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Benicar (Olmesartan Medoxomil) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, BENICAR HCT® should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

BENICAR SUMMARY

BENICAR® (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.

BENICAR® is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
See all Benicar indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Benicar (Olmesartan)

UF researchers use plants to study new ways of delivering drugs for pulmonary hypertension
Source: Endocrinology News From Medical News Today [2014.10.17]
UF researchers are using the leaves of plants to study new ways to deliver drugs that treat pulmonary hypertension, a disease with few treatment options, according to a study published online in...

Living closer to major roadways increases hypertension risk
Source: Hypertension News From Medical News Today [2014.10.03]
A new study in the Journal of the American Heart Association reports a significant association between living near a major roadway and the risk of high blood pressure.

Hypertension may be initiated by an autoimmune response
Source: Hypertension News From Medical News Today [2014.09.19]
High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease.

Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Source: Hypertension News From Medical News Today [2014.09.18]
The World Alzheimer Report 2014 'Dementia and Risk Reduction: An analysis of protective and modifiable factors', calls for dementia to be integrated into both global and national public health...

Men who improve their fitness levels can hold off development of hypertension
Source: Hypertension News From Medical News Today [2014.09.17]
A man's cardiorespiratory fitness can drastically delay the natural, age-associated increase of his blood pressure over his adult life span.

more news >>

Published Studies Related to Benicar (Olmesartan)

A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil +/- hydrochlorothiazide. [2011.06]
In the prospective, open-label, titrate-to-goal Blood Pressure Control in All Subgroups With Hypertension (BP-CRUSH) study, 999 patients with hypertension uncontrolled on monotherapy (mean age, 55.6 +/- 11.4 years; baseline blood pressure [BP], 153.7 +/- 9.2/91.9 +/- 8.6 mm Hg) were switched to fixed-dose amlodipine/olmesartan medoxomil (AML/OM) 5/20 mg...

Efficacy and safety of olmesartan medoxomil plus amlodipine in age, gender and hypertension severity defined subgroups of hypertensive patients. [2011.06]
Effective antihypertensive therapy is crucial for preventing cardiovascular events; however, blood pressure (BP) control rates remain poor. The objective of this analysis was to determine the efficacy of olmesartan/amlodipine in age, severity and gender-based subgroups of patients with moderate-to-severe hypertension uncontrolled by amlodipine monotherapy...

Antihypertensive efficacy and safety of olmesartan and ramipril in elderly patients with mild to moderate systolic and diastolic essential hypertension. [2011.04]
OBJECTIVE: To compare the efficacy and safety of olmesartan medoxomil (O) and ramipril (R) in elderly patients with essential arterial hypertension... CONCLUSIONS: In elderly patients with essential arterial hypertension, O provides an effective, prolonged and well tolerated blood pressure control, with significantly better blood pressure normalization than R and represents a useful option among first-line drug treatments of hypertension in this age group.

Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. [2011.03]
Azilsartan medoxomil is an angiotensin receptor blocker (ARB) being developed for hypertension treatment. To compare this ARB with others in the class, we studied the effects of 2 doses of azilsartan medoxomil, with valsartan 320 mg and olmesartan medoxomil (olmesartan) 40 mg, in a randomized, double-blind, placebo-controlled trial using ambulatory blood pressure (BP) monitoring and clinic BP measurements...

The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. [2011.02]
The current study assesses the antihypertensive efficacy and safety of the investigational angiotensin receptor blocker (ARB), azilsartan medoxomil (AZL-M), compared with placebo and the ARB olmesartan medoxomil (OLM-M). This randomized, double-blind, placebo-controlled, multicenter study assessed change from baseline in mean 24-hour ambulatory systolic blood pressure (SBP) following 6 weeks of treatment...

more studies >>

Clinical Trials Related to Benicar (Olmesartan)

Olmesartan in Essential Hypertension [Completed]
To test the efficacy and safety of olmesartan in patients with essential hypertension.

An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension [Completed]
Effect of increasing doses of olmesartan medoxomil and olmesartan medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension

Fed Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1 x 40 mg) dose administered under fed conditions.

Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1 x 40 mg) dose administered under fasting conditions.

Parallel-Group Comparison of Olmesartan, Amlodipine and Hydrochlorothiazide in Hypertension [Recruiting]
This study is to determine the change in blood pressure from the administration of Olmesartan/Amlodipine/Hydrochlorothiazide triple combinations compared to dual combinations with Olmesartan/Amlodipine.

more trials >>

Reports of Suspected Benicar (Olmesartan) Side Effects

Drug Ineffective (79)Weight Decreased (43)Blood Pressure Increased (38)Hypotension (36)Headache (29)Dizziness (28)Hypertension (23)Oedema Peripheral (22)Insomnia (21)Loss of Consciousness (20)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Benicar has an overall score of 9. The effectiveness score is 8 and the side effect score is 9.33. The scores are on ten point scale: 10 - best, 1 - worst.
 

Benicar review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Hypertension
Dosage & duration:   20mg taken once per day for the period of Ongoing
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   My BP is in a normal range when I take this medication. I only require a very low dose.
Side effects:   I had no side effects. This seems to be a highly effective medication that works at a low dose.
Comments:   I took the pill once per day with or with out food. No other treatment was prescribed.

 

Benicar review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   hypertension/high blood pressure
Dosage & duration:   20mg then 40mg taken once daily for the period of three years and still taking it
Other conditions:   anxiety disorder-obesity-sleep apnea
Other drugs taken:   ativan, lasix
  
Reported Results
Benefits:   lowers blood pressure and helps prevent strokes. Helps the patient to function without the tingling, headaches, and chest pain that comes from having blood pressure too high.
Side effects:   The only side effects I felt was a drained feeling when my blood pressure went down.
Comments:   I take one 40 mg Benicar in the evening because that is when my blood pressure comes up. If I wake up in the middle of the night and my blood pressure is up again from my sleep apnea, then I take another half. I have to drink a lot more water too, as this helps the Benicar to break down quicker.

 

Benicar review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   hypertension/high blood pressure
Dosage & duration:   20mg then 40mg taken once daily for the period of three years and still taking it
Other conditions:   anxiety disorder-obesity-sleep apnea
Other drugs taken:   ativan, lasix
  
Reported Results
Benefits:   lowers blood pressure and helps prevent strokes. Helps the patient to function without the tingling, headaches, and chest pain that comes from having blood pressure too high.
Side effects:   The only side effects I felt was a drained feeling when my blood pressure went down.
Comments:   I take one 40 mg Benicar in the evening because that is when my blood pressure comes up. If I wake up in the middle of the night and my blood pressure is up again from my sleep apnea, then I take another half. I have to drink a lot more water too, as this helps the Benicar to break down quicker.

See all Benicar reviews / ratings >>

Page last updated: 2014-10-17

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