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Benicar HCT (Olmesartan Medoxomil / Hydrochlorothiazide) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, BENICAR HCT® should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

BENICAR HCT SUMMARY

BENICAR HCT™ (olmesartan medoxomil-hydrochlorothiazide) is a combination of an angiotensin II receptor antagonist (AT1 subtype), olmesartan medoxomil, and a thiazide diuretic, hydrochlorothiazide (HCTZ).

BENICAR HCT™ is indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).


See all Benicar HCT indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

UF researchers use plants to study new ways of delivering drugs for pulmonary hypertension
Source: Endocrinology News From Medical News Today [2014.10.17]
UF researchers are using the leaves of plants to study new ways to deliver drugs that treat pulmonary hypertension, a disease with few treatment options, according to a study published online in...

Living closer to major roadways increases hypertension risk
Source: Hypertension News From Medical News Today [2014.10.03]
A new study in the Journal of the American Heart Association reports a significant association between living near a major roadway and the risk of high blood pressure.

Hypertension may be initiated by an autoimmune response
Source: Hypertension News From Medical News Today [2014.09.19]
High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease.

Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Source: Hypertension News From Medical News Today [2014.09.18]
The World Alzheimer Report 2014 'Dementia and Risk Reduction: An analysis of protective and modifiable factors', calls for dementia to be integrated into both global and national public health...

Men who improve their fitness levels can hold off development of hypertension
Source: Hypertension News From Medical News Today [2014.09.17]
A man's cardiorespiratory fitness can drastically delay the natural, age-associated increase of his blood pressure over his adult life span.

more news >>

Published Studies Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide in hypertensive patients with metabolic syndrome: the OLAS study. [2011.06]
We studied the effects of treatment with olmesartan/amlodipine and olmesartan/hydrochlorothiazide on inflammatory and metabolic parameters (including new-onset diabetes as a secondary endpoint) in non-diabetic hypertensive patients with metabolic syndrome (MetS)... Both olmesartan-based combinations were effective, but the amlodipine combination resulted in metabolic and anti-inflammatory effects that may have advantages over the hydrochlorothiazide combination.

Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients. [2008]
OBJECTIVE: To compare the effect of delapril/manidipine vs olmesartan/hydrochlorothiazide (HCTZ) combination on insulin sensitivity and plasma fibrinogen in obese hypertensive patients... CONCLUSION: In obese hypertensive patients the delapril/manidipine combination but not the olmesartan/HCTZ combination significantly decreased insulin resistance and plasma fibrinogen levels, despite the similar BP lowering efficacy.

Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide. [2004.03]
BACKGROUND: Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ)... CONCLUSIONS: Olmesartan medoxomil/HCTZ combination therapy produced BP reductions of up to 26.8/21.9 mm Hg and was well tolerated.

A review of olmesartan medoxomil monotherapy: antihypertensive efficacy similar to that of other angiotensin II receptor blocker/hydrochlorothiazide combinations? [2002.11]
Angiotensin II receptor blockers (ARBs) have been available in the United States since 1995...

Olmesartan medoxomil combined with hydrochlorothiazide improves 24-hour blood pressure control in moderate-to-severe hypertension. [2011.11.25]
Abstract Background: 24-hour ambulatory blood pressure monitoring has been shown to be more reliable than conventional measurements for hypertension assessment and the associated increased risk of cardiovascular events. Olmesartan/hydrochlorothiazide combination therapy has demonstrated increased blood pressure lowering over 24 hours compared with the component monotherapies...

more studies >>

Clinical Trials Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

Olmesartan in Essential Hypertension [Completed]
To test the efficacy and safety of olmesartan in patients with essential hypertension.

An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension [Completed]
Effect of increasing doses of olmesartan medoxomil and olmesartan medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension

Fed Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1 x 40 mg) dose administered under fed conditions.

Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's olmesartan medoxomil 40 mg tablets to Sankyo's Benicar® 40 mg tablets following a single, oral 40 mg (1 x 40 mg) dose administered under fasting conditions.

Parallel-Group Comparison of Olmesartan, Amlodipine and Hydrochlorothiazide in Hypertension [Recruiting]
This study is to determine the change in blood pressure from the administration of Olmesartan/Amlodipine/Hydrochlorothiazide triple combinations compared to dual combinations with Olmesartan/Amlodipine.

more trials >>

Reports of Suspected Benicar HCT (Olmesartan / Hydrochlorothiazide) Side Effects

Drug Ineffective (29)Blood Pressure Increased (15)Hypotension (14)Overdose (12)Weight Decreased (10)Oedema Peripheral (10)Blood Pressure Systolic Increased (9)Headache (8)Drug Administration Error (8)Dizziness (8)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Benicar HCT has an overall score of 7. The effectiveness score is 7.50 and the side effect score is 7.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Benicar HCT review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hypertension
Dosage & duration:   25mg taken 1x/day for the period of 2 years
Other conditions:   stress
Other drugs taken:   none
  
Reported Results
Benefits:   lowered blood presssure with no notable side effects.The reduction in blood pressure was immediate with no other bothersome side effects
Side effects:   none -- i was warned that many blood pressure medications have bothersome side-effects including lowered libido, sleep disturbances etc. i suffered no change in any physiological symptoms other than the lowering of my blood pressure
Comments:   Take the medication once per day and take measures to reduce the sources of stress in my life as well as take measures to more efficiently deal with existant daily stress.

 

Benicar HCT review by 55 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Hypertension
Dosage & duration:   20 mg/day taken once a day for the period of a couple of months
Other conditions:   Overweight but no other conditions
Other drugs taken:   none
  
Reported Results
Benefits:   Blood pressure was decreased initially to where it should have been, and gradually stopped being so effective
Side effects:   Severe rectal pain, beginning around 4 weeks into the treatment. At first there was burning, after bowel movements, then increased to severe burning all the time, then to pain, and finally severe pain (could not sit or lay down). No hemorrhoids, tears, or fisures, but the pain continued, even if no bowel movements for days. Finally stopped taking the medication at the end of August 2009, but the symptoms continue even now (Feb 2010), although not nearly as bad. Now the pain just makes me sit sideways, but at least I can sit and lay down to sleep.
Comments:   I had never been diagnosed with high blood pressure, but had recently gained several pounds because of the double round of steroids I was put on because of a severe skin rash (seasonal allergic reaction). Since we had recently moved I didn't have a PCP yet and the rash on my arms looked like it may have been getting infected, I went to a local emergent care center and saw a doctor there. They took my blood pressure and immediately put me on Benicar HCT, 20 mg, once a day. I took the medication as prescribed until the anal pain got to be too bad. Since going off the medication my BP is a little elevated but I'm reluctant to go back on any meds, especially no one seems to be willing to admit the Benicar caused this problem or is offering any solutions to help it get better.

 

Benicar HCT review by 55 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Hypertension
Dosage & duration:   20 mg/day taken once a day for the period of a couple of months
Other conditions:   Overweight but no other conditions
Other drugs taken:   none
  
Reported Results
Benefits:   Blood pressure was decreased initially to where it should have been, and gradually stopped being so effective
Side effects:   Severe rectal pain, beginning around 4 weeks into the treatment. At first there was burning, after bowel movements, then increased to severe burning all the time, then to pain, and finally severe pain (could not sit or lay down). No hemorrhoids, tears, or fisures, but the pain continued, even if no bowel movements for days. Finally stopped taking the medication at the end of August 2009, but the symptoms continue even now (Feb 2010), although not nearly as bad. Now the pain just makes me sit sideways, but at least I can sit and lay down to sleep.
Comments:   I had never been diagnosed with high blood pressure, but had recently gained several pounds because of the double round of steroids I was put on because of a severe skin rash (seasonal allergic reaction). Since we had recently moved I didn't have a PCP yet and the rash on my arms looked like it may have been getting infected, I went to a local emergent care center and saw a doctor there. They took my blood pressure and immediately put me on Benicar HCT, 20 mg, once a day. I took the medication as prescribed until the anal pain got to be too bad. Since going off the medication my BP is a little elevated but I'm reluctant to go back on any meds, especially no one seems to be willing to admit the Benicar caused this problem or is offering any solutions to help it get better.

See all Benicar HCT reviews / ratings >>

Page last updated: 2014-10-17

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