-obesity-sleep apnea |
| Other drugs taken: | | ativan, lasix | | |
Reported Results |
| Benefits: | | lowers blood pressure and helps prevent strokes. Helps the patient to function without the tingling, headaches, and chest pain that comes from having blood pressure too high. |
| Side effects: | | The only side effects I felt was a drained feeling when my blood pressure went down. |
| Comments: | | I take one 40 mg Benicar in the evening because that is when my blood pressure comes up. If I wake up in the middle of the night and my blood pressure is up again from my sleep apnea, then I take another half. I have to drink a lot more water too, as this helps the Benicar to break down quicker. |
|
|
|
Page last updated: 2013-06-15
|
