(mupirocin calcium cream) 2%
For Dermatologic Use
Bactroban Cream (mupirocin calcium cream), 2% contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin.
Bactroban Cream (mupirocin calcium cream), 2% is indicated for the treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm2 in area) due to susceptible strains of
Published Studies Related to Bactroban (Mupirocin Topical)
A randomized trial of mupirocin sinonasal rinses versus saline in surgically
recalcitrant staphylococcal chronic rhinosinusitis. 
STUDY DESIGN: Prospective, double-blinded, placebo-controlled study... CONCLUSIONS: Mupirocin sinonasal rinses are an effective short-term anti-S aureus
A Randomized Controlled Trial Comparing Mupirocin and Polysporin Triple Ointments in Peritoneal Dialysis Patients: The MP3 Study. [2011.12.01]
Background and objectivesInfectious complications remain a significant cause of peritoneal dialysis (PD) technique failure. Topical ointments seem to reduce peritonitis; however, concerns over resistance have led to a quest for alternative agents...
The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals. [2010.12]
BACKGROUND: HIV-positive patients at HELP/PSI, Inc, an in-patient drug rehabilitation center, had a high baseline prevalence of Staphylococcus aureus colonization (49%) and incidence of infection (17%) in a previous year-long study... CONCLUSIONS: Monthly application of nasal mupirocin significantly decreased S. aureus colonization in HIV patients in residential drug rehabilitation. Monthly mupirocin application has a potential role in long-term care settings or in HIV-positive patients with high rates of S. aureus colonization and infection.
The NOSE Study (Nasal Ointment for Staphylococcus aureus Eradication): A Randomized Controlled Trial of Monthly Mupirocin in HIV-Infected Individuals. [2010.08.03]
BACKGROUND:: HIV-positive patients at HELP/PSI, Inc, an in-patient drug rehabilitation center, had a high baseline prevalence of Staphylococcus aureus colonization (49%) and incidence of infection (17%) in a previous year-long study... CONCLUSIONS:: Monthly application of nasal mupirocin significantly decreased S. aureus colonization in HIV patients in residential drug rehabilitation. Monthly mupirocin application has a potential role in long-term care settings or in HIV-positive patients with high rates of S. aureus colonization and infection.
A double-blind, randomized, controlled trial of topical polysporin triple compound versus topical mupirocin for the eradication of colonization with methicillin-resistant Staphylococcus aureus in a complex continuing care population. [2009.09]
BACKGROUND: Intranasal mupirocin or Polysporin Triple (PT) ointment (polymyxin B, bacitracin, gramicidin), in combination with chlorhexidine body washes, have been used for eradicating methicillin-resistant Staphylococcus aureus (MRSA), but no comparative studies have been done... CONCLUSION: Both agents demonstrated poor efficacy and PT was significantly less efficacious than mupirocin at 12 weeks in eradicating MRSA from all sites.
Clinical Trials Related to Bactroban (Mupirocin Topical)
Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin [Recruiting]
We hypothesize the application of mupirocin or povidone-iodine to the nares is equally
effective in short term Staphylococcus aureus(SA)suppression. Our overall study objective
is to measure the rate of deep and superficial Surgical Site Infections (SSIs) after primary
hip, knee, shoulder and elbow arthroplasty surgery and primary spinal fusion surgery
requiring implantation of prosthetic material, when the patient receives either nasal
mupirocin or nasal povidone-iodine prior to surgery.
Secondary study objectives include:
1. Measure hospital length of stay and re-admission rates in the mupirocin and
2. Measure adverse events related to mupirocin and povidone-iodine.
3. Measure rate of SA resistance to mupirocin.
Nasal Application of 5% Tea Tree Oil (TTO) Versus Mupirocin for the Prevention of Catheter-associated Infections in Renal Dialysis Patients [Recruiting]
This study will compare the use of tea tree oil against mupirocin as a topical nasal
antiseptic to see which is best at preventing infections in patients that need renal
dialysis. Fifty subjects will be recruited into each arm of the trial and will be assessed
for signs of infection once per week for the first 6 weeks and then every 4 weeks until week
26. They will also be checked for nasal carriage of 'Golden Staph' when they enroll in the
trial. The subjects will complete the trial if they have 26 weeks infection-free or if they
have an infection during that period
Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis [Not yet recruiting]
Catheter-related infection, namely exit site infection and peritonitis, is the commonest
complication of peritoneal dialysis. This complication causes significant morbidity and
mortality in patients requiring peritoneal dialysis. Topical application of mupirocin 2%
cream was first proven to be effective in reduction of staphylococcus-related catheter
infection in 1990s. Subsequent randomized trial published in 2005 showed that gentamicin
cream was superior to mupirocin 2% cream in reducing both Gram's positive and Gram's
negative related catheter infection. However, a retrospective report published in 2007 puts
the use of prophylactic antibiotic cream into a question. It reported an emergency of
non-tuberculous mycobacterial infection in a dialysis center in Hong Kong after practising
prophylactic application of gentamicin cream at the catheter exit site. The following
prospective, randomized and open-label study aims to find out an optimal regimen of topical
antibiotic prophylaxis in patients requiring peritoneal dialysis.
Prophylaxis With Intranasal Mupirocin for Prevention of S. Aureus Infections [Completed]
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on
subsequent Staphylococcus aureus infection, a prospective randomized trial was performed
particularly including patients with predisposing risk factors for S. aureus infections.
Randomized Controlled Trial of Standard Versus Systemic Decolonization Therapy for the Eradication of Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization [Recruiting]
MRSA decolonization may reduce the risk of subsequent MRSA infection and further
transmission. A recent randomized controlled trial demonstrated that systemic decolonization
may be safe and effective among hospitalized patients when compared to no treatment. As a
large number of the investigators patients require re-admission and further transmission may
take place in the community, the investigators are comparing the standard decolonization
protocol for MRSA eradication to the systemic decolonization protocol among an ambulatory
Standard decolonization protocols, which use only topical agents, are limited in efficacy.
The method of systemic decolonization to be studied here appears to have greater efficacy
than the standard approach using only topical agents. However, concerns have been raised
that the increased use of systemic antibiotics may lead to increased levels of drug
resistance adverse effects, without sustained decolonization. This study seeks to provide
further data to help answer these questions and provide guidance for further policy
development and implementation.
Reports of Suspected Bactroban (Mupirocin Topical) Side Effects
Drug Ineffective (14),
Condition Aggravated (12),
Rash Pruritic (11),
Blood Cholesterol Increased (10),
Rash Pustular (10),
Rash Papular (10), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Bactroban has an overall score of 6. The effectiveness score is 4 and the side effect score is 2. The scores are on ten point scale: 10 - best, 1 - worst.
Bactroban review by 52 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Marginally Effective|
|Side effects:|| || Extremely Severe Side Effects|
|Condition / reason:|| || amputee, constant sores on stump|
|Dosage & duration:|| || antibiotic creams as needed (dosage frequency: all most all the time) for the period of since seventeen when I lost my leg|
|Other conditions:|| || infections|
|Other drugs taken:|| || siezure meds|
|Benefits:|| || to eliminate sores on stump and siezures|
|Side effects:|| || tried everything to know avail.|
|Comments:|| || I put some of Mary Kay night solution on my stump on it and low and behold it was almost cleared up over night. Would love to tell you more about it. Reach me at my e-mail address: email@example.com or my home phone 218-346-6987. My daughter started selling Mary Kay, Thank you sincerely, Coleen Sundberg, Perham, MN 56573|
Page last updated: 2013-02-10