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Benadryl (Diphenhydramine Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The most frequent adverse reactions are underscored.

  1. General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose, and throat
  2. Cardiovascular System: Hypotension, headache, palpitations, tachycardia, extrasystoles
  3. Hematologic System: Hemolytic anemia, thrombocytopenia, agranulocytosis
  4. Nervous System: Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, neuritis, convulsions
  5. Gl System: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation
  6. GU System: Urinary frequency, difficult urination, urinary retention, early menses
  7. Respiratory System: Thickening of bronchial secretions, tightness of chest or throat and wheezing, nasal stuffiness


REPORTS OF SUSPECTED BENADRYL SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Benadryl. The information is not vetted and should not be considered as verified clinical evidence.

Possible Benadryl side effects / adverse reactions in 52 year old female

Reported by a consumer/non-health professional from United States on 2011-10-04

Patient: 52 year old female weighing 66.2 kg (145.7 pounds)

Reactions: Dyspnoea, Nausea, Hypotension, Somnolence, OFF Label USE, Drug Administration Error, Dizziness, Asthenia, Lethargy

Suspect drug(s):
Benadryl
    Dosage: 1 gel capsule at p.m.
    Administration route: Oral
    Indication: Pruritus
    End date: 2011-07-28

Benadryl
    Administration route: Oral

Benadryl
    Dosage: ^would rub the gel when did not take the capsule^.
    Administration route: Topical
    Indication: Pruritus

Other drugs received by patient: Coumadin



Possible Benadryl side effects / adverse reactions in 57 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-06

Patient: 57 year old female weighing 91.0 kg (200.2 pounds)

Reactions: Respiratory Arrest, Anaphylactic Shock

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Benadryl
    Indication: Premedication
    Start date: 2011-07-27
    End date: 2011-07-27

Gammagard Liquid
    Indication: Primary Immunodeficiency Syndrome
    Start date: 2011-07-27
    End date: 2011-07-27

Gammagard Liquid
    Start date: 2006-01-01

Other drugs received by patient: Wellbutrin; Quinine; Nasonex; Avelox; Prevacid; Synthroid; Docusate; Fenofibrate; Novogesic; Benadryl; Ramipril; Expectorant Syrup; Tiopronin; Aspirin; Novolin GE Toronto; APO-Methoprazine; APO-Salvent; Advair Diskus 100/50; Citalopram Hydrobromide; Tiazac; Novolin GE NPH; Metformin Hydrochloride; Domperidone; Senna; APO-Furosemide; Carbocal D; Clonazepam; Novolin GE NPH; Folic Acid; Novosemide; Tylenol-500



Possible Benadryl side effects / adverse reactions in 44 year old female

Reported by a individual with unspecified qualification from United States on 2011-10-07

Patient: 44 year old female weighing 80.3 kg (176.6 pounds)

Reactions: Pruritus, Pain in Extremity, Urinary Tract Infection, Pain, Somnolence, Joint Swelling, Arthralgia, Oedema Peripheral, Dysuria, Vertigo, Infusion Related Reaction

Suspect drug(s):
Xanax
    Dosage: 1 in 1 total, oral
    Administration route: Oral
    Start date: 2011-07-29
    End date: 2011-07-29

Valium
    Dosage: 1 in 1 total, oral
    Administration route: Oral
    Start date: 2011-07-29
    End date: 2011-07-29

Benlysta
    Dosage: 10 mg/kg, 1 in 28 d, intravenous drip
    Indication: Systemic Lupus Erythematosus
    Start date: 2011-07-29

Benadryl
    Dosage: 50 mg, 1 in 1 total, oral
    Administration route: Oral
    Start date: 2011-07-29
    End date: 2011-07-29

Other drugs received by patient: Tylenol PM (Tylenol PM) (Diphenhydramine, Paracetamol); Vicodin; Hydroxyzine; Dilaudid; Marijuana (Cannabis Sativa); Calcium Plus Vitamin D (Vitacal) (Calcium, Vitamin D Nos); Prednisone TAB; Klonopin; Super B Complex Vitamin (Becosym Forte) (Pyridoxine Hydrochloride, THI; Omeprazole; Venlfaxine; Remeron; Mobic; Mysoline



See index of all Benadryl side effect reports >>

Drug label data at the top of this Page last updated: 2006-05-11

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