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USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, BENICAR HCT® should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
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BENICAR HCT SUMMARY
BENICAR HCT™ (olmesartan medoxomil-hydrochlorothiazide) is a combination of an angiotensin II receptor antagonist (AT1 subtype), olmesartan medoxomil, and a thiazide diuretic, hydrochlorothiazide (HCTZ).
BENICAR HCT™ is indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).
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NEWS HIGHLIGHTSMedia Articles Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)
A Recipe For Hypertension: High Fructose Corn Syrup
Source: Hypertension News From Medical News Today [2009.10.31]
A diet high in fructose increases the risk of developing high blood pressure (hypertension), according to a paper presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, California. The findings suggest that cutting back on processed foods and beverages that contain high fructose corn syrup (HFCS) may help prevent hypertension.
Hypertension Guidelines Reappraised In Light Of New Research
Source: Hypertension News From Medical News Today [2009.10.30]
A Task Force of the European Society of Hypertension have released the official European guidelines on the management and treatment of hypertension. The guidelines are an update of those published in 2007, and will be published in the November issue of the Journal of Hypertension.
Research Indicates Gaps In Care For Diabetes, Cholesterol, Hypertension Among The Uninsured
Source: Cholesterol News From Medical News Today [2009.10.21]
A new study shows uninsured American adults with chronic illnesses like diabetes or high cholesterol often go undiagnosed and undertreated, leading to an increased risk of costly, disabling and even lethal complications of their disease. The study, published online in Health Affairs, analyzed data from a recent national survey conducted by the Centers for Disease Control and Prevention (CDC).
ESC Press Statement: Accelerated Bone Growth May Be An Indicator Of Hypertension In Children
Source: Hypertension News From Medical News Today [2009.10.21]
Children whose bones are "older" than their chronological age may be at an increased risk of hypertension, according to a study reported (19 October) in Hypertension: Journal of the American Heart Association.(1) As a result, the investigators suggest that markers of biological maturity should be evaluated in hypertensive children, and that physical activity and diet may deter the accelerated development of biological maturity.
Clues to Hypertension in Kids May Be Seen in Bones (HealthDay)
Source: Y! Health Bones, Joints & Muscles News [2009.10.20]
HealthDay - TUESDAY, Oct. 20 (HealthDay News) --
New research links high blood pressure in children to bones that are more
mature than average, suggesting that advanced bone age may predict
cardiovascular problems.
Published Studies Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)
Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients. [2008]
OBJECTIVE: To compare the effect of delapril/manidipine vs olmesartan/hydrochlorothiazide (HCTZ) combination on insulin sensitivity and plasma fibrinogen in obese hypertensive patients... CONCLUSION: In obese hypertensive patients the delapril/manidipine combination but not the olmesartan/HCTZ combination significantly decreased insulin resistance and plasma fibrinogen levels, despite the similar BP lowering efficacy.
Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide. [2004.03]
BACKGROUND: Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ)... CONCLUSIONS: Olmesartan medoxomil/HCTZ combination therapy produced BP reductions of up to 26.8/21.9 mm Hg and was well tolerated.
A review of olmesartan medoxomil monotherapy: antihypertensive efficacy similar to that of other angiotensin II receptor blocker/hydrochlorothiazide combinations? [2002.11]
Angiotensin II receptor blockers (ARBs) have been available in the United States since 1995...
Effects of Manidipine/Delapril versus Olmesartan/Hydrochlorothiazide Combination Therapy in Elderly Hypertensive Patients with Type 2 Diabetes Mellitus. [2008.01]
The purpose of this study was to compare the combination treatments of manidipine/delapril and olmesartan/hydrochlorothiazide (HCTZ) in elderly diabetic hypertensives. After a 4-week placebo period, 158 hypertensive patients with type 2 diabetes (age range: 66 to 74 years) were randomized to receive combination treatment of 10 mg manidipine plus 30 mg delapril or 20 mg olmesartan plus 12.5 mg HCTZ for 48 weeks in a prospective, parallel arm trial...
Olmesartan medoxomil: a review of its use in the management of hypertension. [2008]
Olmesartan medoxomil (Olmetec, Benicar) is an angiotensin II type 1 (AT(1)) receptor antagonist (angiotensin receptor blocker [ARB]) that inhibits the actions of angiotensin II on the renin-angiotensin-aldosterone system, which plays a key role in the pathogenesis of hypertension... In the meantime, the consistent antihypertensive efficacy during the entire 24-hour dosage interval and good tolerability profile of olmesartan medoxomil, with or without HCTZ, make it a valuable option for the treatment of adult patients with hypertension, including the elderly.
Clinical Trials Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)
Olmesartan in Essential Hypertension [Completed]
To test the efficacy and safety of olmesartan in patients with essential hypertension.
An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension [Completed]
Effect of increasing doses of olmesartan medoxomil and olmesartan
medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension
Fed Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fed conditions.
Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan
medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1
x 40 mg) dose administered under fasting conditions.
Olmesartan and an Add-on Treatment in Patients With Mild to Moderate Hypertension [Completed]
This study is to assess the safety and efficacy of an add-on treatment algorithm with
olmesartan, hydrochlorothiazide and amlodipine in patients with mild to moderate
hypertension.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Benicar HCT has an overall score of 9. The effectiveness score is 8 and the side effect score is 8.67. The scores are on ten point scale: 10 - best, 1 - worst.
| | Benicar HCT review by 50 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | hypertension |
| Dosage & duration: | | 25mg taken 1x/day for the period of 2 years |
| Other conditions: | | stress |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | lowered blood presssure with no notable side effects.The reduction in blood pressure was immediate with no other bothersome side effects |
| Side effects: | | none -- i was warned that many blood pressure medications have bothersome side-effects including lowered libido, sleep disturbances etc. i suffered no change in any physiological symptoms other than the lowering of my blood pressure |
| Comments: | | Take the medication once per day and take measures to reduce the sources of stress in my life as well as take measures to more efficiently deal with existant daily stress. |
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| | Benicar HCT review by 46 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | High Blood Pressure |
| Dosage & duration: | | 40/12.5 (dosage frequency: once a day) for the period of 3 years |
| Other conditions: | | none |
| Other drugs taken: | | Potassium | | |
Reported Results |
| Benefits: | | The benefits were that it did help lower my blood pressure. |
| Side effects: | | With the HCT added to the Benicar, I was constantly going to the bathroom. My potassium got so low on this medication that I am currently taking 3 potassium pills daily. |
| Comments: | | Benicar/HCT was taken once a day due to my blood pressure being high. It did help control my blood pressure, if I ever forgot to take it I could feel the results - headache, etc. When I first began taking it I felt really tired all the time but eventually got used to it. I started losing weight (not because of the medication, I was actually trying to lose weight) and my potassium got so low that my physician took me off of the HCT part and started me just on the Benicar 40 mg daily. I am still taking potassium pills until my labs show that my potassium is okay. |
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| | Benicar HCT review by 46 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | High Blood Pressure |
| Dosage & duration: | | 40/12.5 (dosage frequency: once a day) for the period of 3 years |
| Other conditions: | | none |
| Other drugs taken: | | Potassium | | |
Reported Results |
| Benefits: | | The benefits were that it did help lower my blood pressure. |
| Side effects: | | With the HCT added to the Benicar, I was constantly going to the bathroom. My potassium got so low on this medication that I am currently taking 3 potassium pills daily. |
| Comments: | | Benicar/HCT was taken once a day due to my blood pressure being high. It did help control my blood pressure, if I ever forgot to take it I could feel the results - headache, etc. When I first began taking it I felt really tired all the time but eventually got used to it. I started losing weight (not because of the medication, I was actually trying to lose weight) and my potassium got so low that my physician took me off of the HCT part and started me just on the Benicar 40 mg daily. I am still taking potassium pills until my labs show that my potassium is okay. |
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Page last updated: 2009-10-31
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