BAL IN OIL SUMMARY
BAL in Oil Ampules
DIMERCAPROL INJECTION, USP
Dimercaprol Injection USP is a colorless or almost colorless liquid chelating agent having a disagreeable, mercaptan-like odor. Each 1 mL sterile BAL in Oil (Dimercaprol Injection USP) contains: 100 mg Dimercaprol in 200 mg Benzyl Benzoate and 700 mg Peanut Oil.
BAL in Oil (Dimercaprol Injection USP) is indicated in the treatment of arsenic, gold and mercury poisoning. It is indicated in acute lead poisoning when used concomitantly with Edetate Calcium Disodium Injection USP.
Dimercaprol Injection USP is effective for use in acute poisoning by mercury salts if therapy is begun within one or two hours following ingestion. It is not very effective for chronic mercury poisoning.
Dimercaprol Injection USP is of questionable value in poisoning caused by other heavy metals such as antimony and bismuth. It should not be used in iron, cadmium, or selenium poisoning because the resulting dimercaprol-metal complexes are more toxic than the metal alone, especially to the kidneys.
|
NEWS HIGHLIGHTSMedia Articles Related to BAL in Oil (Dimercaprol)
Yale Researchers Succeed In Repairing Brain Damage Caused By Chronic Stress, Lead Poisoning, Potential Implications For Bipolar Disorder
Source: Bipolar News From Medical News Today [2009.09.10]
Yale University researchers report in the Proceedings of the National Academy of Sciences (September 7-11 edition) that damage to the brain caused by chronic stress or lead poisoning can be repaired by blocking a key molecular pathway. Research shows that rats exposed to chronic stress develop damage to the prefrontal cortex. This is an area of the brain essential to working memory, impulse control and the ability to stay focused on tasks.
Chelation Therapy Drug Found Safe And Beneficial For Children With Autism
Source: Autism News From Medical News Today [2009.11.06]
Two studies published by the Southwest College of Naturopathic Medicine in the October issue of BMC Clinical Pharmacology investigated the use of oral dimercaptosuccinic acid (DMSA), a prescription medicine approved by the FDA for treating lead poisoning, and used off-label in these studies for treating heavy metal toxicity in children with autism. In the investigations, DMSA was given to 65 children with autism (ages 3 -8 years) to determine its effects.
Yale Researchers Repair Brain Damage Caused By Chronic Stress Work Has Implications For Bipolar Disorder, PTSD
Source: Bipolar News From Medical News Today [2009.09.09]
Damage to the brain caused by chronic stress or lead poisoning can be repaired by blocking a key molecular pathway, Yale University researchers report in the September 7-11 edition of the Proceedings of the National Academy of Sciences. Rats subjected to chronic stress develop damage to the prefrontal cortex, an area of the brain crucial to working memory, impulse control and the ability to stay focused on tasks.
Published Studies Related to BAL in Oil (Dimercaprol)
Bismuth dimercaptopropanol (BisBAL) inhibits the expression of extracellular polysaccharides and proteins by Brevundimonas diminuta: implications for membrane microfiltration. [2008.02.15]
A 2:1 molar ratio preparation of bismuth with a lipophilic dithiol (3-dimercapto-1-propanol, BAL) significantly reduced extracellular polymeric substances (EPS) expression by Brevundimonas diminuta in suspended cultures at levels just below the minimum inhibitory concentration (MIC).diminuta resulted in biofouling and inefficient hydrodynamic backwashing of microfiltration membranes.
Inhibition of bacterial adherence on the surface of stents and bacterial growth in bile by bismuth dimercaprol. [2005.06]
Bacterial infection and biofilm formation on the surface of biliary stents is believed to be one of the main factors in stent occlusion. This study explored the role of the new reagent, bismuth dimercaprol, in preventing bacterial adherence and bacterial biofilm formation on the surface of biliary stents...
Toxicity induced by Hg2+ on choline acetyltransferase activity from E. electricus (L.) electrocytes: the protective effect of 2,3 dimercapto-propanol (BAL). [2005.04]
CONCLUSIONS: The observed inhibition is likely due to direct protein interaction, because the addition of BAL reversed the effects of HgCl(2) on ChAT activity. The results cast new light on the mechanisms of mercurial neurotoxicity.
British anti-Lewisite (dimercaprol): an amazing history. [2003.03]
Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic... Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces.
Denny-Brown, Wilson's disease, and BAL (British antilewisite [2,3-dimercaptopropanol]). [2002.09.24]
In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder.
|
|
|
|
Page last updated: 2009-11-06
|
