NEWS HIGHLIGHTSMedia Articles Related to Benicar (Olmesartan)
A Recipe For Hypertension: High Fructose Corn Syrup
Source: Hypertension News From Medical News Today [2009.10.31]
A diet high in fructose increases the risk of developing high blood pressure (hypertension), according to a paper presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, California. The findings suggest that cutting back on processed foods and beverages that contain high fructose corn syrup (HFCS) may help prevent hypertension.
Hypertension Guidelines Reappraised In Light Of New Research
Source: Hypertension News From Medical News Today [2009.10.30]
A Task Force of the European Society of Hypertension have released the official European guidelines on the management and treatment of hypertension. The guidelines are an update of those published in 2007, and will be published in the November issue of the Journal of Hypertension.
Research Indicates Gaps In Care For Diabetes, Cholesterol, Hypertension Among The Uninsured
Source: Cholesterol News From Medical News Today [2009.10.21]
A new study shows uninsured American adults with chronic illnesses like diabetes or high cholesterol often go undiagnosed and undertreated, leading to an increased risk of costly, disabling and even lethal complications of their disease. The study, published online in Health Affairs, analyzed data from a recent national survey conducted by the Centers for Disease Control and Prevention (CDC).
ESC Press Statement: Accelerated Bone Growth May Be An Indicator Of Hypertension In Children
Source: Hypertension News From Medical News Today [2009.10.21]
Children whose bones are "older" than their chronological age may be at an increased risk of hypertension, according to a study reported (19 October) in Hypertension: Journal of the American Heart Association.(1) As a result, the investigators suggest that markers of biological maturity should be evaluated in hypertensive children, and that physical activity and diet may deter the accelerated development of biological maturity.
Clues to Hypertension in Kids May Be Seen in Bones (HealthDay)
Source: Y! Health Bones, Joints & Muscles News [2009.10.20]
HealthDay - TUESDAY, Oct. 20 (HealthDay News) --
New research links high blood pressure in children to bones that are more
mature than average, suggesting that advanced bone age may predict
cardiovascular problems.
Published Studies Related to Benicar (Olmesartan)
Comparison of olmesartan medoxomil versus amlodipine besylate on regression of ventricular and vascular hypertrophy. [2009.08.01]
Reversal of left ventricular (LV) hypertrophy is an important goal of antihypertensive therapy. This phase 3b study compared the ability of the angiotensin receptor blocker olmesartan medoxomil with the calcium channel blocker amlodipine besylate to induce regression of LV hypertrophy and vascular hypertrophy after achieving blood pressure (BP) goal...
Rationale, design and patient baseline characteristics of OlmeSartan and calcium antagonists randomized (OSCAR) study: a study comparing the incidence of cardiovascular events between high-dose angiotensin II receptor blocker (ARB) monotherapy and combination therapy of ARB with calcium channel blocker in Japanese elderly high-risk hypertensive patients (ClinicalTrials. gov no. NCT00134160). [2009.07]
Higher doses of angiotensin II receptor blockers (ARBs) are expected to exert more protective effects against cardiovascular diseases. However, the significance of treatment of hypertension with high-dose ARB remains to be defined... The OSCAR study is the first large clinical trial comparing the efficacy of high-dose ARB monotherapy with that of an ARB plus CCB combination therapy in elderly high-risk hypertensive patients.
Efficacy and safety of the single pill combination of amlodipine 10 mg plus valsartan 160 mg in hypertensive patients not controlled by amlodipine 10 mg plus olmesartan 20 mg in free combination. [2009.02]
ABSTRACT Background and objective: For patients with moderate hypertension (grade 2, defined as systolic blood pressure [SBP] 160-179 mmHg and/or diastolic blood pressure [DBP] 100-109 mmHg), current guidelines recommend initial combination therapy and rapid dose-adjustment to achieve blood pressure goal...
Pharmacokinetics of olmesartan medoxomil in hemodialysis patients: little effect of dialysis upon its pharmacokinetics. [2009.02]
Olmesartan medoxomil is a new angiotensin-2 receptor blocker (ARB)...
Antihypertensive efficacy of olmesartan medoxomil or valsartan in combination with amlodipine: a review of factorial-design studies. [2009.01]
BACKGROUND: Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents with complementary mechanisms of action, such as calcium channel blockers (CCBs) and angiotensin II-receptor blockers (ARBs). Two fixed-dose CCB/ARB combinations are approved in the US: amlodipine/valsartan (AML/VAL) and amlodipine/olmesartan medoxomil (AML/OM). OBJECTIVES: To review and describe the efficacy of AML/VAL and AML/OM combinations by discussing similarly designed clinical trials... CONCLUSIONS: This review of published factorial-design studies showed that the maximal marketed doses of an amlodipine/olmesartan medoxomil combination (10/40 mg) and an amlodipine/valsartan combination (10/320 mg) produced large reductions in BP from baseline. Limitations of this review include the small number of studies analyzed and the inherent heterogeneity between patient populations. Further research is warranted to directly compare the efficacy of these combinations in a randomized, controlled trial, or additional published clinical trials are required to provide larger data sets for robust meta-analyses and to overcome heterogeneity observed within these studies.
Clinical Trials Related to Benicar (Olmesartan)
Olmesartan in Essential Hypertension [Completed]
To test the efficacy and safety of olmesartan in patients with essential hypertension.
An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension [Completed]
Effect of increasing doses of olmesartan medoxomil and olmesartan
medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension
Fed Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fed conditions.
Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fasting conditions.
Olmesartan and an Add-on Treatment in Patients With Mild to Moderate Hypertension [Completed]
This study is to assess the safety and efficacy of an add-on treatment algorithm with
olmesartan, hydrochlorothiazide and amlodipine in patients with mild to moderate
hypertension.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Benicar has an overall score of 9. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Benicar review by 58 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | high blood pressure |
| Dosage & duration: | | 40 mg taken once a day for the period of still taking it |
| Other conditions: | | none |
| Other drugs taken: | | furosemide, atenolol | | |
Reported Results |
| Benefits: | | The treatment benefits are to help lower blood pressure. Blood pressure is being monitored by the physician and the patient. So far, the benicar has shown to be as beneficial as the previous medicine patient has been on for the last seven years. Since the pill is considerably larger than previous medicine I was on, I do have to chew the pill. |
| Side effects: | | I have not noticed any side effects so far. I have been taking the medicine about one month. I plan to visit the doctor in eight weeks again at which time I am sure the doctor will check my blood for any changes that may have occurred. But so far, nothing has been noticed. |
| Comments: | | I have been on blood pressure medication for about seven years now. Each doctor that I went to has changed my medication several times. My blood pressure has been lower since visiting a nephrologist. Recently I went to a regular general practitioner and she changed my medicine once again to the Benicar. It seems to be helping somewhat with very few, if any, sign effects. |
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